Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christopher J, Drakeley"'
Autor:
Matthew Higgins, Mojca Kristan, Emma L. Collins, Louisa A. Messenger, Jamille G. Dombrowski, Leen N. Vanheer, Debbie Nolder, Christopher J. Drakeley, William Stone, Almahamoudou Mahamar, Teun Bousema, Michael Delves, Janvier Bandibabone, Sévérin N’Do, Chimanuka Bantuzeko, Bertin Zawadi, Thomas Walker, Colin J. Sutherland, Claudio R. F. Marinho, Mary M. Cameron, Taane G. Clark, Susana Campino
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Robust diagnostic tools and surveillance are crucial for malaria control and elimination efforts. Malaria caused by neglected Plasmodium parasites is often underestimated due to the lack of rapid diagnostic tools that can accurately detect t
Externí odkaz:
https://doaj.org/article/a62e65a32f43462287335f4c454f7c0a
Autor:
Ashley Osborne, Jody E. Phelan, Leen N. Vanheer, Alphaxard Manjurano, Jesse Gitaka, Christopher J. Drakeley, Akira Kaneko, Kiyoshi Kita, Susana Campino, Taane G. Clark
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Malaria has exhibited the strongest known selective pressure on the human genome in recent history and is the evolutionary driving force behind genetic conditions, such as sickle-cell disease, glucose-6-phosphatase deficiency, and some other
Externí odkaz:
https://doaj.org/article/a16d472dd2904e089c3a233382b7648b
Autor:
Matt Ravenhall, Susana Campino, Nuno Sepúlveda, Alphaxard Manjurano, Behzad Nadjm, George Mtove, Hannah Wangai, Caroline Maxwell, Raimos Olomi, Hugh Reyburn, Christopher J Drakeley, Eleanor M Riley, Taane G Clark, MalariaGEN
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007172 (2018)
Significant selection pressure has been exerted on the genomes of human populations exposed to Plasmodium falciparum infection, resulting in the acquisition of mechanisms of resistance against severe malarial disease. Many host genetic factors, inclu
Externí odkaz:
https://doaj.org/article/77a93404b1b749a594fbc28a3865dcda
Autor:
Ernest Diez Benavente, Paola Florez de Sessions, Robert W Moon, Anthony A Holder, Michael J Blackman, Cally Roper, Christopher J Drakeley, Arnab Pain, Colin J Sutherland, Martin L Hibberd, Susana Campino, Taane G Clark
Publikováno v:
PLoS Genetics, Vol 13, Iss 9, p e1007008 (2017)
The macaque parasite Plasmodium knowlesi is a significant concern in Malaysia where cases of human infection are increasing. Parasites infecting humans originate from genetically distinct subpopulations associated with the long-tailed (Macaca fascicu
Externí odkaz:
https://doaj.org/article/4a77442f2a2d450fb9afa6ae244a62b1
Autor:
Dr Matthew J Grigg, PhD, Jonathan Cox, PhD, Timothy William, FRCP, Jenarun Jelip, MBBS, Kimberly M Fornace, MSc, Patrick M Brock, PhD, Lorenz von Seidlein, PhD, Bridget E Barber, PhD, Prof Nicholas M Anstey, PhD, Tsin W Yeo, PhD, Prof Christopher J Drakeley, PhD
Publikováno v:
The Lancet Planetary Health, Vol 1, Iss 3, Pp e97-e104 (2017)
Background: The emergence of human malaria due to the monkey parasite Plasmodium knowlesi threatens elimination efforts in southeast Asia. Changes in land use are thought to be driving the rise in reported P knowlesi cases, but the role of individual
Externí odkaz:
https://doaj.org/article/f04b990cf79748c99a8a5a709fbad838
Autor:
Matthew J Grigg, Bridget E Barber, Jutta Marfurt, Mallika Imwong, Timothy William, Elspeth Bird, Kim A Piera, Ammar Aziz, Usa Boonyuen, Christopher J Drakeley, Jonathan Cox, Nicholas J White, Qin Cheng, Tsin W Yeo, Sarah Auburn, Nicholas M Anstey
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149519 (2016)
BACKGROUND:Malaria caused by zoonotic Plasmodium knowlesi is an emerging threat in Eastern Malaysia. Despite demonstrated vector competency, it is unknown whether human-to-human (H-H) transmission is occurring naturally. We sought evidence of drug se
Externí odkaz:
https://doaj.org/article/12492413a4594b4f97c7f0bde069e223
Autor:
Alphaxard Manjurano, Nuno Sepulveda, Behzad Nadjm, George Mtove, Hannah Wangai, Caroline Maxwell, Raimos Olomi, Hugh Reyburn, Eleanor M Riley, Christopher J Drakeley, Taane G Clark, MalariaGEN Consortium
Publikováno v:
PLoS Genetics, Vol 11, Iss 2, p e1004960 (2015)
X-linked Glucose-6-phosphate dehydrogenase (G6PD) A- deficiency is prevalent in sub-Saharan Africa populations, and has been associated with protection from severe malaria. Whether females and/or males are protected by G6PD deficiency is uncertain, d
Externí odkaz:
https://doaj.org/article/e9353f36c7a5467982dfadb0b1bd646c
Autor:
Maha Saeed, Will Roeffen, Neal Alexander, Christopher J Drakeley, Geoffrey A T Targett, Colin J Sutherland
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2280 (2008)
BackgroundThe asexual blood stages of the human malaria parasite Plasmodium falciparum produce highly immunogenic polymorphic antigens that are expressed on the surface of the host cell. In contrast, few studies have examined the surface of the gamet
Externí odkaz:
https://doaj.org/article/5141fbd8546e421c8806f6476ae35064
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 12, p e255 (2007)
Acquisition of partially protective immunity is a dominant feature of the epidemiology of malaria among exposed individuals. The processes that determine the acquisition of immunity to clinical disease and to asymptomatic carriage of malaria parasite
Externí odkaz:
https://doaj.org/article/4f8506d8a85a46d18358a7912eeca42c
Autor:
Colin J Sutherland, Rosalynn Ord, Sam Dunyo, Musa Jawara, Christopher J Drakeley, Neal Alexander, Rosalind Coleman, Margaret Pinder, Gijs Walraven, Geoffrey A T Targett
Publikováno v:
PLoS Medicine, Vol 2, Iss 4, p e92 (2005)
BackgroundResistance of malaria parasites to chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) is increasing in prevalence in Africa. Combination therapy can both improve treatment and provide important public health benefits if it curbs the sprea
Externí odkaz:
https://doaj.org/article/1533ac6ee2f743af89b09846b986bc8d