Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Christopher J, Kemp"'
Autor:
Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Michael Kubik, Nathan Kuhn, Matthew Benskey, Megan F. Duffy, Kelvin C. Luk, Caryl E. Sortwell
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Background Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alpha-synuclein (α-syn) inclusions (Lewy bodies), markers of neuroinflammation and the progressive loss of nigrostr
Externí odkaz:
https://doaj.org/article/5679db2e702a49868c1ad5fd724f257f
Autor:
Joseph R. Patterson, Joseph Kochmanski, Anna C. Stoll, Michael Kubik, Christopher J. Kemp, Megan F. Duffy, Kajene Thompson, Jacob W. Howe, Allyson Cole-Strauss, Nathan C. Kuhn, Kathryn M. Miller, Seth Nelson, Christopher U. Onyekpe, John S. Beck, Scott E. Counts, Alison I. Bernstein, Kathy Steece-Collier, Kelvin C. Luk, Caryl E. Sortwell
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-17 (2024)
Abstract Examination of early phases of synucleinopathy when inclusions are present, but long before neurodegeneration occurs, is critical to both understanding disease progression and the development of disease modifying therapies. The rat alpha-syn
Externí odkaz:
https://doaj.org/article/8bde4016617e4debb09532f2fc4a2cc0
Autor:
Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Jacob W. Howe, Kathy Steece-Collier, Kelvin C. Luk, Caryl E. Sortwell, Matthew J. Benskey
Publikováno v:
Neurobiology of Disease, Vol 191, Iss , Pp 106411- (2024)
Parkinson's disease (PD) pathology is characterized by alpha-synuclein (α-syn) aggregates, degeneration of dopamine neurons in the substantia nigra pars compacta (SNpc), and neuroinflammation. The presence of reactive glia correlates with deposition
Externí odkaz:
https://doaj.org/article/f5390f22412347b4b85630400c80d5a3
Autor:
Marwah Al-Aloosi, Amanda M. Prechtl, Payel Chatterjee, Brady Bernard, Christopher J. Kemp, Rachele Rosati, Robert L. Diaz, Lauren R. Appleyard, Shalini Pereira, Alex Rajewski, Amber McDonald, Eva J. Gordon, Carla Grandori
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
Patients presenting with stage 4 ovarian carcinoma, including low-grade serous disease, have a poor prognosis. Although platinum-based therapies can offer some response, these therapies are associated with many side effects, and treatment resistance
Externí odkaz:
https://doaj.org/article/fcc76ebb292445b4b3f929be800bb6b7
Autor:
Heidi J. Gray, Payel Chatterjee, Rachele Rosati, Lauren R. Appleyard, Grace J. Durenberger, Robert L. Diaz, Hallie A. Swan, Danielle Peretti, Maddy Pollastro, Trevor Ainge, Katannya Kapeli, Shalini Pereira, Astrid L. Margossian, Kalyan Banda, Barbara A. Goff, Elizabeth M. Swisher, Brady Bernard, Christopher J. Kemp, Carla Grandori
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-6 (2023)
Abstract Low-grade serous ovarian cancer (LGSOC) typically responds poorly to standard platinum-based chemotherapy and new therapeutic approaches are needed. We describe a remarkable response to targeted therapy in a patient with platinum-resistant,
Externí odkaz:
https://doaj.org/article/8a9cc59b3ce64630836df3b6b10cdaf8
Autor:
Joseph R. Patterson, Warren D. Hirst, Jacob W. Howe, Christopher P. Russell, Allyson Cole-Strauss, Christopher J. Kemp, Megan F. Duffy, Jared Lamp, Andrew Umstead, Michael Kubik, Anna C. Stoll, Irving E. Vega, Kathy Steece-Collier, Yi Chen, Anne C. Campbell, Catherine L. Nezich, Kelly E. Glajch, Caryl E. Sortwell
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-14 (2022)
Abstract β2-adrenoreceptor (β2AR) agonists have been associated with a decreased risk of developing Parkinson’s disease (PD) and are hypothesized to decrease expression of both alpha-synuclein mRNA (Snca) and protein (α-syn). Effects of β2AR ag
Externí odkaz:
https://doaj.org/article/1490e19ae927454fbbfea97a835eff52
Autor:
William Longabaugh, John Phan, Christopher J. Kemp, David Pot, Guangrong Qin, Bahar Tercan, Boris Aguilar, Taek-Kyun Kim, Ilya Shmulevich, Nyasha Chambwe
Publikováno v:
F1000Research, Vol 11 (2022)
Synthetic lethal interactions (SLIs), genetic interactions in which the simultaneous inactivation of two genes leads to a lethal phenotype, are promising targets for therapeutic intervention in cancer, as exemplified by the recent success of PARP inh
Externí odkaz:
https://doaj.org/article/7c4bbf65475849088bbbbf90b4c43749
Autor:
D. Luke Fischer, Peggy Auinger, John L. Goudreau, Katrina L. Paumier, Allyson Cole-Strauss, Christopher J. Kemp, Jack W. Lipton, Caryl E. Sortwell
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Parkinson's disease (PD) is heterogenous in its presentation, progression and response to therapies. Genetic polymorphisms may account for some of this variability. Several single nucleotide polymorphisms (SNPs) in the brain-derived neurotrophic fact
Externí odkaz:
https://doaj.org/article/fcf03407913048db829e89bd2b968d21
Autor:
Goldie Y.L. Lui, Reid Shaw, Franz X. Schaub, Isabella N. Stork, Kay E. Gurley, Caroline Bridgwater, Robert L. Diaz, Rachele Rosati, Hallie A. Swan, Tan A. Ince, Thomas C. Harding, Vijayakrishna K. Gadi, Barbara A. Goff, Christopher J. Kemp, Elizabeth M. Swisher, Carla Grandori
Publikováno v:
EBioMedicine, Vol 60, Iss , Pp 102988- (2020)
Background: Homologous recombination deficiencies (HRD) are present in approximately half of epithelial ovarian cancers, for which PARP inhibitors (PARPi) are becoming a preferred treatment option. However, a considerable proportion of these carcinom
Externí odkaz:
https://doaj.org/article/3e5e8f98aab5402f8b8ee8783a2b4b38
Autor:
Aysegul O. Gezer, Joseph Kochmanski, Sarah E. VanOeveren, Allyson Cole-Strauss, Christopher J. Kemp, Joseph R. Patterson, Kathryn M. Miller, Nathan C. Kuhn, Danielle E. Herman, Alyssa McIntire, Jack W. Lipton, Kelvin C. Luk, Sheila M. Fleming, Caryl E. Sortwell, Alison I. Bernstein
Publikováno v:
Neurobiology of Disease, Vol 141, Iss , Pp 104947- (2020)
Human and animal studies have shown that exposure to the organochlorine pesticide dieldrin is associated with increased risk of Parkinson's disease (PD). Previous work showed that developmental dieldrin exposure increased neuronal susceptibility to M
Externí odkaz:
https://doaj.org/article/212f253653d444c5bfd9ea221a1eac9e