Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Christopher J, Lengner"'
Autor:
Ning Li, Qin Zhu, Yuhua Tian, Kyung Jin Ahn, Xin Wang, Zvi Cramer, Justine Jou, Ian W. Folkert, Pengfei Yu, Stephanie Adams-Tzivelekidis, Priyanka Sehgal, Najia N. Mahmoud, Cary B. Aarons, Robert E. Roses, Andrei Thomas-Tikhonenko, Emma E. Furth, Ben Z. Stanger, Anil Rustgi, Malay Haldar, Bryson W. Katona, Kai Tan, Christopher J. Lengner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The initiation and progression of cancer are intricately linked to the tumor microenvironment (TME). Understanding the function of specific cancer-TME interactions poses a major challenge due in part to the complexity of the in vivo microenv
Externí odkaz:
https://doaj.org/article/27a70ad4c8a74c5881020e751a7a5388
Autor:
Young-Jun Choi, Melissa S. Kim, Joshua H. Rhoades, Nicolette M. Johnson, Corbett T. Berry, Sarah Root, Qijun Chen, Yuhua Tian, Rafael J. Fernandez, III, Zvi Cramer, Stephanie Adams-Tzivelekidis, Ning Li, F. Brad Johnson, Christopher J. Lengner
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 3, Pp 451-472 (2023)
Background & Aims: Dyskeratosis congenita (DC) is a telomere biology disorder caused primarily by mutations in the DKC1 gene. Patients with DC and related telomeropathies resulting from premature telomere dysfunction experience multiorgan failure. In
Externí odkaz:
https://doaj.org/article/097aee7b209740a1bf70038743eb0b74
Autor:
Kensuke Sugiura, Yasunori Masuike, Kensuke Suzuki, Alice E. Shin, Nozomu Sakai, Hisahiro Matsubara, Masayuki Otsuka, Peter A. Sims, Christopher J. Lengner, Anil K. Rustgi
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
The RNA-binding protein LIN28B is overexpressed in over 30% of patients with colorectal cancer (CRC) and is associated with poor prognosis. In the present study, we unraveled a potentially novel mechanism by which LIN28B regulates colonic epithelial
Externí odkaz:
https://doaj.org/article/4cc16e72c1d5417fbecfca91adb61af1
Autor:
Xiaolei Liu, William D. Jones, Mathieu Quesnel-Vallières, Sudhish A. Devadiga, Kristin Lorent, Alexander J. Valvezan, Rebecca L. Myers, Ning Li, Christopher J. Lengner, Yoseph Barash, Michael Pack, Peter S. Klein
Publikováno v:
Journal of Developmental Biology, Vol 11, Iss 3, p 29 (2023)
Neural crest (NC) is a unique vertebrate cell type arising from the border of the neural plate and epidermis that gives rise to diverse tissues along the entire body axis. Roberto Mayor and colleagues have made major contributions to our understandin
Externí odkaz:
https://doaj.org/article/f1611d5c12b54d1ba12ab6eacd305385
Autor:
Rafael Jesus Fernandez, Zachary JG Gardner, Katherine J Slovik, Derek C Liberti, Katrina N Estep, Wenli Yang, Qijun Chen, Garrett T Santini, Javier V Perez, Sarah Root, Ranvir Bhatia, John W Tobias, Apoorva Babu, Michael P Morley, David B Frank, Edward E Morrisey, Christopher J Lengner, F Brad Johnson
Publikováno v:
eLife, Vol 11 (2022)
Dyskeratosis congenita (DC) is a rare genetic disorder characterized by deficiencies in telomere maintenance leading to very short telomeres and the premature onset of certain age-related diseases, including pulmonary fibrosis (PF). PF is thought to
Externí odkaz:
https://doaj.org/article/5a2e0adc44d4496d8818d07ddfebb226
Autor:
Hongwon Kim, Hyeok Ju Park, Hwan Choi, Yujung Chang, Hanseul Park, Jaein Shin, Junyeop Kim, Christopher J. Lengner, Yong Kyu Lee, Jongpil Kim
Publikováno v:
Stem Cell Reports, Vol 12, Iss 3, Pp 518-531 (2019)
Summary: Recent advances in generating three-dimensional (3D) organoid systems from stem cells offer new possibilities for disease modeling and drug screening because organoids can recapitulate aspects of in vivo architecture and physiology. In this
Externí odkaz:
https://doaj.org/article/3bfa8e2be2c640df9fbbbf4da234bbe2
Autor:
Xiaole Sheng, Ziguang Lin, Cong Lv, Chunlei Shao, Xueyun Bi, Min Deng, Jiuzhi Xu, Christian F. Guerrero-Juarez, Mengzhen Li, Xi Wu, Ran Zhao, Xu Yang, Guilin Li, Xiaowei Liu, Qingyu Wang, Qing Nie, Wei Cui, Shan Gao, Hongquan Zhang, Zhihua Liu, Yingzi Cong, Maksim V. Plikus, Christopher J. Lengner, Bogi Andersen, Fazheng Ren, Zhengquan Yu
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107952- (2020)
Summary: A certain number of epithelial cells in intestinal crypts are DNA damage resistant and contribute to regeneration. However, the cellular mechanism underlying intestinal regeneration remains unclear. Using lineage tracing, we show that cells
Externí odkaz:
https://doaj.org/article/8a6eed3e68c3420e9380c482b91cf220
Autor:
Maryam Yousefi, Angela Nakauka-Ddamba, Corbett T. Berry, Ning Li, Jenna Schoenberger, Kamen P. Simeonov, Ryan J. Cedeno, Zhengquan Yu, Christopher J. Lengner
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 703-711 (2018)
Summary: Aging is a complex process associated with a decline in functionality of adult stem cells affecting tissue homeostasis and regeneration. Calorie restriction (CR) is the only experimental manipulation known to extend lifespan and reduce the i
Externí odkaz:
https://doaj.org/article/fae24ad16cae4f098e0b844d45d9bd30
Autor:
Ajeya Nandi, Rahul Debnath, Anupma Nayak, Tsun Ki Jerrick To, Gatha Thacker, Megan Reilly, Sanjeev Gumber, Ilias Karagounis, Ning Li, Christopher J. Lengner, Malay Haldar, Alana L. Welm, Andres M. Blanco, Christoforos Thomas, Rumela Chakrabarti
Publikováno v:
Cancer Res
Resistance to radiotherapy is a major obstacle for effective cancer treatment. Both cancer-associated fibroblasts (CAF) within the tumor microenvironment (TME) and Notch signaling are implicated in radioresistance, but their potential interrelationsh
Autor:
Klein, Xiaolei Liu, William D. Jones, Mathieu Quesnel-Vallières, Sudhish A. Devadiga, Kristin Lorent, Alexander J. Valvezan, Rebecca L. Myers, Ning Li, Christopher J. Lengner, Yoseph Barash, Michael Pack, Peter S.
Publikováno v:
Journal of Developmental Biology; Volume 11; Issue 3; Pages: 29
Neural crest (NC) is a unique vertebrate cell type arising from the border of the neural plate and epidermis that gives rise to diverse tissues along the entire body axis. Roberto Mayor and colleagues have made major contributions to our understandin