Výsledky vyhledávání - "Christopher Geven"

Akademický článek

Adrecizumab, a non-neutralizing anti-adrenomedullin antibody, improves haemodynamics and attenuates myocardial oxidative stress in septic rats

Autor: Alice Blet, Benjamin Deniau, Christopher Geven, Malha Sadoune, Anaïs Caillard, Paul-Robert Kounde, Evelyne Polidano, Peter Pickkers, Jane-Lise Samuel, Alexandre Mebazaa

Publikováno v: Intensive Care Medicine Experimental, Vol 7, Iss 1, Pp 1-13 (2019)

Abstract Background Sepsis still represents a major health issue, with persistent high morbidity and mortality rates. Cardiovascular dysfunction occurs frequently during sepsis. Adrenomedullin has been identified as a key mediator in vascular tone re

Externí odkaz: https://doaj.org/article/f989ddc660074b0c9d38b3fea6b10944

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Akademický článek

Adrenomedullin and Adrenomedullin-Targeted Therapy As Treatment Strategies Relevant for Sepsis

Autor: Christopher Geven, Matthijs Kox, Peter Pickkers

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Sepsis remains a major medical challenge, for which, apart from improvements in supportive care, treatment has not relevantly changed over the last few decades. Vasodilation and vascular leakage play a pivotal role in the development of septic shock,

Externí odkaz: https://doaj.org/article/158e3f4fd70c4cb6bb0baa47f9c46220

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Akademický článek

The mechanism of action of the adrenomedullin-binding antibody adrecizumab

Autor: Christopher Geven, Peter Pickkers

Publikováno v: Critical Care, Vol 22, Iss 1, Pp 1-2 (2018)

Externí odkaz: https://doaj.org/article/e88f3936456742678e5ea46182873877

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Experimental human endotoxemia as a model of systemic inflammation

Autor: Guus P. Leijte, Christopher Geven, Dirk van Lier, Peter Pickkers

Publikováno v: Biochimie, 159, 99-106
Biochimie, 159, pp. 99-106

Item does not contain fulltext Systemic inflammation plays a pivotal role in a multitude of conditions, including sepsis, trauma, major surgery and burns. However, comprehensive analysis of the pathophysiology underlying this systemic inflammatory re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7baf10b53ebd8fe40efbb73ce932aada
https://doi.org/10.1016/j.biochi.2018.06.014

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Adrenomedullin in heart failure: pathophysiology and therapeutic application

Autor: Hans-Dirk Düngen, Christopher Geven, Andreas Bergmann, Alexandre Mebazaa, Marco Metra, Javed Butler, Peter Pickkers, Daan Kremer, Jozine M. ter Maaten, Joachim Struck, Adriaan A. Voors

Publikováno v: European Journal of Heart Failure, 21, 2, pp. 163-171
European Journal of Heart Failure
European Journal of Heart Failure, 21, 163-171

Contains fulltext : 206328.pdf (Publisher’s version ) (Open Access) Adrenomedullin (ADM) is a peptide hormone first discovered in 1993 in pheochromocytoma. It is synthesized by endothelial and vascular smooth muscle cells and diffuses freely betwee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd2b4f451c9f08b131b8f7a538d1820
https://doi.org/10.1002/ejhf.1366

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Letter to the Editor: Vitamin D deficiency in COVID-19: Mixing up cause and consequence

Autor: Christopher Geven, Matthijs Kox, Jody van den Ouweland, Joost Smolders, Peter Pickkers

Publikováno v: Metabolism
Metabolism: Clinical and Experimental, 115:154434. W.B. Saunders
Metabolism-Clinical and Experimental, 115

Contains fulltext : 232770.pdf (Publisher’s version ) (Closed access)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f39f54ed66441e42f568c310e5aa87
https://pubmed.ncbi.nlm.nih.gov/33301775

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Safety, tolerability and pharmacokinetics/pharmacodynamics of the adrenomedullin antibody adrecizumab in a first-in-human study and during experimental human endotoxaemia in healthy subjects

Autor: Roel V Peelen, Christopher Geven, Bas ten Elzen, Matthijs Kox, Alice Blet, Peter Pickkers, Dirk van Lier, Alexandre Mebazaa

Publikováno v: British Journal of Clinical Pharmacology. 84:2129-2141

Aims Adrenomedullin (ADM) is an important regulator of endothelial barrier function and vascular tone, and may represent a novel treatment target in sepsis. The non-neutralizing ADM antibody adrecizumab has shown promising results in preclinical seps

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::893b9f9718a9eb9ca5010a815297ef3d
https://doi.org/10.1111/bcp.13655

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Bioactive Adrenomedullin, Organ Support Therapies, and Survival in the Critically Ill: Results from the French and European Outcome Registry in ICU Study

Autor: Benjamin Deniau, Andreas Bergmann, Pierre-François Laterre, Alexandre Mebazaa, Alice Blet, Xavier Monnet, Marie-Céline Fournier, Oliver Hartmann, Léa Lemasle, Christopher Geven, Michael Darmon, Alexa Hollinger, Etienne Gayat, Isabelle Rennuit, Ményssa Cherifa, Joachim Struck

Publikováno v: Critical care medicine, Vol. 48, no.1, p. 49-55 (2020)
Critical Care Medicine, 48, 1, pp. 49-55
Critical Care Medicine, 48, 49-55

OBJECTIVES: Adrenomedullin has vascular properties and elevated plasma adrenomedullin levels were detected in sepsis. We assessed, in septic and nonseptic ICU patients, the relation between circulating adrenomedullin, the need for organ support and m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c00202565062438c5fb707d461f68c
https://pubmed.ncbi.nlm.nih.gov/31625979

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