Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Christopher I Moore"'
Publikováno v:
eLife, Vol 9 (2020)
Predictive models can enhance the salience of unanticipated input. Here, we tested a key potential node in neocortical model formation in this process, layer (L) 6, using behavioral, electrophysiological and imaging methods in mouse primary somatosen
Externí odkaz:
https://doaj.org/article/5725441af90349b4b204af8a1c988c10
Autor:
Samuel A Neymotin, Dylan S Daniels, Blake Caldwell, Robert A McDougal, Nicholas T Carnevale, Mainak Jas, Christopher I Moore, Michael L Hines, Matti Hämäläinen, Stephanie R Jones
Publikováno v:
eLife, Vol 9 (2020)
Magneto- and electro-encephalography (MEG/EEG) non-invasively record human brain activity with millisecond resolution providing reliable markers of healthy and disease states. Relating these macroscopic signals to underlying cellular- and circuit-lev
Externí odkaz:
https://doaj.org/article/e8b0e0e82062488c816b690cec9072e8
Publikováno v:
eLife, Vol 6 (2017)
Beta oscillations (15-29Hz) are among the most prominent signatures of brain activity. Beta power is predictive of healthy and abnormal behaviors, including perception, attention and motor action. In non-averaged signals, beta can emerge as transient
Externí odkaz:
https://doaj.org/article/780fb82c32754a2bba324682fb0e87a5
Autor:
Christopher A. Deister, Alexander I. Moore, Jakob Voigts, Sophia Bechek, Rebecca Lichtin, Tyler C. Brown, Christopher I. Moore
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114233- (2024)
Summary: Perceptual success depends on fast-spiking, parvalbumin-positive interneurons (FS/PVs). However, competing theories of optimal rate and correlation in pyramidal (PYR) firing make opposing predictions regarding the underlying FS/PV dynamics.
Externí odkaz:
https://doaj.org/article/b93473522cb44156bc3dae04114fd1a2
Publikováno v:
Frontiers in Human Neuroscience, Vol 4 (2010)
Selective optogenetic drive of fast spiking interneurons (FS) leads to enhanced local field potential (LFP) power across the traditional gamma frequency band (20-80Hz; Cardin et al., 2009). In contrast, drive to regular-spiking pyramidal cells (RS) e
Externí odkaz:
https://doaj.org/article/a71cd9db717548f3bf7d4587f3bc022d
Publikováno v:
Frontiers in Human Neuroscience, Vol 4 (2010)
Gamma oscillations in neocortex are hypothesized to improve information transmission between groups of neurons. We recently showed that optogenetic drive of fast-spiking interneurons (FS) at 40 Hz in mouse neocortex in vivo modulates the spike count
Externí odkaz:
https://doaj.org/article/5ad7ed3010d5447fbec5ed5503e7ce1e
Autor:
Mansi Prakash, Jeremy Murphy, Robyn St Laurent, Nina Friedman, Emmanuel L. Crespo, Andreas Bjorefeldt, Akash Pal, Yuvraj Bhagat, Julie A. Kauer, Nathan C. Shaner, Diane Lipscombe, Christopher I. Moore, Ute Hochgeschwender
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Prakash et al. develop an approach to control synaptically connected elements using bioluminescent light, in which Luciferase-generated light, originating from a presynaptic axon terminal, modulates an opsin in its postsynaptic target to form an ‘o
Externí odkaz:
https://doaj.org/article/466740bf581a4a9e9e4cf7688016fe99
Autor:
Emmanuel L. Crespo, Mansi Prakash, Andreas Bjorefeldt, William E. Medendorp, Nathan C. Shaner, Diane Lipscombe, Christopher I. Moore, Ute Hochgeschwender
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100667- (2021)
Summary: Bioluminescent optogenetics (BL-OG) allows activation of photosensory proteins, such as opsins, by either fiberoptics or by administering a luciferin. BL-OG thus confers both optogenetic and chemogenetic access within the same genetically ta
Externí odkaz:
https://doaj.org/article/3c21176793034b0dae2223b29eebc3f3
Autor:
William E. Medendorp, Andreas Bjorefeldt, Emmanuel L. Crespo, Mansi Prakash, Akash Pal, Madison L. Waddell, Christopher I. Moore, Ute Hochgeschwender
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102157- (2021)
Summary: In genetic and pharmacological models of neurodevelopmental disorders, and human data, neural activity is altered within the developing neocortical network. This commonality begs the question of whether early enhancement in excitation might
Externí odkaz:
https://doaj.org/article/2fac34280f43468297b5619b71767bfc
Autor:
Brian W. LeBlanc, Brent Cross, Kelsey A. Smith, Catherine Roach, Jimmy Xia, Yu-Chieh Chao, Joshua Levitt, Suguru Koyama, Christopher I. Moore, Carl Y. Saab
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract We tested the relation between pain behavior, theta (4–8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is pro
Externí odkaz:
https://doaj.org/article/1294ec178cf74cba946d2b0729643c9a