Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Christopher H.C. Tie"'
Autor:
Liane Fernandes, Annemarthe G. van der Veen, Petra Mlcochova, Christopher H.C. Tie, Ravindra K. Gupta, Helen M. Rowe, Rocio Enriquez-Gasca, James Holt, Kathleen H. Burns, Hale Tunbak, Poppy A Gould, Pierre V. Maillard, Evangelos Giampazolias
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, 11(1). NATURE PORTFOLIO
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, 11(1). NATURE PORTFOLIO
Funder: UKRI Future Leaders Fellowship (MR/S034498/1)
The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary fibroblasts leads to induction of
The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary fibroblasts leads to induction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e556be26fca830c44e59f68be49c49c
http://europepmc.org/articles/PMC7609715
http://europepmc.org/articles/PMC7609715
Autor:
Helen M. Rowe, Liane Fernandes, Lucia Conde, Greg J. Towers, Rebecca P. Sumner, Luisa Robbez-Masson, Maria T. Rodriguez-Plata, Thomas P. Peacock, Robert J. Gifford, Greta Mickute, Javier Herrero, Christopher H.C. Tie
Publikováno v:
EMBO Reports
EMBO reports
EMBO reports
Endogenous retroviruses (ERVs) have accumulated in vertebrate genomes and contribute to the complexity of gene regulation. KAP1 represses ERVs during development by its recruitment to their repetitive sequences through KRAB zinc‐finger proteins (KZ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0fc99f15f1d9ba36c25792e528579e
https://doi.org/10.15252/embr.201745000
https://doi.org/10.15252/embr.201745000
Publikováno v:
The Journal of Cell Biology
Cancer cells can rewire genetic and epigenetic regulatory networks to promote cell proliferation and evade the immune system. Using a focused CRISPR/Cas9 genetic screen, Cuellar et al. identify a novel role for the SETDB1 histone methyltransferase in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8cc32ecbbf13c61efd3df0a6a3078a
http://europepmc.org/articles/PMC5674904
http://europepmc.org/articles/PMC5674904
Autor:
Helen M. Rowe, Christopher H.C. Tie
Publikováno v:
Current opinion in virology. 25
Retrotransposons tune immune reactivity in differentiated cells because when they are transcribed, their nucleic acids can be viewed as non-self leading to innate immune sensing. Most retrotransposons, however, are subject to transcriptional regulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5912599f5546ca9c4e73647404b690e
https://pubmed.ncbi.nlm.nih.gov/28675832
https://pubmed.ncbi.nlm.nih.gov/28675832