Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Christopher H. Choy"'
Salmonella actively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner
Autor:
Subothan Inpanathan, Erika Ospina-Escobar, Vanessa Cruz Li, Zainab Adamji, Tracy Lackraj, Youn Hee Cho, Natasha Porco, Christopher H. Choy, Joseph B. McPhee, Roberto J. Botelho
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT The transcription factor TFEB drives the expression of lysosomal, autophagic, and immune-responsive genes in response to LPS and phagocytosis. Interestingly, compounds that promote TFEB activity enhance bactericidal activity, while intracell
Externí odkaz:
https://doaj.org/article/1e3be32373c04a07bd765b1eb467c51c
Autor:
Issaka Yougbare, Adam McTague, Liwei He, Christopher H. Choy, Jin Su, Beata Gajewska, Ali Azizi
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The pertussis vaccination is highly recommended for infants, children, and pregnant women. Despite a high coverage of vaccination, pertussis continues to be of public health concern as a re-emerging infectious disease. The mechanism by which vaccine-
Externí odkaz:
https://doaj.org/article/f8fbd8e097d9453899ece3376f4653f7
Autor:
Ali Azizi, Liwei He, David Tulumello, Roberto J. Botelho, Beata Gajewska, Mauricio R. Terebiznik, Christopher H. Choy
Publikováno v:
Journal of Pharmaceutical Sciences. 111:672-679
Various vaccine quality attributes should be monitored to ensure consistency, potency, purity, and safety of vaccine products prior to lot release. Vaccine particle size and protein antigen aggregation are two important considerations for particle-ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26afef8a16ad34877a2969db3763002
https://doi.org/10.1016/j.xphs.2021.10.037
https://doi.org/10.1016/j.xphs.2021.10.037
Autor:
Subothan Inpanathan, Erika Ospina-Escobar, Youn Hee Cho, Natasha Porco, Christopher H. Choy, Joseph B. McPhee, Roberto J. Botelho
SummaryThe transcription factor TFEB promotes lysosomal and autophagic capacity in response to stresses like amino acid depletion. Additionally, TFEB drives expression of immune-responsive and immuno-protective genes in response to LPS, phagocytosis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0daecb9c34d46073abb3a46f2206f06f
https://doi.org/10.1101/2022.12.03.518968
https://doi.org/10.1101/2022.12.03.518968
Autor:
Jin Su, Liwei He, Issaka Yougbaré, Adam McTague, Christopher H Choy, Beata Gajewska, Ali Azizi
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
The pertussis vaccination is highly recommended for infants, children, and pregnant women. Despite a high coverage of vaccination, pertussis continues to be of public health concern as a re-emerging infectious disease. The mechanism by which vaccine-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e68748b2eb6b39fd1f89bfaa63c102a
https://pubmed.ncbi.nlm.nih.gov/33384692
https://pubmed.ncbi.nlm.nih.gov/33384692
Autor:
Richard M. Epand, Vincent So, Christopher H. Choy, Alexis Traynor-Kaplan, Jing Wu, Roberto J. Botelho, Mathieu Lemaire
BackgroundLoss-of-function mutations in diacylglycerol kinase epsilon (DGKE) cause a rare form of atypical hemolytic-uremic syndrome (aHUS) for which there is no treatment besides kidney transplantation. Highly expressed in kidney endothelial cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9735c9d57c6b64105b461d54da062ede
https://doi.org/10.1101/633867
https://doi.org/10.1101/633867
Autor:
Roberto J. Botelho, Matthew A. Gray, Zhen-Yi A. Ou, Golam T. Saffi, Simon C. Watkins, Christopher H. Choy, Roya M. Dayam, Callen T. Wallace, Rosa Puertollano, Guy M. Lenk
Publikováno v:
Journal of cell science. 131(10)
Lysosomes receive and degrade cargo from endocytosis, phagocytosis and autophagy. They also play an important role in sensing and instructing cells on their metabolic state. The lipid kinase PIKfyve generates phosphatidylinositol-3,5-bisphosphate to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a167aa7c7f965e55c244be2c6b7db1f8
https://pubmed.ncbi.nlm.nih.gov/29661845
https://pubmed.ncbi.nlm.nih.gov/29661845
Publikováno v:
BioEssays : news and reviews in molecular, cellular and developmental biology. 39(12)
Phosphoinositides (PtdInsPs) modulate a plethora of functions including signal transduction and membrane trafficking. PtdInsPs are thought to consist of seven interconvertible species that localize to a specific organelle, to which they recruit a set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f8875022712717776e698416e7a551
https://pubmed.ncbi.nlm.nih.gov/28977683
https://pubmed.ncbi.nlm.nih.gov/28977683
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1519
Phagocytosis is the actin-driven internalization of solid particles, utilized by phagocytic immune cells to sequester potentially infectious microorganisms. Aided by the innate and adaptive immune system, the activation of various phagocytic receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc1e736665794c17afba419c402699a0
https://pubmed.ncbi.nlm.nih.gov/27815872
https://pubmed.ncbi.nlm.nih.gov/27815872
Publikováno v:
Methods in Molecular Biology ISBN: 9781493965793
Phagocytosis is the actin-driven internalization of solid particles, utilized by phagocytic immune cells to sequester potentially infectious microorganisms. Aided by the innate and adaptive immune system, the activation of various phagocytic receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90031799234c414266df26d8abcc20ba
https://doi.org/10.1007/978-1-4939-6581-6_4
https://doi.org/10.1007/978-1-4939-6581-6_4