Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christopher G. Thomson"'
Autor:
Sheng Wang, Sebastian O. Klein, Sylvia Urban, Maximilian Staudt, Nicolas P. F. Barthes, Dominica Willmann, Johannes Bacher, Manuela Sum, Helena Bauer, Ling Peng, Georg A. Rennar, Christian Gratzke, Katrin M. Schüle, Lin Zhang, Oliver Einsle, Holger Greschik, Calum MacLeod, Christopher G. Thomson, Manfred Jung, Eric Metzger, Roland Schüle
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Inhibition of epigenetic regulators by small molecules is an attractive strategy for cancer treatment. Recently, we characterised the role of lysine methyltransferase 9 (KMT9) in prostate, lung, and colon cancer. Our observation that the enz
Externí odkaz:
https://doaj.org/article/dd0315952e94463cb2a9a88ac996f944
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1495-1549 (2020)
The synergy between photocatalysis and continuous flow chemical reactors has shifted the paradigms of photochemistry, opening new avenues of research with safer and scalable processes that can be readily implemented in academia and industry. Current
Externí odkaz:
https://doaj.org/article/3705fd6039bc4ec68d0b8486b40aac97
Autor:
Emmanouil Broumidis, Christopher G. Thomson, Brendan Gallagher, Lia Sotorríos, Kenneth G. McKendrick, Stuart A. Macgregor, Martin J. Paterson, Janet E. Lovett, Gareth O. Lloyd, Georgina M. Rosair, Andreas S. Kalogirou, Panayiotis A. Koutentis, Filipe Vilela
Thiadiazoles are a privileged motif in medicinal chemistry, however selective mono-oxidation of the endocyclic sulfur, without over oxidation, is challenging. Herein, we report the quantitative conversion of 1,2,6-thiadiazines to 1,2,5-thiadiazole 1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4d0446729b7b2fa77e21d3cee94453d
https://doi.org/10.26434/chemrxiv-2022-sqj97
https://doi.org/10.26434/chemrxiv-2022-sqj97
Publikováno v:
Chemical Science
Tetrazoles play a prominent role in medicinal chemistry due to their role as carboxylate bioisosteres but have largely been overlooked as C–H functionalisation substrates. We herein report the development of a high-yielding and general procedure fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83330de405c75bb4da08be644572fbf
https://doi.org/10.1039/d1sc04176b
https://doi.org/10.1039/d1sc04176b
Publikováno v:
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1495-1549 (2020)
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1495-1549 (2020)
The synergy between photocatalysis and continuous flow chemical reactors has shifted the paradigms of photochemistry, opening new avenues of research with safer and scalable processes that can be readily implemented in academia and industry. Current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a449796021b37877cefbcf7fd81a4409
http://europepmc.org/articles/PMC7323633
http://europepmc.org/articles/PMC7323633
Autor:
Callum M. S. Jones, Filipe Vilela, Georgina M. Rosair, Ai-Lan Lee, David Ellis, Christopher G. Thomson, Jose Marques-Hueso
Publikováno v:
Journal of Flow Chemistry. 10:327-345
Commercial polystyrene Merrifield-type resins have been post-synthetically functionalised with BODIPY photosensitisers via a novel aryl ester linking strategy in continuous-flow. A unique synthetic advantage of post-synthetically modifying heterogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d5c2ddbc831ec9c1e15013b331074d9
https://doi.org/10.1007/s41981-019-00067-4
https://doi.org/10.1007/s41981-019-00067-4
Autor:
Christopher R. Coxon, Colin Banks, Mark T. Allen, Graeme Barker, Filipe Vilela, Ai-Lan Lee, Christopher G. Thomson
Publikováno v:
The Journal of organic chemistry. 86(20)
Recent advancements in in-line extraction and purification technology have enabled complex multistep synthesis in continuous flow reactor systems. However, for the large scope of chemical reactions that yield mixtures of products or residual starting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be55735cfcf43ed418de83328403fe1e
https://pubmed.ncbi.nlm.nih.gov/34270260
https://pubmed.ncbi.nlm.nih.gov/34270260
Autor:
Mary C. Jones, Adilet Zhakeyev, Jin Xuan, Filipe Vilela, John M. Tobin, Huizhi Wang, Christopher G. Thomson
Publikováno v:
Additive Manufacturing. 38:101828
A 2,1,3-benzothiadiazole-based photosensitiser has been successfully incorporated into a commercially available 3D printing resin and utilised to fabricate inherently photocatalytic flow reactor components. The freedom of design provided by additive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::484ca33fe4f9b5fb0cb5230b878521c2
https://doi.org/10.1016/j.addma.2020.101828
https://doi.org/10.1016/j.addma.2020.101828