Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Christopher J, Squire"'
Autor:
Ghader Bashiri, Esther M. M. Bulloch, William R. Bramley, Madison Davidson, Stephanie M. Stuteley, Paul G. Young, Paul W. R. Harris, Muhammad S. H. Naqvi, Martin J. Middleditch, Michael Schmitz, Wei-Chen Chang, Edward N. Baker, Christopher J. Squire
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Poly-γ-glutamate tails are a distinctive feature of archaeal, bacterial, and eukaryotic cofactors, including the folates and F420. Despite decades of research, key mechanistic questions remain as to how enzymes successively add glutamates t
Externí odkaz:
https://doaj.org/article/4c044e76cc0a465894eb45f0998959cb
Autor:
Runzhong Wang, Bicheng Zhu, Paul Young, Yu Luo, John Taylor, Alan J. Cameron, Christopher J. Squire, Jadranka Travas-Sejdic
Publikováno v:
Biosensors, Vol 14, Iss 1, p 10 (2023)
The COVID-19 pandemic caused by the virus SARS-CoV-2 was the greatest global threat to human health in the last three years. The most widely used methodologies for the diagnosis of COVID-19 are quantitative reverse transcription polymerase chain reac
Externí odkaz:
https://doaj.org/article/ab62e63580604975af75434e33c239d2
Autor:
David P. Kelly, Melanie Spotheim-Maurizot, Denise Sy, Chris Clark, Jonathan M. White, Pavel N. Lobachevsky, George R. Clark, Christopher J. Squire, Monica E. Reum, Sam Broadhurst, Roger F. Martin
12 pages of supplementary material (Materials and Methods, 3 tables, 3 figures, references)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c41de755fa09d10e49491e3658d37c3
https://doi.org/10.1158/0008-5472.22363523
https://doi.org/10.1158/0008-5472.22363523
Autor:
David P. Kelly, Melanie Spotheim-Maurizot, Denise Sy, Chris Clark, Jonathan M. White, Pavel N. Lobachevsky, George R. Clark, Christopher J. Squire, Monica E. Reum, Sam Broadhurst, Roger F. Martin
New analogues of the minor groove binding ligand Hoechst 33342 have been investigated in an attempt to improve radioprotective activity. The synthesis, DNA binding, and in vitro radioprotective properties of methylproamine, the most potent derivative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a751037758badc16f0de0f758d41369f
https://doi.org/10.1158/0008-5472.c.6493754.v1
https://doi.org/10.1158/0008-5472.c.6493754.v1
Publikováno v:
Viruses, Vol 7, Iss 2, Pp 709-738 (2015)
Multiple repeats of the ankyrin motif (ANK) are ubiquitous throughout the kingdoms of life but are absent from most viruses. The main exception to this is the poxvirus family, and specifically the chordopoxviruses, with ANK repeat proteins present in
Externí odkaz:
https://doaj.org/article/0bf7c01c630c43208adffabb849823bd
Autor:
Jinal Patel, Ries J. Langley, Petr Tomek, Bruce C. Baguley, David Barker, Euphemia Leung, Ayesha Zafar, Christopher J. Squire, Michelle van Rensburg, Lisa I. Pilkington, Jennifer A. Hollywood, Ivanhoe K. H. Leung, Nuala A. Helsby, William A. Denny, Jóhannes Reynisson
Publikováno v:
Oncology and Therapy
Cancer chemotherapy sensitizers hold the key to maximizing the potential of standard anticancer treatments. We have a long-standing interest in developing and validating inhibitors of the DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (TDP1) as ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395b729365257e39d418a57e44e4a605
https://doi.org/10.1007/s40487-021-00158-0
https://doi.org/10.1007/s40487-021-00158-0
Autor:
Xiaojing Lin, Yuliana Yosaatmadja, Maria Kalyukina, Martin J. Middleditch, Zhen Zhang, Xiaoyun Lu, Ke Ding, Adam V. Patterson, Jeff B. Smaill, Christopher J. Squire
Publikováno v:
ACS Med Chem Lett
[Image: see text] Aberration in FGFR4 signaling drives carcinogenesis and progression in a subset of hepatocellular carcinoma (HCC) patients, thereby making FGFR4 an attractive molecular target for this disease. Selective FGFR4 inhibition can be achi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200419c850590b39124ba936fda0d528
https://doi.org/10.1021/acsmedchemlett.9b00196
https://doi.org/10.1021/acsmedchemlett.9b00196
Autor:
Ikumi Tamai, Khine Myint, Yan Li, Fabrice Merien, Catherine H. Han, Johnson J. Liu, Mark J. McKeage, Stephen M. F. Jamieson, Takeo Nakanishi, Jun Lu, Nancy N. Jong, Christopher J. Squire, Riya Biswas
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Oxaliplatin is important for the clinical treatment of colorectal cancer and other gastrointestinal malignancies, but tumour resistance is limiting. Several oxaliplatin transporters were previously identified but their relative contributions to deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d84c43d65a152e4d364df7d5c85cce8
http://link.springer.com/article/10.1038/s41598-019-38667-8
http://link.springer.com/article/10.1038/s41598-019-38667-8
Autor:
James L. O. McKellar, Maria Selmer, Christopher J. Squire, Wayne M. Patrick, Jodi L. Brewster, Petr Pachl
Publikováno v:
The Journal of Biological Chemistry
Bacterial methionine biosynthesis can take place by either the trans-sulfurylation route or direct sulfurylation. The enzymes responsible for trans-sulfurylation have been characterized extensively because they occur in model organisms such as Escher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38809c5ec91093d9cd094421246ac864
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-452305
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-452305
Autor:
Jack U Flanagan, Yuliana Yosaatmadja, Rebecca M Teague, Matilda Z L Chai, Andrew P Turnbull, Christopher J Squire
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43965 (2012)
Aldo-keto reductase 1C3 (AKR1C3) catalyses the NADPH dependent reduction of carbonyl groups in a number of important steroid and prostanoid molecules. The enzyme is also over-expressed in prostate and breast cancer and its expression is correlated wi
Externí odkaz:
https://doaj.org/article/7b40b3a682af4842b8a1418c97a7a97c