Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christopher I. Ho"'
Autor:
John S. A. Mattick, Robin E. Bromley, Kaylee J. Watson, Ricky S. Adkins, Christopher I. Holt, Jarrett F. Lebov, Benjamin C. Sparklin, Tyonna S. Tyson, David A. Rasko, Julie C. Dunning Hotopp
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT RNA transcripts are potential therapeutic targets, yet bacterial transcripts have uncharacterized biodiversity. We developed an algorithm for transcript prediction called tp.py using it to predict transcripts (mRNA and other RNAs) in Escheri
Externí odkaz:
https://doaj.org/article/d0edc818c52849dfb46e0614f9812657
Publikováno v:
Hypertension. 54:1353-1359
We investigated the ability of angiotensin II type 1 (AT1) receptor blockers with peroxisome proliferator-activated receptor (PPAR)-gamma agonist activity (telmisartan and irbesartan) and AT1 receptor blockers devoid of PPARgamma agonist activity (ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bc485ad95d5e1729dc3ee6d25a692dc
https://doi.org/10.1161/hypertensionaha.109.138750
https://doi.org/10.1161/hypertensionaha.109.138750
Publikováno v:
Journal of Hypertension. 26:973-980
BACKGROUND Few studies have directly compared the effects of different angiotensin receptor blockers (ARBs) on mechanisms involved in the pathogenesis of cardiovascular disease. METHODS We studied the ability of different ARBs to inhibit the prolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487c14c2f80c9eb7359291d20d7f6e0d
https://doi.org/10.1097/hjh.0b013e3282f56ba5
https://doi.org/10.1097/hjh.0b013e3282f56ba5
Autor:
Vaclav Zidek, Theodore W. Kurtz, Marek Vrbacký, Michal Pravenec, Olena Oliyarnyk, Tomáš Mráček, Petr Mlejnek, Ludmila Kazdova, Christopher I. Ho, Nathan Qi, Ken Sugimoto, Jiaming Wang, Vladimír Landa, Ivan Mikšík, Kristyna Dudová-Mothejzikova, Masaya Hyakukoku, Petr Pecina, Zdenek Drahota, Alena Vojtiskova, Josef Houstek
Publikováno v:
Genome Research. 17:1319-1326
Recently, the relationship of mitochondrial DNA (mtDNA) variants to metabolic risk factors for diabetes and other common diseases has begun to attract increasing attention. However, progress in this area has been limited because (1) the phenotypic ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3472e838ada28ef5612220cc83e7e14c
https://doi.org/10.1101/gr.6548207
https://doi.org/10.1101/gr.6548207
Autor:
Theodore W. Kurtz, Cassia S. Mizuno, Prashant V. Desai, Stephen C. Benson, Akshay Patny, Christopher I. Ho, Amar G. Chittiboyina, Meenakshi S. Venkatraman, Mitchell A. Avery, Harrihar A. Pershadsingh
Publikováno v:
Journal of Medicinal Chemistry. 49:4072-4084
A series of novel derivatives of potent antioxidant vitamin, alpha-lipoic acid, and related analogues were designed, synthesized, and evaluated for their PPARgamma agonist activities. Compounds 9a and the water soluble analogue11e were found to be po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9dc393555a7c7246dea922bb7402884
https://doi.org/10.1021/jm0510880
https://doi.org/10.1021/jm0510880
Publikováno v:
Journal of hypertension. 29(12)
Azilsartan medoxomil is a newly approved angiotensin receptor blocker (ARB) reported to lower 24-h blood pressure more effectively than maximally recommended doses of older ARBs. Although azilsartan is considered to be an unusually potent angiotensin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d14e32ad1127ba54dca37f5d3098a926
https://pubmed.ncbi.nlm.nih.gov/21986624
https://pubmed.ncbi.nlm.nih.gov/21986624
Autor:
Harrihar A. Pershadsingh, Meenakshi S. Venkatraman, Amar G. Chittiboyina, Stephen C. Benson, Charles N. Ellis, Josef G. Meingassner, Theodore W. Kurtz, Christopher I. Ho, James Varani, Mitchell A. Avery
Publikováno v:
Archives of Dermatological Research. 296
Novel thiazolidinedione derivatives of the potent antioxidant, alpha-lipoic (thioctic, 1,2-dithiolane) acid, were prepared. The prototype N-(2-[4-[2,4-dioxo(1,3-thiazolidin-5-yl)methyl]phenoxy]ethyl)-5-(1,2-dithiolan-3-yl)- N-methylpentanamide (desig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cc592eeaecea522ada2365c95bbe1ff
https://doi.org/10.1007/s00403-004-0480-5
https://doi.org/10.1007/s00403-004-0480-5
Autor:
Mitchell A. Avery, Prashant V. Desai, Jiaming Wang, N. Qi, Amar G. Chittiboyina, Stephen C. Benson, Christopher I. Ho, Michal Pravenec, Harrihar A. Pershadsingh, Theodore W. Kurtz
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 43(5)
The metabolic syndrome is a common precursor of cardiovascular disease and type 2 diabetes that is characterized by the clustering of insulin resistance, dyslipidemia, and increased blood pressure. In humans, mutations in the peroxisome proliferator-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8551cc2dd0d16a8eff3fccac9dfca93
https://pubmed.ncbi.nlm.nih.gov/15007034
https://pubmed.ncbi.nlm.nih.gov/15007034
Autor:
Mitchell A. Avery, Narasimharao Bhagavathula, Amar G. Chittiboyina, Theodore W. Kurtz, Harrihar A. Pershadsingh, Kamalakar C. Nerusu, Christopher I. Ho, Stephen C. Benson, Charles N. Ellis, Ashish Lal, James Varani
Publikováno v:
The Journal of investigative dermatology. 122(1)
This study was undertaken to evaluate the effects of thiazolidinediones (TZD) on keratinocyte proliferation, motility, and matrix metalloproteinase (MMP) production. Rosiglitazone (a potent TZD) inhibited both proliferation and motility as well as el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2942421358c44332e8a77e054fb375
https://pubmed.ncbi.nlm.nih.gov/14962101
https://pubmed.ncbi.nlm.nih.gov/14962101
Autor:
Meenakshi S, Venkatraman, Amar, Chittiboyina, Josef, Meingassner, Christopher I, Ho, James, Varani, Charles N, Ellis, Mitchell A, Avery, Harrihar A, Pershadsingh, Theodore W, Kurtz, Stephen C, Benson
Publikováno v:
Archives of dermatological research. 296(3)
Novel thiazolidinedione derivatives of the potent antioxidant, alpha-lipoic (thioctic, 1,2-dithiolane) acid, were prepared. The prototype N-(2-[4-[2,4-dioxo(1,3-thiazolidin-5-yl)methyl]phenoxy]ethyl)-5-(1,2-dithiolan-3-yl)- N-methylpentanamide (desig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1342f738d1011b4085f90cfc29b84a3
https://pubmed.ncbi.nlm.nih.gov/15221328
https://pubmed.ncbi.nlm.nih.gov/15221328