Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Christopher J, Zerio"'
Autor:
Liberty François-Moutal, David Donald Scott, Andrew J. Ambrose, Christopher J. Zerio, Marina Rodriguez-Sanchez, Kumara Dissanayake, Danielle G. May, Jacob M. Carlson, Edward Barbieri, Aubin Moutal, Kyle J. Roux, James Shorter, Rajesh Khanna, Sami J. Barmada, Leeanne McGurk, May Khanna
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no cure or effective treatment in which TAR DNA Binding Protein of 43 kDa (TDP-43) abnormally accumulates into misfolded protein aggregates in affected neurons. It
Externí odkaz:
https://doaj.org/article/15ebfd3809d6429cb150916d1d91bb88
Autor:
Derek J. Essegian, Tyler A. Cunningham, Christopher J. Zerio, Eli Chapman, Jonathan Schatz, Stephan C. Schürer
Publikováno v:
ACS Omega, Vol 6, Iss 38, Pp 24432-24443 (2021)
Externí odkaz:
https://doaj.org/article/7980bb329b004d37b04673cf8626bb3d
Autor:
Jared Sivinski, Andrew J. Ambrose, Iliya Panfilenko, Christopher J. Zerio, Jason M. Machulis, Niloufar Mollasalehi, Lynn K. Kaneko, Mckayla Stevens, Anne-Marie Ray, Yangshin Park, Chunxiang Wu, Quyen Q. Hoang, Steven M. Johnson, Eli Chapman
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
The GroES/GroEL chaperonin from E. coli
Externí odkaz:
https://doaj.org/article/ebd31eb709974744bdcf006fa3005b0d
Autor:
Jonathan H. Schatz, Eli Chapman, Abimael D. Rodríguez, Graham Packham, Cyril H. Benes, Francisco Vega, Patricia Greninger, Gillian Paine-Murrieta, Andrew J. Ambrose, Christopher J. Zerio, Praechompoo Pongtornpipat, Amit D. Amin, Lingxiao Li, Luis A. Amador, Carlos Jiménez-Romero, Elizabeth Lemm, Sarah Wilmore, Alison M. Yeomans, Joseph Tillotson, Tara L. Peters
Figure S1. Elatol was submitted to a 96-member kinome screen to evaluate specificity. Figure S2. A) Michaelis-Menten curves of eIF4A1 wild type (blue), K82R (red), and K238E (green). Michaelis- Menten constants for eIF4A1 wild type and mutants in tab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b0c08aa1ad75e37b8b895a22244a71
https://doi.org/10.1158/1078-0432.22469778.v1
https://doi.org/10.1158/1078-0432.22469778.v1
Autor:
Jonathan H. Schatz, Eli Chapman, Abimael D. Rodríguez, Graham Packham, Cyril H. Benes, Francisco Vega, Patricia Greninger, Gillian Paine-Murrieta, Andrew J. Ambrose, Christopher J. Zerio, Praechompoo Pongtornpipat, Amit D. Amin, Lingxiao Li, Luis A. Amador, Carlos Jiménez-Romero, Elizabeth Lemm, Sarah Wilmore, Alison M. Yeomans, Joseph Tillotson, Tara L. Peters
Purpose: The DEAD-box RNA helicase eIF4A1 carries out the key enzymatic step of cap-dependent translation initiation and is a well-established target for cancer therapy, but no drug against it has entered evaluation in patients. We identified and cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0a4100a7388fdcb4d088138f676666
https://doi.org/10.1158/1078-0432.c.6527340
https://doi.org/10.1158/1078-0432.c.6527340
Autor:
Christopher J. Zerio, Jared Sivinski, E. M. Kithsiri Wijeratne, Ya-Ming Xu, Duc T. Ngo, Andrew J. Ambrose, Luis Villa-Celis, Niloofar Ghadirian, Michael W. Clarkson, Donna D. Zhang, Nancy C. Horton, A. A. Leslie Gunatilaka, Raimund Fromme, Eli Chapman
Publikováno v:
Journal of medicinal chemistry.
A pulldown using a biotinylated natural product of interest in the 17β-hydroxywithanolide (17-BHW) class, physachenolide C (PCC), identified the bromodomain and extra-terminal domain (BET) family of proteins (BRD2, BRD3, and BRD4), readers of acetyl
Autor:
Andrew J. Ambrose, Jared Sivinski, Christopher J. Zerio, Xiaoyi Zhu, Jack Godek, Vlad K. Kumirov, Teresa Coma Brujas, Joan Torra Garcia, Anandhan Annadurai, Cody J. Schmidlin, Alyssa Werner, Taoda Shi, Reza Beheshti Zavareh, Luke Lairson, Donna D. Zhang, Eli Chapman
Publikováno v:
Journal of medicinal chemistry.
A recent study illustrated that a fluorescence polarization assay can be used to identify substrate-competitive Hsp70 inhibitors that can be isoform-selective. Herein, we use that assay in a moderate-throughput screen and report the discovery of a dr
Autor:
Jonathan H. Schatz, Derek J. Essegian, Tyler A. Cunningham, Christopher J. Zerio, Stephan C. Schürer, Eli Chapman
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 38, Pp 24432-24443 (2021)
ACS Omega, Vol 6, Iss 38, Pp 24432-24443 (2021)
eIF4A1 is an ATP-dependent RNA helicase whose overexpression and activity have been tightly linked to oncogenesis in a number of malignancies. An understanding of the complex kinetics and conformational changes of this translational enzyme is necessa
Autor:
Jared Sivinski, Duc Ngo, Christopher J. Zerio, Andrew J. Ambrose, Edmond R. Watson, Lynn K. Kaneko, Marius M. Kostelic, Mckayla Stevens, Anne‐Marie Ray, Yangshin Park, Chunxiang Wu, Michael T. Marty, Quyen Q. Hoang, Donna D. Zhang, Gabriel C. Lander, Steven M. Johnson, Eli Chapman
Publikováno v:
FASEB J
GroES/GroEL is the only bacterial chaperone essential under all conditions, making it a potential antibiotic target. Rationally targeting ESKAPE GroES/GroEL as an antibiotic strategy necessitates studying their structure and function. Herein, we outl
Autor:
Liberty François-Moutal, David Donald Scott, Andrew J. Ambrose, Christopher J. Zerio, Marina Rodriguez-Sanchez, Kumara Dissanayake, Danielle G. May, Jacob M. Carlson, Edward Barbieri, Aubin Moutal, Kyle J. Roux, James Shorter, Rajesh Khanna, Sami J. Barmada, Leeanne McGurk, May Khanna
Publikováno v:
Scientific reports. 12(1)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no cure or effective treatment in which TAR DNA Binding Protein of 43 kDa (TDP-43) abnormally accumulates into misfolded protein aggregates in affected neurons. It is widel