Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Christopher H Bohrer"'
Autor:
Christopher H Bohrer, Daniel R Larson
Publikováno v:
eLife, Vol 12 (2023)
The role of the spatial organization of chromosomes in directing transcription remains an outstanding question in gene regulation. Here, we analyze two recent single-cell imaging methodologies applied across hundreds of genes to systematically analyz
Externí odkaz:
https://doaj.org/article/36fbe1cc86164b80abee9c3bc313d74e
Autor:
Brian Tenner, Michael Getz, Brian Ross, Donya Ohadi, Christopher H Bohrer, Eric Greenwald, Sohum Mehta, Jie Xiao, Padmini Rangamani, Jin Zhang
Publikováno v:
eLife, Vol 9 (2020)
Signaling networks are spatiotemporally organized to sense diverse inputs, process information, and carry out specific cellular tasks. In β cells, Ca2+, cyclic adenosine monophosphate (cAMP), and Protein Kinase A (PKA) exist in an oscillatory circui
Externí odkaz:
https://doaj.org/article/08e44b5ad3c04a598dfea6414b917d7e
Publikováno v:
Cold Spring Harbor perspectives in biology. 13(10)
Mammalian genomes have distinct levels of spatial organization and structure that have been hypothesized to play important roles in transcription regulation. Although much has been learned about these architectural features with ensemble techniques,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56ca97c6b587f3a31915248d4d4a487
https://pubmed.ncbi.nlm.nih.gov/33903158
https://pubmed.ncbi.nlm.nih.gov/33903158
Autor:
Xin Chen, Jin Zhang, Christopher H. Bohrer, Jie Xiao, Matthew Wooten, Brian Tenner, Elijah Roberts, Brian Ross, Xiaoli Weng, Shreyasi Thakur, Xinxing Yang, Melike Lakadamyali, Ryan McQuillen
Publikováno v:
Nat Methods
Single-molecule localization microscopy (SMLM) relies on the blinking behavior of a fluorophore, which is the stochastic switching between fluorescent and dark states. Blinking creates multiple localizations belonging to the same fluorophore, confoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84eaf1e2c14e778519684b66c62cbc67
https://doi.org/10.1038/s41592-021-01154-y
https://doi.org/10.1038/s41592-021-01154-y
Most bacteria lack membrane-enclosed organelles to compartmentalize cellular processes. In lieu of physical compartments, bacterial proteins are often recruited to macromolecular scaffolds at specific subcellular locations to carry out their function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef8d49d535748904bb7e361dd413e5d3
https://doi.org/10.1101/2022.05.01.490209
https://doi.org/10.1101/2022.05.01.490209
Autor:
Yuncong Geng, Christopher H. Bohrer, Nicolás Yehya, Hunter Hendrix, Lior Shachaf, Jian Liu, Jie Xiao, Elijah Roberts
In Escherichia coli, translocation of RNA polymerase (RNAP) during transcription introduces supercoiling to DNA, which influences the initiation and elongation behaviors of RNAP. To quantify the role of supercoiling in transcription regulation, we de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5a7f656465e47a0d7fc40914108ef3
https://doi.org/10.1101/2021.12.29.474406
https://doi.org/10.1101/2021.12.29.474406
Autor:
Kelsey Bettridge, Cedric Cagliero, Jie Xiao, Ding Jun Jin, Christopher H. Bohrer, Xiaoli Weng, Arvin Cesar Lagda
Publikováno v:
Proceedings of the National Academy of Sciences. 116:20115-20123
Recent studies have shown that RNA polymerase (RNAP) is organized into distinct clusters in Escherichia coli and Bacillus subtilis cells. Spatially organized molecular components in prokaryotic systems imply compartmentalization without the use of me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b60e23c2816b87ecbb8a98e3132f716
https://doi.org/10.1073/pnas.1903968116
https://doi.org/10.1073/pnas.1903968116
Autor:
Melike Lakadamyali, Jie Xiao, Arian Arab, Melina Theoni Gyparaki, Christopher H. Bohrer, Adriana N. Santiago-Ruiz, Elena M. Sorokina
Publikováno v:
Proc Natl Acad Sci U S A
Tau is a microtubule-associated protein, which promotes neuronal microtubule assembly and stability. Accumulation of tau into insoluble aggregates known as neurofibrillary tangles (NFTs) is a pathological hallmark of several neurodegenerative disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67bcb0102a665c9747b16d0e99b7b7a0
https://pubmed.ncbi.nlm.nih.gov/33952699
https://pubmed.ncbi.nlm.nih.gov/33952699
Author response: Spatially compartmentalized phase regulation of a Ca2+-cAMP-PKA oscillatory circuit
Autor:
Michael Getz, Jin Zhang, Jie Xiao, Donya Ohadi, Brian Tenner, Christopher H. Bohrer, Brian Ross, Padmini Rangamani, Sohum Mehta, Eric Greenwald
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bf3b0722203a9893bc62d2082d6aabe
https://doi.org/10.7554/elife.55013.sa2
https://doi.org/10.7554/elife.55013.sa2