Zobrazeno 1 - 5
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pro vyhledávání: '"Christopher I. Pearson"'
Publikováno v:
The Journal of Organic Chemistry. 78:1098-1106
α-Lithiation of N-thiopivaloylazetidin-3-ol and subsequent electrophile trapping provides access to a range of 2-substituted 3-hydroxyazetidines with generally good trans-diastereoselectivity, aside from deuteration, which gives the cis-diastereoiso
Autor:
Barbara Odell, Ilya Kuprov, Christopher I. Pearson, Johannes Kloesges, Timothy D. W. Claridge, David M. Hodgson
Publikováno v:
Angewandte Chemie (International Ed. in English)
Anomalous NOESY cross-peaks that cannot be explained by dipolar cross-relaxation or chemical exchange are described for carbon-substituted aziridines. The origin of these is identified as scalar cross-relaxation of the first kind, as demonstrated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e23d493779bd5809cfcc0b532334b12
https://ora.ox.ac.uk/objects/uuid:d0cd1a8f-6d1c-4304-a93f-7211d244ad11
https://ora.ox.ac.uk/objects/uuid:d0cd1a8f-6d1c-4304-a93f-7211d244ad11
Publikováno v:
ChemInform. 45
s-BuLi-induced α-lithiation–elimination of LiOMe from N-Boc-3-methoxyazetidine and further in situ α-lithiation generates N-Boc-2-lithio-2-azetine which can be trapped with electrophiles, either directly (carbonyl or heteroatom electrophiles) or
Publikováno v:
Organic Letters
s-BuLi-induced α-lithiation-elimination of LiOMe from N-Boc-3-methoxyazetidine and further in situ α-lithiation generates N-Boc-2-lithio-2-azetine which can be trapped with electrophiles, either directly (carbonyl or heteroatom electrophiles) or af
Publikováno v:
ChemInform. 44
Treatment of the azetidinol (I) with sBuLi followed by reaction with various electrophiles results in stereoselective formation of 2,3-trans-substituted derivatives with exception of CD3OD which predominantly yields the cis-product.