Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Christopher H Chen"'
Publikováno v:
eLife, Vol 13 (2024)
Purkinje cell (PC) synapses onto cerebellar nuclei (CbN) neurons allow signals from the cerebellar cortex to influence the rest of the brain. PCs are inhibitory neurons that spontaneously fire at high rates, and many PC inputs are thought to converge
Externí odkaz:
https://doaj.org/article/acf28932fe734e6abab14a3836b58c47
Autor:
Skyler L Jackman, Christopher H Chen, Heather L Offermann, Iain R Drew, Bailey M Harrison, Anna M Bowman, Katelyn M Flick, Isabella Flaquer, Wade G Regehr
Publikováno v:
eLife, Vol 9 (2020)
Although the cerebellum is traditionally associated with balance and motor function, it also plays wider roles in affective and cognitive behaviors. Evidence suggests that the cerebellar vermis may regulate aggressive behavior, though the cerebellar
Externí odkaz:
https://doaj.org/article/8f2ce728929d46918f77b3d691d75aaa
Autor:
Skyler L. Jackman, Christopher H. Chen, Selmaan N. Chettih, Shay Q. Neufeld, Iain R. Drew, Chimuanya K. Agba, Isabella Flaquer, Alexis N. Stefano, Thomas J. Kennedy, Justine E. Belinsky, Keiramarie Roberston, Celia C. Beron, Bernardo L. Sabatini, Christopher D. Harvey, Wade G. Regehr
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3351-3361 (2018)
Summary: Optical methods of interrogating neural circuits have emerged as powerful tools for understanding how the brain drives behaviors. Optogenetic proteins are widely used to control neuronal activity, while genetically encoded fluorescent report
Externí odkaz:
https://doaj.org/article/e13ca224def64c05abf9118f1cf56701
Publikováno v:
J Neurosci
Purkinje cells (PCs) are spontaneously active neurons of the cerebellar cortex that inhibit glutamatergic projection neurons within the deep cerebellar nuclei (DCN) that provide the primary cerebellar output. Brief reductions of PC firing rapidly inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6a88712061bf04227969cda5a56d34
https://doi.org/10.1523/jneurosci.1869-21.2022
https://doi.org/10.1523/jneurosci.1869-21.2022
Publikováno v:
bioRxiv
Purkinje cell (PC) synapses onto cerebellar nuclei (CbN) neurons convey signals from the cerebellar cortex to the rest of the brain. PCs are inhibitory neurons that spontaneously fire at high rates, and many uniform sized PC inputs are thought to con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e5e270c04aeeb9b190e2478ad44d49
https://europepmc.org/articles/PMC10245953/
https://europepmc.org/articles/PMC10245953/
Autor:
Joon-Hyuk Lee, Mehak M. Khan, Amanda P. Stark, Soobin Seo, Aliya Norton, Zhiyi Yao, Christopher H. Chen, Wade G. Regehr
Publikováno v:
Cell Rep
Within the cerebellar cortex, mossy fibers (MFs) excite granule cells (GCs) that excite Purkinje cells (PCs), which provide outputs to the deep cerebellar nuclei (DCNs). It is well established that PC disruption produces motor deficits such as ataxia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c96983165437602b703c04cbbd3beda
https://doi.org/10.1016/j.celrep.2023.112429
https://doi.org/10.1016/j.celrep.2023.112429
Publikováno v:
Nature neuroscience
Climbing fibers from the inferior olive make strong excitatory synapses onto cerebellar Purkinje cell (PC) dendrites and trigger distinctive responses known as complex spikes. We found that, in awake mice, a complex spike in one PC suppressed convent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a23bff84cd253dd6126d100f148fa81
http://europepmc.org/articles/PMC7606706
http://europepmc.org/articles/PMC7606706
Autor:
Christopher H. Chen, Leannah N. Newman, Amanda P. Stark, Katherine E. Bond, Dawei Zhang, Stefano Nardone, Charles R. Vanderburg, Naeem M. Nadaf, Zhiyi Yao, Kefiloe Mutume, Isabella Flaquer, Bradford B. Lowell, Evan Z. Macosko, Wade G. Regehr
In addition to its well-known contributions to motor function, the cerebellum is involved in emotional regulation, anxiety, and affect1-4. We found that suppressing the firing of cerebellar Purkinje cells (PCs) rapidly excites forebrain areas that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b02c59b5ddf34c974a98e3236072648e
https://doi.org/10.1101/2021.09.21.461236
https://doi.org/10.1101/2021.09.21.461236
Purkinje cells (PCs) are spontaneously active neurons of the cerebellar cortex that inhibit glutamatergic projection neurons within the deep cerebellar nuclei (DCN) that in turn provide the primary cerebellar output. Brief reductions in PC firing rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96408fefffc8484b8f759ef14ee139cb
https://doi.org/10.1101/2021.08.10.455865
https://doi.org/10.1101/2021.08.10.455865
Autor:
Carlton G Willson, Christopher H. Chen, Ryan Deschner, Christopher W. Bielawski, Wontae Joo, Jonathan P. Moerdyk
Publikováno v:
Journal of Polymer Science Part A: Polymer Chemistry. 57:1791-1795
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0c25a05ff321355ab525b2560ac815c
https://doi.org/10.1002/pola.29449
https://doi.org/10.1002/pola.29449