Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christopher H, Hill"'
Publikováno v:
Plant Ecology. 223:41-52
In boreal species, populations at a southern range edge are at risk of being extirpated due to rising temperatures from climate change and potentially from demographic factors that affect small populations. The ability to track climate through phenol
Publikováno v:
Analog Integrated Circuits and Signal Processing. 34:247-255
A large dynamic range high frequency fully differential CMOS transconductance amplifier is introduced. It is based on the linear transconductance element proposed in l8r combined with the common-mode feedback circuit in l9r. The original transconduct
Autor:
Sandra E. Wilkinson, Janet L. Smith, Peter D. Davis, Harris William, David R. Vesey, John S. Nixon, Geoffrey Lawton, Christopher H. Hill, Trevor J. Hallam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1303-1308
A pharmacophore model for the localisation of the cationic binding site of bisindolylmaleimide PKC inhibitors is described. This model has been used to guide selection of further conformationally restricted tertiary amine analogues, culminating in th
Publikováno v:
Current opinion in drug discoverydevelopment. 7(5)
Autor:
David R. Vesey, Christopher H. Hill, Rino A. Bit, Christopher J. Hobbs, Eric A. Kitas, Brad S. Sherborne, David Pole, Fiona Wilson, Antonin Kroehn, Glyn Williams, Bill Harris, Ian R. Kilford, David Banner, Neera Borkakoti, D.Lee Walmsley, David Whittaker, Paul Rugman, Andrew Cansfield, Ian Edward David Smith, Allan Surgenor, Katherine L. Hilyard, Peter Lovell
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(10)
Starting from the tetrapeptide Ac-pYEEI-NHMe and using a structure-based approach, we have designed and synthesised a peptidomimetic ligand for p56(lck) SH2 domain containing a conformationally restricted replacement for the two glutamate residues. W
Autor:
Rino A. Bit, Peter D. Davis, Lucy H. Elliott, William Harris, Christopher H. Hill, Elizabeth Keech, Hari Kumar, Geoffrey Lawton, Anna Maw, John S. Nixon, David R. Vesey, Julie Wadsworth, Sandra E. Wilkinson
Publikováno v:
Journal of medicinal chemistry. 36(1)
The protein kinase inhibitor staurosporine has been used to design a series of selective bisindolylmaleimide inhibitors of protein kinase C (PKC). Guided by molecular graphics, conformational restriction of the cationic side chain has led to ATP comp
Publikováno v:
ChemInform. 18
Publikováno v:
ChemInform. 18
The oxidation of a series of steroids by the Gif system gives, almost without exception, the 20-ketone as major isolated product. The side-chain cleavage is made more selective by modification of rings A or B. The oxidation of oleana-1,12-diene-3,11-
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1805
The oxidation by the Gif system of the two dienones (3) and (15) which lack a 25-H still affords minor amounts of the 20-ketone (12). This indicates that there are two mechanisms for the degradation of the cholesterol side-chain, the major route as p
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1797
The oxidation of a series of steroids by the Gif system gives, almost without exception, the 20-ketone as major isolated product. The side-chain cleavage is made more selective by modification of rings A or B. The oxidation of oleana-1,12-diene-3,11-