Brazilin is a natural product inhibitor of the NLRP3 inflammasome

Autor: Emily McMahon, Sherihan El-Sayed, Jack Green, Christopher Hoyle, Lorna FitzPatrick, Emma V. Jones, Eve Corrie, Rebecca L. Kelly, Mairi Challinor, Sally Freeman, Richard A. Bryce, Catherine B. Lawrence, David Brough, Paul R. Kasher

Publikováno v: iScience, Vol 27, Iss 2, Pp 108968- (2024)

Summary: Excessive or aberrant NLRP3 inflammasome activation has been implicated in the progression and initiation of many inflammatory conditions; however, currently no NLRP3 inflammasome inhibitors have been approved for therapeutic use in the clin

Externí odkaz: https://doaj.org/article/0f496b494bea49a4bf551e605784fa33

FMDTOOLS: A Fault propagation Toolkit for Resilience Assessment in Early Design

Autor: Daniel Hulse, Hannah Walsh, Andy Dong, Christopher Hoyle, Irem Tumer, Chetan Kulkarni, Kai Goebel

Publikováno v: International Journal of Prognostics and Health Management, Vol 12, Iss 3 (2021)

Incorporating resilience in design is important for the long-term viability of complex engineered systems. Complex aerospace systems, for example, must ensure safety in the event of hazards resulting from part failures and external circumstances whil

Externí odkaz: https://doaj.org/article/67d8a8f518bd4bb7831109f8e783baaf

Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome

Autor: Bali Lee, Christopher Hoyle, Rose Wellens, Jack P. Green, Fatima Martin-Sanchez, Daniel M. Williams, Billie J. Matchett, Paula I. Seoane, Hayley Bennett, Antony Adamson, Gloria Lopez-Castejon, Martin Lowe, David Brough

Publikováno v: Lee, B, Hoyle, C, Wellens, R, Green, J P, Martin-Sanchez, F, Williams, D M, Matchett, B J, Seoane, P I, Bennett, H, Adamson, A, Lopez-Castejon, G, Lowe, M & Brough, D 2023, ' Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome ', Science Signaling, vol. 16, no. 773 . https://doi.org/10.1126/scisignal.abm7134

Inflammation driven by the NLRP3 inflammasome is coordinated through multiple signaling pathways and is regulated by subcellular organelles. Here, we tested the hypothesis that NLRP3 senses disrupted endosome trafficking to trigger inflammasome forma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af561ca983c5ec69eee329df91be13e
https://doi.org/10.1126/scisignal.abm7134

Contributors

Autor: Antonio Abbate, Ivona Aksentijevich, Marcelo Pires Amaral, Magaiver Andrade-Silva, Diego Angosto-Bazarra, Luca Antonioli, Kübra Aral, Juan I. Aróstegui, Jillian Barlow, Laura Benvenuti, Nunzia Bernardini, Massimo Bertinaria, Monika Biasizzo, Karina Ramalho Bortoluci, Dave Boucher, Laura Migliari Branco, David Brough, Petr Broz, Clare E. Bryant, Mark Cahill, Matthew Campbell, Soo Jung Cho, Shelbi Christgen, Rebecca C. Coll, Isabelle Couillin, Brianna Cyr, Sarah Dalmon, Juan Pablo de Rivero Vaccari, Francesco Di Virgilio, Andrea Dorfleutner, Sarah L. Doyle, Vanessa D'Antongiovanni, Ariel E. Feldstein, Matteo Fornai, Carlos García-Palenciano, Simone Gastaldi, Matthias Geyer, François Ghiringhelli, Anna Lisa Giuliani, José Manuel González-Navajas, Iva Hafner-Bratkovič, Shaima'a Hamarsheh, Michael T. Heneka, Thomas Henry, Jun-ichi Hikima, Inga V. Hochheiser, Alexander Hogg, Alexander Hooftman, Christopher Hoyle, Yin Huang, Sarah Huot-Marchand, Laura Hurtado-Navarro, Sushmita Jha, Thirumala-Devi Kanneganti, Benedikt Kaufmann, Andrea D. Kim, Nataša Kopitar-Jerala, Jordana Kron, Silvia Lucena Lage, Beatriz Lozano-Ruiz, Elisabetta Marini, Billie Matchett, Adolfo G. Mauro, Eleonora Mezzaroma, Michael R. Milward, Ingrid Kazue Mizuno Watanabe, Natsuki Morimoto, Sandip Mukherjee, Mar Orzáez, Luke A.J. O'Neill, Pablo Pelegrín, Carolina Pellegrini, Anaïs Perrichet, Joanna Picó, Nicola Potere, Alexander Pronko, Kishore Aravind Ravichandran, Nicolas Riteau, Kim S. Robinson, Cédric Rébé, Fadi N. Salloum, Mónica Sancho, Andrew Sandstrom, Niels Olsen Saraiva Câmara, Florian I. Schmidt, Liang Shan, Eoin Silke, Paula M. Soriano-Teruel, Christian Stehlik, Heather Stout-Delgado, Arianne L. Theiss, Jenny P.-Y. Ting, Stefano Toldo, Elviche L. Tsakem, Rebecca E. Tweedell, Amalia Tzoumpa, K. Venuprasad, Rose Wellens, Robert Zeiser, Franklin L. Zhong, Alessia Zotta

Publikováno v: Inflammasome Biology ISBN: 9780323918022

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1df40277879d3530be000cf63f0ec15f
https://doi.org/10.1016/b978-0-323-91802-2.01002-1

Exploring Architectures for Integrated Resilience Optimization

Autor: Daniel Hulse, Christopher Hoyle, Arpan Biswas, Chetan S. Kulkarni, Irem Y. Tumer, Kai Goebel

Publikováno v: Journal of Aerospace Information Systems. 18:665-678

To achieve system resilience, one can leverage high-level design features (e.g., redundancies and fail-safes), adjust operational profiles (e.g., load or trajectory), and use appropriate contingenc...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fd442fbce4a6df096fe9bc25ef44719
https://doi.org/10.2514/1.i010942