Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christopher Holton"'
Autor:
Saira Hameed, Michael Patterson, Waljit S. Dhillo, Sofia A. Rahman, Yue Ma, Christopher Holton, Apostolos Gogakos, Giles S.H. Yeo, Brian Y.H. Lam, Joseph Polex-Wolf, Wiebke Fenske, Jimmy Bell, Jelena Anastasovska, Jacques Samarut, Stephen R. Bloom, J.H. Duncan Bassett, Graham R. Williams, James V. Gardiner
Publikováno v:
Cell Reports, Vol 19, Iss 11, Pp 2202-2209 (2017)
The obesity epidemic is a significant global health issue. Improved understanding of the mechanisms that regulate appetite and body weight will provide the rationale for the design of anti-obesity therapies. Thyroid hormones play a key role in metabo
Externí odkaz:
https://doaj.org/article/d368c488aef54187b714d5c151f12af6
Autor:
Philip R. Holland, Lauren C Strother, Christopher Holton, Peter J. Goadsby, Amynah A. Pradhan, Isaac Dripps
Publikováno v:
British Journal of Pharmacology
Background and purpose There is a major unmet need to develop new therapies for migraine. We have previously demonstrated the therapeutic potential of the acid-sensing ion channel (ASIC) blockade in migraine, via an ASIC1 mechanism. ASIC3 is expresse
Autor:
Andrew McCarthy, Elaine Shanks, Penny Oxley, Nicola Hanley, Brian J. Eastwood, Keith A. Wafford, Christopher Holton, Aidan Nickerson, Tracey K. Murray
Publikováno v:
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-15 (2020)
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-15 (2020)
Background Disturbed sleep is associated with cognitive decline in neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD). The progressive sequence of how neurodegeneration affects aspects of sleep architectur
Autor:
Errol Richardson, Mariana Norton, Gaelle Carrat, Sufyan Hussain, Risheka Ratnasabapathy, Waljit S. Dhillo, Yue Ma, Chioma Izzi-Engbeaya, Backer Ivan De, James Gardiner, Marie-Sophie Nguyen-Tu, Blanche Schwappach, Christopher Holton, Guy A. Rutter
Publikováno v:
Endocrine Abstracts.
Publikováno v:
Medicine in Drug Discovery, Vol 7, Iss, Pp 100055-(2020)
Since the initial characterisation of the orexin/hypocretin system, the noradrenergic locus coeruleus (LC) has been a key focus due to its high expression of orexin receptors. Direct application of orexin A (OX-A) into the LC increases neural activit
Autor:
Yue, Ma, Risheka, Ratnasabapathy, Chioma, Izzi-Engbeaya, Marie-Sophie, Nguyen-Tu, Errol, Richardson, Sufyan, Hussain, Ivan, De Backer, Christopher, Holton, Mariana, Norton, Gaelle, Carrat, Blanche, Schwappach, Guy A, Rutter, Waljit S, Dhillo, James, Gardiner
Publikováno v:
Diabetes, Obesity & Metabolism
Aims To investigate the role of arcuate glucokinase (GK) in the regulation of glucose homeostasis. Materials and methods A recombinant adeno‐associated virus expressing either GK or an antisense GK construct was used to alter GK activity specifical
Autor:
S.R. Bloom, Errol Richardson, Syed Sufyan Hussain, Gavin A. Bewick, David Carling, Shuai Zhang, Waljit S. Dhillo, James Gardiner, Ivan De Backer, Christopher Holton, Niki Buckley, Yue Ma
Publikováno v:
Journal of Clinical Investigation. 125:337-349
The brain relies on a constant supply of glucose, its primary fuel, for optimal function. A taste-independent mechanism within the CNS that promotes glucose delivery to the brain has been postulated to maintain glucose homeostasis; however, evidence
Publikováno v:
International Journal of Offender Therapy and Comparative Criminology. 19:263-269