Zobrazeno 1 - 10
of 534
pro vyhledávání: '"Christopher J, Rhodes"'
Autor:
Klaudia Jomova, Marcel Cvik, Terezia Orolinova, Suliman Y. Alomar, Saleh H. Alwasel, Waleed Aldahmash, Safa Alqarzae, Ali Al-Juaimlani, Eugenie Nepovimova, Kamil Kuca, Christopher J. Rhodes, Marian Valko
Publikováno v:
Journal of Agriculture and Food Research, Vol 16, Iss , Pp 101112- (2024)
Flavonoids are natural antioxidants, found in vegetables, fruits, flowers, coffee, tea, wine, and other foodstuffs. They are well known for their health benefits, and various clinical trials have determined that a sufficient intake of flavonoids is r
Externí odkaz:
https://doaj.org/article/1e391a9bd37845ce8e33c5f18eaeb41d
Autor:
Anna Ulrich, Yukyee Wu, Harmen Draisma, John Wharton, Emilia M. Swietlik, Inês Cebola, Eleni Vasilaki, Zhanna Balkhiyarova, Marjo-Riitta Jarvelin, Juha Auvinen, Karl-Heinz Herzig, J. Gerry Coghlan, James Lordan, Colin Church, Luke S. Howard, Joanna Pepke-Zaba, Mark Toshner, Stephen J. Wort, David G. Kiely, Robin Condliffe, Allan Lawrie, Stefan Gräf, Nicholas W. Morrell, Martin R. Wilkins, Inga Prokopenko, Christopher J. Rhodes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Pulmonary arterial hypertension (PAH) is characterised by pulmonary vascular remodelling causing premature death from right heart failure. Established DNA variants influence PAH risk, but susceptibility from epigenetic changes is unknown. We
Externí odkaz:
https://doaj.org/article/8e50277bf2c448aa930fb3478374f053
Autor:
Alexander J. Ainscough, Timothy J. Smith, Maike Haensel, Christopher J. Rhodes, Adam Fellows, Harry J. Whitwell, Eleni Vasilaki, Kelly Gray, Adrian Freeman, Luke S. Howard, John Wharton, Benjamin Dunmore, Paul D. Upton, Martin R. Wilkins, Joshua B. Edel, Beata Wojciak-Stothard
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
A biomimetic inducible model of pulmonary arterial hypertension (PAH) is presented, combining natural and induced BMPR2 dysfunction with hypoxia in lung endothelial cells and blood-derived PAH cells to induce smooth muscle activation & proliferation.
Externí odkaz:
https://doaj.org/article/23b65781f0864f158a058def624a88d9
Autor:
Jaco Selle, Katharina Dinger, Vanessa Jentgen, Daniela Zanetti, Johannes Will, Theodoros Georgomanolis, Christina Vohlen, Rebecca Wilke, Baktybek Kojonazarov, Oleksiy Klymenko, Jasmine Mohr, Silke v. Koningsbruggen-Rietschel, Christopher J. Rhodes, Anna Ulrich, Dharmesh Hirani, Tim Nestler, Margarete Odenthal, Esther Mahabir, Sreenath Nayakanti, Swati Dabral, Thomas Wunderlich, James Priest, Werner Seeger, Jörg Dötsch, Soni S. Pullamsetti, Miguel A. Alejandre Alcazar
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
This study shows that maternal and perinatal obesity cause bronchial and vascular smooth muscle cell proliferation through an IL-6-FoxO1 axis, and favor thereby the emergence of bronchial obstruction and pulmonary hypertension later in life.
Externí odkaz:
https://doaj.org/article/b4419ac41c554af68c918ae4ee7c5d81
Autor:
Sara E. Stinson, Anna E. Jonsson, Mette K. Andersen, Morten A. V. Lund, Louise Aas Holm, Cilius E. Fonvig, Yun Huang, Evelina Stankevič, Helene Bæk Juel, Lars Ängquist, Thorkild I. A. Sørensen, Emily L. Ongstad, Ranjitha Gaddipati, Joseph Grimsby, Christopher J. Rhodes, Oluf Pedersen, Michael Christiansen, Jens‐Christian Holm, Torben Hansen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 3 (2023)
Background Lectin‐like oxidized low‐density lipoprotein (ox‐LDL) receptor‐1 is a scavenger receptor for oxidized low‐density lipoprotein. In adults, higher soluble lectin‐like ox‐LDL receptor‐1 (sLOX‐1) levels are associated with ca
Externí odkaz:
https://doaj.org/article/f8e2b7bde0c84cd1a9abf38ec9a67ea9
Autor:
Sokratis Kariotis, Emmanuel Jammeh, Emilia M. Swietlik, Josephine A. Pickworth, Christopher J. Rhodes, Pablo Otero, John Wharton, James Iremonger, Mark J. Dunning, Divya Pandya, Thomas S. Mascarenhas, Niamh Errington, A. A. Roger Thompson, Casey E. Romanoski, Franz Rischard, Joe G. N. Garcia, Jason X.-J. Yuan, Tae-Hwi Schwantes An, Ankit A. Desai, Gerry Coghlan, Jim Lordan, Paul A. Corris, Luke S. Howard, Robin Condliffe, David G. Kiely, Colin Church, Joanna Pepke-Zaba, Mark Toshner, Stephen Wort, Stefan Gräf, Nicholas W. Morrell, Martin R. Wilkins, Allan Lawrie, Dennis Wang, UK National PAH Cohort Study Consortium
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Idiopathic pulmonary arterial hypertension is a rare and fatal disease with a heterogeneous treatment response. Here the authors show that unsupervised machine learning of whole blood transcriptomes from 359 patients with idiopathic pulmonary arteria
Externí odkaz:
https://doaj.org/article/f8e37550b75b47d2a53cbd19d4302aa9
Autor:
Wenwen Cheng, Ermelinda Ndoka, Jessica N. Maung, Warren Pan, Alan C. Rupp, Christopher J. Rhodes, David P. Olson, Martin G. Myers
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Calcitonin receptor-expressing neurons of the nucleus tractus solitarius contribute to long-term control of food intake and body weight. The authors show that a subset of these cells expresses Prlh and that enhancing Prlh-mediated neurotransmission f
Externí odkaz:
https://doaj.org/article/7ee988d06c344cb69da88198bf19969f
Autor:
Carly M. Darden, Srividya Vasu, Jordan Mattke, Yang Liu, Christopher J. Rhodes, Bashoo Naziruddin, Michael C. Lawrence
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104125- (2022)
Summary: Pancreatic islets respond to metabolic and inflammatory stress by producing hormones and other factors that induce adaptive cellular and systemic responses. Here we show that intracellular Ca2+ ([Ca2+]i) and ROS signals generated by high glu
Externí odkaz:
https://doaj.org/article/2e660b09feef429899f1e3fee307befa
Autor:
Hebah A. Sindi, Giusy Russomanno, Sandro Satta, Vahitha B. Abdul-Salam, Kyeong Beom Jo, Basma Qazi-Chaudhry, Alexander J. Ainscough, Robert Szulcek, Harm Jan Bogaard, Claire C. Morgan, Soni S. Pullamsetti, Mai M. Alzaydi, Christopher J. Rhodes, Roberto Piva, Christina A. Eichstaedt, Ekkehard Grünig, Martin R. Wilkins, Beata Wojciak-Stothard
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Pulmonary arterial hypertension is a severe lung disease characterised by progressive vascular remodelling. Here, the authors show that reduced signalling of flow-activated transcription factor KLF2 is a common feature of human PAH and that KLF2-regu
Externí odkaz:
https://doaj.org/article/4eebb969beec4b25a1d7906be6c74e47
Autor:
Brandon B. Boland, Rhianna C. Laker, Siobhan O'Brien, Sadichha Sitaula, Isabelle Sermadiras, Jens Christian Nielsen, Pernille Barkholt, Urmas Roostalu, Jacob Hecksher-Sørensen, Sara Rubek Sejthen, Ditte Dencker Thorbek, Arthur Suckow, Nicole Burmeister, Stephanie Oldham, Sarah Will, Victor G. Howard, Benji M. Gill, Philip Newton, Jacqueline Naylor, David C. Hornigold, Jotham Austin, Louise Lantier, Owen P. McGuinness, James L. Trevaskis, Joseph S. Grimsby, Christopher J. Rhodes
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101392- (2022)
Objective: Obesity-linked type 2 diabetes (T2D) is a worldwide health concern and many novel approaches are being considered for its treatment and subsequent prevention of serious comorbidities. Co-administration of glucagon like peptide 1 (GLP-1) an
Externí odkaz:
https://doaj.org/article/b325ef86371a42baa07ae1549ba9e3b0