Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Christopher Gajda"'
Autor:
Larry J. Markoski, Stephen J. Gracheck, Carolyn Nouhan, Peter J. Tummino, Steven VanderRoest, James Saunders, J. V. N. Vara Prasad, Krishna R. Iyer, Christopher Gajda, Fred E. Boyer, Donna Ferguson, Elizabeth A. Lunney, John M. Domagala, Bradley Dean Tait, Michael Sinz, Donald Hupe, Tod P. Holler, Susan Elizabeth Hagen, Edmund L. Ellsworth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2217-2222
Dihydropyran-2-one possessing a sulfamate moiety at the 4-position of the thiophenyl ring were designed to reach S 3 ′ pocket of the HIV protease. Synthetic routes for the preparation of thiotosylates possessing 3-(2- t -butyl-5-methyl-4-sulfamate)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dfe7dbbe05f1f8f725ff6437c2d163a
https://doi.org/10.1016/s0960-894x(99)00360-1
https://doi.org/10.1016/s0960-894x(99)00360-1
Autor:
Elizabeth A. Lunney, Frederick E. Boyer, J. V. N. Vara Prasad, Stephen J. Gracheck, Carolyn Nouhan, Edmund L. Ellsworth, Bradley Dean Tait, Donna Ferguson, Susan Elizabeth Hagen, Steven VanderRoest, Larry J. Markoski, James Saunders, Harriet W. Hamilton, B. A. Steinbaugh, Peter J. Tummino, John M. Domagala, Donald Hupe, Christopher Gajda
Publikováno v:
Journal of Medicinal Chemistry. 40:3707-3711
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42deb683af35eb770b675bfb72a20b2e
https://doi.org/10.1021/jm970522y
https://doi.org/10.1021/jm970522y
Autor:
John W. Erickson, Donald Hupe, Eric T. Baldwin, J. R. Rubin, and Sergei V. Gulnik, Christine Humblet, Susan Elizabeth Hagen, Christopher Gajda, Harriet W. Hamilton, Carolyn Nouhan, Beishan Liu, J. V. N. Vara Prasad, Neil Graham, Edmund L. Ellsworth, Peter J. Tummino, John M. Domagala, Alexander Pavlovsky, Donna Ferguson, Elizabeth A. Lunney, T. N. Bhat, Bradley Dean Tait, Stephen J. Gracheck
Publikováno v:
Journal of Medicinal Chemistry. 40:3781-3792
The 4-hydroxy-5,6-dihydropyrone template was utilized as a flexible scaffolding from which to build potent active site inhibitors of HIV protease. Dihydropyrone 1c (5,6-dihydro-4-hydroxy-6-phenyl-3-[(2-phenylethyl)thio]-2H-pyran-2-one) was modeled in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7aad4e0c13b30c8749077fa2809ed3
https://doi.org/10.1021/jm970615f
https://doi.org/10.1021/jm970615f
Autor:
Christopher Gajda, Bradley Dean Tait, Peter J. Tummino, Harriet W. Hamilton, Susan Elizabeth Hagen, Alexander Pavlovsky, Donna Ferguson, Elizabeth A. Lunney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:719-724
Publications from our laboratories have recently described a series of 3-thioaryl substituted-4-hydroxy-pyrones1 as HIV protease inhibitors. The current work examines the analogous 5,6-dihydro-2H-pyran-2-ones with 6,6-substitutions focusing on the us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::287f79ce140265a0a7c03fb779adfe60
https://doi.org/10.1016/0960-894x(96)00099-6
https://doi.org/10.1016/0960-894x(96)00099-6
Autor:
Elizabeth A. Lunney, Donna Ferguson, Edmund L. Ellsworth, Bradley Dean Tait, Donald Hupe, Christopher Gajda, John M. Domagala, Peter J. Tummino
Publikováno v:
Journal of Molecular Recognition. 9:139-142
New templates were designed and prepared which straddle the active site of HIV-1 protease. These templates were designed to be "flexible scaffolds' upon which substituents could be appended to fill the pockets of HIV protease. The new templates prepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d281638c28cd1eb87b9535e9b0eda4c5
https://doi.org/10.1002/(sici)1099-1352(199603)9:2<139::aid-jmr249>3.0.co
https://doi.org/10.1002/(sici)1099-1352(199603)9:2<139::aid-jmr249>3.0.co
Autor:
Mark Lautens, Christopher Gajda
Publikováno v:
Tetrahedron Letters. 34:4591-4594
Oxabicyclo[3.2.1]octenes have been found to undergo a tandem ring-opening-elimination reaction when treated with an organolithium reagent in DME.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::786de5f28f8ab8d1ee5d1ba6680d3f60
https://doi.org/10.1016/s0040-4039(00)60632-9
https://doi.org/10.1016/s0040-4039(00)60632-9
Autor:
Christopher Gajda, James R. Green
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1abe81c42530e04d252724549b3a66c7
https://doi.org/10.1002/chin.199342220
https://doi.org/10.1002/chin.199342220
Publikováno v:
ChemInform. 24
Oxabicyclo[3.2.1]octenes have been found to undergo enantioselective ring opening in the presence of a catalytic quantity of the chiral amine sparteine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50ca4fdfe82e9b6fd10d7af9d2751d35
https://doi.org/10.1002/chin.199344067
https://doi.org/10.1002/chin.199344067
Autor:
Christopher Gajda, Mark Lautens
Publikováno v:
ChemInform. 24
Oxabicyclo[3.2.1]octenes have been found to undergo a tandem ring-opening-elimination reaction when treated with an organolithium reagent in DME.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f997c94e01e9d875313b470341fe4139
https://doi.org/10.1002/chin.199341154
https://doi.org/10.1002/chin.199341154
Autor:
Susan Elizabeth Hagen, Bradley Dean Tait, Elizabeth A. Lunney, Christopher Gajda, Alexander Pavlovsky, Donna Ferguson, Harriet W. Hamilton, Peter J. Tummino
Publikováno v:
ChemInform. 27
Publications from our laboratories have recently described a series of 3-thioaryl substituted-4-hydroxy-pyrones1 as HIV protease inhibitors. The current work examines the analogous 5,6-dihydro-2H-pyran-2-ones with 6,6-substitutions focusing on the us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::851913e4a583a0e36d06f58c246376e9
https://doi.org/10.1002/chin.199629152
https://doi.org/10.1002/chin.199629152