Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Christopher Haslett"'
Autor:
Brian J. McHugh, Jillian Stephen, Calum T. Robb, Sarah Fox, Tiina Kipari, Jennifer A. Cartwright, Christopher Haslett, Rodger Duffin, Christopher D. Lucas, Adriano G. Rossi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Cyclin-dependent kinase (CDK) inhibitor drugs (CDKi), such as R-roscovitine and AT7519, induce neutrophil apoptosis in vitro and enhance the resolution of inflammation in a number of in vivo models. This class of compounds are potential novel therape
Externí odkaz:
https://doaj.org/article/dd647f36378d4af591bcb325f83313a5
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40346 (2012)
Lung cancer is one of the most common fatal diseases in the developed world. The disease is rarely cured by currently available therapies, with an overall survival rate of ∼10%. Characterizing novel proteins that offer crucial insights into the pro
Externí odkaz:
https://doaj.org/article/e299962e8e6847acb0ac399a92425375
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33142 (2012)
Control of macrophage capacity for apoptotic cell clearance by soluble mediators such as cytokines, prostaglandins and lipoxins, serum proteins, and glucocorticoids may critically determine the rate at which inflammation resolves. Previous studies su
Externí odkaz:
https://doaj.org/article/72d1e908db5e45a385f7db7160b83b7d
Autor:
Ana L Alessandri, Rodger Duffin, Andrew E Leitch, Christopher D Lucas, Tara A Sheldrake, David A Dorward, Nik Hirani, Vanessa Pinho, Lirlândia Pires de Sousa, Mauro M Teixeira, John F Lyons, Christopher Haslett, Adriano G Rossi
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25683 (2011)
Eosinophils not only defend the body against parasitic infection but are also involved in pathological inflammatory allergic diseases such as asthma, allergic rhinitis and contact dermatitis. Clearance of apoptotic eosinophils by macrophages is a key
Externí odkaz:
https://doaj.org/article/c1a3b7d4cbea493cac69e41a520b8a9c
Autor:
Tom Quinn, Annya Bruce, Alicia Megia-Fernandez, Emma Scholefield, Sheelagh Duncan, Gareth O. S. Williams, Jonathan Knight, Tim A. Birks, Michael G. Tanner, James M. Stone, Ahsan R. Akram, Nikola Krstajić, Muhammed Ucuncu, Christopher Haslett, Harry A. C. Wood, Mark Bradley, Kerrianne Harrington, Adam Marshall, Tushar R. Choudhary, Helen E. Parker, Bethany Mills, Kevin Dhaliwal, Irene Young, Dominic Norberg
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging
Mills, B, Megia-Fernandez, A, Norberg, D, Duncan, S, Marshall, A, Akram, A R, Quinn, T, Young, I, Bruce, A M, Scholefield, E, Williams, G O S, Krstajić, N, Choudhary, T R, Parker, H E, Tanner, M G, Harrington, K, Wood, H A C, Birks, T A, Knight, J C, Haslett, C, Dhaliwal, K, Bradley, M, Ucuncu, M & Stone, J M 2020, ' Molecular detection of Gram-positive bacteria in the human lung through an optical fiber–based endoscope ', European Journal of Nuclear Medicine and Molecular Imaging, vol. N/A, pp. 1-8 . https://doi.org/10.1007/s00259-020-05021-4
Mills, B, Megia-Fernandez, A, Norberg, D, Duncan, S, Marshall, A, Akram, A R, Quinn, T, Young, I, Bruce, A M, Scholefield, E, Williams, G O S, Krstajić, N, Choudhary, T R, Parker, H E, Tanner, M G, Harrington, K, Wood, H A C, Birks, T A, Knight, J C, Haslett, C, Dhaliwal, K, Bradley, M, Ucuncu, M & Stone, J M 2020, ' Molecular detection of Gram-positive bacteria in the human lung through an optical fiber–based endoscope ', European Journal of Nuclear Medicine and Molecular Imaging, vol. N/A, pp. 1-8 . https://doi.org/10.1007/s00259-020-05021-4
Purpose The relentless rise in antimicrobial resistance is a major societal challenge and requires, as part of its solution, a better understanding of bacterial colonization and infection. To facilitate this, we developed a highly efficient no-wash r
Publikováno v:
The American Journal of Pathology
Zhang, A, Lacy-Hulbert, A, Anderton, S, Haslett, C & Savill, J 2020, ' Apoptotic cell-directed resolution of lung inflammation requires myeloid αv integrin-mediated induction of regulatory T lymphocytes ', American Journal of Pathology . https://doi.org/10.1016/j.ajpath.2020.02.010
Zhang, A, Lacy-Hulbert, A, Anderton, S, Haslett, C & Savill, J 2020, ' Apoptotic cell-directed resolution of lung inflammation requires myeloid αv integrin-mediated induction of regulatory T lymphocytes ', American Journal of Pathology . https://doi.org/10.1016/j.ajpath.2020.02.010
Intratracheal instillation of apoptotic cells enhances resolution of experimental lung inflammation by incompletely understood mechanisms. We report that this intervention induces functional regulatory T lymphocytes (Tregs) in mouse lung experimental
Autor:
Alicia Megia-Fernandez, Ahsan R. Akram, Veronique Dentan, Adam Marshall, Francois Lacombe, Nik Hirani, Bethany Mills, Chesney Michaels, Joanne Mair, Sunay V. Chankeshwara, Amy Miele, Annya Bruce, Christopher Haslett, Nathan J. Knighton, Emma Scholefield, Mark Bradley, Bruce C. McGorum, Robert W. Hitchcock, Kevin Dhaliwal, Tom Vercauteren
Publikováno v:
Megia-Fernandez, A, Marshall, A, Akram, A R, Mills, B, Chankeshwara, S, Scholefield, E, Miele, A, McGorum, B, Michaels, C, Knighton, N, Vercauteren, T, Lacombe, F, Dentan, V, Bruce, A, Mair, J, Hitchcock, R, Hirani, N, Haslett, C, Bradley, M & Dhaliwal, K 2021, ' Optical detection of distal lung enzyme activity in human inflammatory lung disease. ', Biomedical Engineering Frontiers . https://doi.org/10.34133/2021/9834163
BME Frontiers, Vol 2021 (2021)
BME Frontiers, Vol 2021 (2021)
Objective and Impact Statement. There is a need to develop platforms delineating inflammatory biology of the distal human lung. We describe a platform technology approach to detect in situ enzyme activity and observe drug inhibition in the distal hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fdd1b780129defd64b2a9b021099071
https://hdl.handle.net/20.500.11820/ad6dc76e-87f7-4478-80df-0f7e4ddffca6
https://hdl.handle.net/20.500.11820/ad6dc76e-87f7-4478-80df-0f7e4ddffca6
Autor:
Thane A. Campbell, James W. Dear, Annya Bruce, Bethany Mills, Tashfeen Walton, Emma Scholefield, Adam Marshall, Neil Q. McDonald, Thomas H. Craven, Timothy S. Walsh, Duncan Humphries, Ahsan R. Akram, Kevin Dhaliwal, David E. Newby, Christopher Haslett, Joanne Mair, Adam T. Hill
Publikováno v:
Craven, T H, Walton, T, Akram, A R, Scholefield, E, Mcdonald, N, Marshall, A D L, Humphries, D C, Mills, B, Campbell, T A, Bruce, A, Mair, J, Dear, J W, Newby, D E, Hill, A T, Walsh, T S, Haslett, C & Dhaliwal, K 2021, ' Activated neutrophil fluorescent imaging technique for human lungs ', Scientific Reports, vol. 11, no. 1 . https://doi.org/10.1038/s41598-020-80083-w
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Neutrophil activation is an integral process to acute inflammation and is associated with adverse clinical sequelae. Identification of neutrophil activation in real time in the lungs of patients may permit biological stratification of patients in oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856a21122b702775030cfd15054a6b98
https://www.pure.ed.ac.uk/ws/files/191779842/s41598_020_80083_w_1_.pdf
https://www.pure.ed.ac.uk/ws/files/191779842/s41598_020_80083_w_1_.pdf
Autor:
Jingang Gui, Ian Dransfield, Jürgen Schwarze, Rodger Duffin, Adriano G. Rossi, Philippe M D Potey, Christopher Haslett, Jennifer M Felton, David A. Dorward, Ruth W. Craig, Christopher D. Lucas, Calum T. Robb, Jennifer A Cartwright
Publikováno v:
Felton, J M, Dorward, D A, Cartwright, J, Potey, P M D, Robb, C T, Gui, J, Craig, R W, Schwarze, J, Haslett, C, Duffin, R, Dransfield, I, Lucas, C D & Rossi, A G 2020, ' Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation ', Thorax, vol. 75, no. 7, pp. 600-605 . https://doi.org/10.1136/thoraxjnl-2019-213204
Thorax
Thorax
Eosinophils are key effector cells in allergic diseases. Here we investigated Mcl-1 (an anti-apoptotic protein) in experimental allergic airway inflammation using transgenic overexpressing human Mcl-1 mice (hMcl-1) and reducing Mcl-1 by a cyclin-depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5590db05029951e9c4ed70b8e912cdc2
https://hdl.handle.net/20.500.11820/6740e9e8-1b83-4e77-ae17-b57217d8e829
https://hdl.handle.net/20.500.11820/6740e9e8-1b83-4e77-ae17-b57217d8e829
Autor:
Mark Bradley, Paul A. Corris, Andrew J. Fisher, Timothy S. Walsh, Tashfeen Aslam, Ahsan R. Akram, Thomas H. Craven, Emma Scholefield, Neil Q. McDonald, Calum Gray, Christopher Haslett, David Collie, Marc Vendrell, Kevin Dhaliwal, Nicolaos Avlonitis
Publikováno v:
Akram, A R, Avlonitis, N, Scholefield, E, Vendrell Escobar, M, McDonald, N, Aslam, T, Craven, T H, Gray, C, Collie, D S, Fisher, A J, Corris, P, Walsh, T, Haslett, C, Bradley, M & Dhaliwal, K 2019, ' Enhanced avidity from a multivalent fluorescent antimicrobial peptide enables pathogen detection in a human lung model. ', Scientific Reports, vol. 9, 8422 (2019), pp. 1-10 . https://doi.org/10.1038/s41598-019-44804-0
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Rapid in situ detection of pathogens coupled with high resolution imaging in the distal human lung has the potential to provide new insights and diagnostic utility in patients in whom pneumonia is suspected. We have previously described an antimicrob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb241bdb5a01380c824e4bd8c687ec3
https://www.pure.ed.ac.uk/ws/files/96286020/Enhanced_avidity_from_a_multivalent_....pdf
https://www.pure.ed.ac.uk/ws/files/96286020/Enhanced_avidity_from_a_multivalent_....pdf