Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK

Autor: Fiona Hey, Catherine Andreadi, Catherine Noble, Bipin Patel, Hong Jin, Tamihiro Kamata, Kees Straatman, Jinli Luo, Kathryn Balmanno, David T.W. Jones, V. Peter Collins, Simon J. Cook, Christopher J. Caunt, Catrin Pritchard

Publikováno v: Heliyon, Vol 4, Iss 12, Pp e01065- (2018)

BRAF is a cytoplasmic protein kinase, which activates the MEK-ERK signalling pathway. Deregulation of the pathway is associated with the presence of BRAF mutations in human cancer, the most common being V600EBRAF, although structural rearrangements,

Externí odkaz: https://doaj.org/article/fd31fb97d68f4aaf961cf388c3e1c07c

Mechanisms of GnRH-induced extracellular signal-regulated kinase nuclear localization.

Autor: Christopher J Caunt, Rebecca M Perett, Robert C Fowkes, Craig A McArdle

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e40077 (2012)

Gonadotropin-releasing hormone receptors (GnRHR) mediate activation and nuclear translocation of the extracellular signal regulated kinases 1 and 2 (ERK) by phosphorylation on the TEY motif. This is necessary for GnRH to initiate transcriptional prog

Externí odkaz: https://doaj.org/article/e18885e77410470cade7adf1bb83764a

Information Transfer in Gonadotropin-releasing Hormone (GnRH) Signaling

Autor: Clive G. Bowsher, Craig A. McArdle, Thanh Pham, Kathryn Garner, George R. Pope, Christopher J. Caunt, Rebecca M. Perrett, Margaritis Voliotis, Krasimira Tsaneva-Atanasova

Publikováno v: Journal of Biological Chemistry. 291:2246-2259

Cell signaling pathways are noisy communication channels, and statistical measures derived from information theory can be used to quantify the information they transfer. Here we use single cell signaling measures to calculate mutual information as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2441e0a34fad547ae2b641a91bd5f317
https://doi.org/10.1074/jbc.m115.686964

Signaling to Extracellular Signal-regulated Kinase from ErbB1 Kinase and Protein Kinase C

Autor: Craig A. McArdle, Robert C. Fowkes, Christopher J. Caunt, Rebecca M. Perrett, Clive G. Bowsher, Krasimira Tsaneva-Atanasova

Publikováno v: Journal of Biological Chemistry. 288:21001-21014

Many extracellular signals act via the Raf/MEK/ERK cascade in which kinetics, cell-cell variability, and sensitivity of the ERK response can all influence cell fate. Here we used automated microscopy to explore the effects of ERK-mediated negative fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6446a29fd2593f7fda640e5206c05a88
https://doi.org/10.1074/jbc.m113.455345

Visualizing and quantitating the spatiotemporal regulation of Ras/ERK signaling by dual-specificity mitogen-activated protein phosphatases (MKPs)

Autor: Christopher J. Caunt, Stephen M. Keyse, Andrew M. Kidger

Publikováno v: Caunt, C J, Kidger, A M & Keyse, S M 2016, Visualizing and quantitating the spatiotemporal regulation of Ras/ERK signaling by dual-specificity mitogen-activated protein phosphatases (MKPs) . in R Pulido (ed.), Protein Tyrosine Phosphatases : Methods and Protocols . Methods in Molecular Biology, vol. 1447, Springer, pp. 197-215 . https://doi.org/10.1007/978-1-4939-3746-2_12
Methods in Molecular Biology ISBN: 9781493937448

The spatiotemporal regulation of the Ras/ERK pathway is critical in determining the physiological and pathophysiological outcome of signaling. Dual-specificity mitogen-activated protein kinase (MAPK) phosphatases (DUSPs or MKPs) are key regulators of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46614781c9e0b404f3334e91a6c1938
https://purehost.bath.ac.uk/ws/files/146949043/Methods_chapter_PDF.pdf