Výsledky vyhledávání - "Christopher H. Woelk"

Akademický článek

Very early life microbiome and metabolome correlates with primary vaccination variability in children

Autor: Michael Shaffer, Katharine Best, Catherine Tang, Xue Liang, Steven Schulz, Eduardo Gonzalez, Cory H. White, Thomas P. Wyche, John Kang, Hendrik Wesseling, Begüm D. Topçuoğlu, Thomas Cairns, Theodore R. Sana, Robin M. Kaufhold, Julia M. Maritz, Christopher H. Woelk, Gokul Swaminathan, James E. Norton, Michael E. Pichichero

Publikováno v: mSystems, Vol 8, Iss 5 (2023)

ABSTRACT Despite multiple vaccine doses early in life, a substantial proportion of infants do not mount protective responses. In this study, we followed a cohort of children over the first 2 years of life, collecting microbiome and metabolome data lo

Externí odkaz: https://doaj.org/article/e7ffdf61323e4b3cbd3a8d0ab3ea26a1

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Akademický článek

Distinct subsets of neutrophils crosstalk with cytokines and metabolites in patients with sepsis

Autor: Upasana Parthasarathy, Yi Kuang, Gunjan Thakur, John D. Hogan, Thomas P. Wyche, James E. Norton, Jr., Jason R. Killough, Theodore R. Sana, Caroline Beakes, BaoJen Shyong, Rena N. Zhang, Dario A. Gutierrez, Michael Filbin, David C. Christiani, Alex G. Therien, Christopher H. Woelk, Cory H. White, Roberta Martinelli

Publikováno v: iScience, Vol 26, Iss 2, Pp 105948- (2023)

Summary: Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Despite continued efforts to understand the pathophysiology of sepsis, no effective therapies are currently available. While singular components of t

Externí odkaz: https://doaj.org/article/a7bebae0729f4859866504aea19e208c

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Akademický článek

Genomic programming of IRF4-expressing human Langerhans cells

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Langerhans cells (LC) can prime tolerogenic as well as immunogenic responses in the skin. Here the authors show, by transcriptomic, epigenetic and CRISPR editing analyses, that during LC migration and maturation the transcription factor IRF4 regulate

Externí odkaz: https://doaj.org/article/b437083920e842f086e6d17c31b3b048

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Akademický článek

Comprehensive plasma proteomic profiling reveals biomarkers for active tuberculosis

Autor: Diana J. Garay-Baquero, Cory H. White, Naomi F. Walker, Marc Tebruegge, Hannah F. Schiff, Cesar Ugarte-Gil, Stephen Morris-Jones, Ben G. Marshall, Antigoni Manousopoulou, John Adamson, Andres F. Vallejo, Magdalena K. Bielecka, Robert J. Wilkinson, Liku B. Tezera, Christopher H. Woelk, Spiros D. Garbis, Paul Elkington

Publikováno v: JCI Insight, Vol 5, Iss 18 (2020)

BACKGROUND Tuberculosis (TB) kills more people than any other infection, and new diagnostic tests to identify active cases are required. We aimed to discover and verify novel markers for TB in nondepleted plasma.METHODS We applied an optimized quanti

Externí odkaz: https://doaj.org/article/07efd161316b4f0ca6beceee411e2163

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Akademický článek

Vaccine Hyporesponse Induced by Individual Antibiotic Treatment in Mice and Non-Human Primates Is Diminished upon Recovery of the Gut Microbiome

Publikováno v: Vaccines, Vol 9, Iss 11, p 1340 (2021)

Emerging evidence demonstrates a connection between microbiome composition and suboptimal response to vaccines (vaccine hyporesponse). Harnessing the interaction between microbes and the immune system could provide novel therapeutic strategies for im

Externí odkaz: https://doaj.org/article/c57141bfb4b545c0b73222a00565d3e1

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Akademický článek

Transcriptional Modulation of Human Endogenous Retroviruses in Primary CD4+ T Cells Following Vorinostat Treatment

Autor: Cory H. White, Nadejda Beliakova-Bethell, Steven M. Lada, Michael S. Breen, Tara P. Hurst, Celsa A. Spina, Douglas D. Richman, John Frater, Gkikas Magiorkinis, Christopher H. Woelk

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

The greatest obstacle to a cure for HIV is the provirus that integrates into the genome of the infected cell and persists despite antiretroviral therapy. A “shock and kill” approach has been proposed as a strategy for an HIV cure whereby drugs an

Externí odkaz: https://doaj.org/article/267b0e62f7304abb9bedf9861844d643

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Figure S3 from Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma

Autor: Stephen M. Thirdborough, Gareth J. Thomas, Christopher H. Woelk, Jeongmin Woo, Oliver Wood, Jason Fleming, Veronika Jenei, Jana Stasakova, Elena L. Harden, Kate L. Perry, Christian H. Ottensmeier

Figure S3. Increased expression of the CD8+ T-cell signature has a prognostic value for overall survival. (A and B) Kaplan-Meier estimates of overall survival among patients grouped according to expression of genes with the strongest membership (kME{

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5952b780779b474c6f12702231a203
https://doi.org/10.1158/0008-5472.22411931

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Data from Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma

Antibodies that block T-cell–regulatory checkpoints have recently emerged as a transformative approach to cancer treatment. However, the clinical efficacy of checkpoint blockade depends upon inherent tumor immunogenicity, with variation in infiltra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a4224ea36aaf29a073eeb3b575e4788
https://doi.org/10.1158/0008-5472.c.6508331.v1

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