Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Christopher J, Tonkin"'
Autor:
Tamara L. Baker, David K. Wright, Alessandro D. Uboldi, Christopher J. Tonkin, Anh Vo, Trevor Wilson, Stuart J. McDonald, Richelle Mychasiuk, Bridgette D. Semple, Mujun Sun, Sandy R. Shultz
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-31 (2024)
Abstract Traumatic brain injury (TBI) is a key contributor to global morbidity that lacks effective treatments. Microbial infections are common in TBI patients, and their presence could modify the physiological response to TBI. It is estimated that o
Externí odkaz:
https://doaj.org/article/dd19e4fc213b4406a1fdbe90f4f928eb
Autor:
Madeline G Dans, Henni Piirainen, William Nguyen, Sachin Khurana, Somya Mehra, Zahra Razook, Niall D Geoghegan, Aurelie T Dawson, Sujaan Das, Molly Parkyn Schneider, Thorey K Jonsdottir, Mikha Gabriela, Maria R Gancheva, Christopher J Tonkin, Vanessa Mollard, Christopher Dean Goodman, Geoffrey I McFadden, Danny W Wilson, Kelly L Rogers, Alyssa E Barry, Brendan S Crabb, Tania F de Koning-Ward, Brad E Sleebs, Inari Kursula, Paul R Gilson
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3002066 (2023)
With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red blood cell (RBC) invasion, and
Externí odkaz:
https://doaj.org/article/d4ae40a3c3394669ac6efd4a149b5ec0
Autor:
Tamara L. Baker, Alessandro D. Uboldi, Christopher J. Tonkin, David K. Wright, Anh Vo, Trevor Wilson, Richelle Mychasiuk, Stuart J. McDonald, Bridgette D. Semple, Mujun Sun, Sandy R. Shultz
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2023)
IntroductionPost-traumatic epilepsy (PTE) is a debilitating chronic outcome of traumatic brain injury (TBI), and neuroinflammation is implicated in increased seizure susceptibility and epileptogenesis. However, how common clinical factors, such as in
Externí odkaz:
https://doaj.org/article/4592529e97cd40d78e368d66a3902479
Publikováno v:
PLoS Biology, Vol 20, Iss 5, p e3001638 (2022)
Cryptosporidium is a leading cause of death from childhood diarrhea, but its biology is poorly understood. A recent study in PLOS Biology reveals hitherto unknown aspects of the parasite's life cycle that may lead to improvements in ex vivo culture.
Externí odkaz:
https://doaj.org/article/9d986d7e399b48999d07565816c1089f
Autor:
Tamara L. Baker, Mujun Sun, Bridgette D. Semple, Shiraz Tyebji, Christopher J. Tonkin, Richelle Mychasiuk, Sandy R. Shultz
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-19 (2020)
Abstract Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality worldwide; however, treatment development is hindered by the heterogenous nature of TBI presentation and pathophysiology. In particular, the degree of neuro
Externí odkaz:
https://doaj.org/article/f8e8f34c58dd4a44bc9eaeddbae91438
Autor:
V. Vern Lee, Louise M. Judd, Aaron R. Jex, Kathryn E. Holt, Christopher J. Tonkin, Stuart A. Ralph
Publikováno v:
mSystems, Vol 6, Iss 2 (2021)
ABSTRACT Alternative splicing is a widespread phenomenon in metazoans by which single genes are able to produce multiple isoforms of the gene product. However, this has been poorly characterized in apicomplexans, a major phylum of some of the most im
Externí odkaz:
https://doaj.org/article/5e6e2bd160d641ada2a753d8ee4b707c
Publikováno v:
Cell Reports, Vol 31, Iss 4, Pp - (2020)
Summary: Germline epigenetic factors influence transgenerational inheritance of behavioral traits upon changes in experience and environment. Immune activation due to infection can also modulate brain function, but whether this experience can be pass
Externí odkaz:
https://doaj.org/article/1b9b32f3fb3b4f9e9e7a4bed4df0308b
Autor:
Mary-Louise Wilde, Tony Triglia, Danushka Marapana, Jennifer K. Thompson, Alexei A. Kouzmitchev, Hayley E. Bullen, Paul R. Gilson, Alan F. Cowman, Christopher J. Tonkin
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Understanding the mechanisms behind host cell invasion by Plasmodium falciparum remains a major hurdle to developing antimalarial therapeutics that target the asexual cycle and the symptomatic stage of malaria. Host cell entry is enabled by
Externí odkaz:
https://doaj.org/article/e57a13863f35463ca89cb2fe9e8b1b58
Autor:
Michael J. Coffey, Laura F. Dagley, Simona Seizova, Eugene A. Kapp, Giuseppe Infusini, David S. Roos, Justin A. Boddey, Andrew I. Webb, Christopher J. Tonkin
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Toxoplasma gondii infects approximately 30% of the world’s population, causing disease primarily during pregnancy and in individuals with weakened immune systems. Toxoplasma secretes and exports effector proteins that modulate the host dur
Externí odkaz:
https://doaj.org/article/ea7a3291199047328178731b63d09cfa
Autor:
Alessandro D Uboldi, Mary-Louise Wilde, Emi A McRae, Rebecca J Stewart, Laura F Dagley, Luning Yang, Nicholas J Katris, Sanduni V Hapuarachchi, Michael J Coffey, Adele M Lehane, Cyrille Y Botte, Ross F Waller, Andrew I Webb, Malcolm J McConville, Christopher J Tonkin
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2005642 (2018)
The phylum Apicomplexa comprises a group of obligate intracellular parasites that alternate between intracellular replicating stages and actively motile extracellular forms that move through tissue. Parasite cytosolic Ca2+ signalling activates motili
Externí odkaz:
https://doaj.org/article/b74ca0993f11485cab44baf31f1908a9