Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Christopher G. Tate"'
Autor:
Anastasiia Gusach, Yang Lee, Armin Nikpour Khoshgrudi, Elizaveta Mukhaleva, Ning Ma, Eline J. Koers, Qingchao Chen, Patricia C. Edwards, Fanglu Huang, Jonathan Kim, Filippo Mancia, Dmitry B. Veprintsev, Nagarajan Vaidehi, Simone N. Weyand, Christopher G. Tate
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract There are two main families of G protein-coupled receptors that detect odours in humans, the odorant receptors (ORs) and the trace amine-associated receptors (TAARs). Their amino acid sequences are distinct, with the TAARs being most similar
Externí odkaz:
https://doaj.org/article/652fff5f256d4ddc952071804619e0c2
Autor:
Andras S. Solt, Mark J. Bostock, Binesh Shrestha, Prashant Kumar, Tony Warne, Christopher G. Tate, Daniel Nietlispach
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
β1-adrenergic receptors are expressed in cardiac tissue and stimulated by the sympathetic nervous system. Here, the authors use NMR spectroscopy to unravel the conformational diversity upon β1-adrenergic receptor activation and provide structural i
Externí odkaz:
https://doaj.org/article/4e7fd3c6652e45599736267dcb9722e4
Publikováno v:
Trends in Pharmacological Sciences. 44:162-174
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aabc8e4def3a985a65470cd00c0d46f
https://doi.org/10.1016/j.tips.2022.12.002
https://doi.org/10.1016/j.tips.2022.12.002
Publikováno v:
Nature. 603:743-748
The fungal class D1 G-protein-coupled receptor (GPCR) Ste2 has a different arrangement of transmembrane helices compared with mammalian GPCRs and a distinct mode of coupling to the heterotrimeric G protein Gpa1–Ste2–Ste181. In addition, Ste2 lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a00b52c83b6da6a0f3f5846c3d80fe
https://doi.org/10.1038/s41586-022-04498-3
https://doi.org/10.1038/s41586-022-04498-3
Publikováno v:
eLife, Vol 7 (2018)
The adenosine A2A receptor (A2AR) is a prototypical G protein-coupled receptor (GPCR) that couples to the heterotrimeric G protein GS. Here, we determine the structure by electron cryo-microscopy (cryo-EM) of A2AR at pH 7.5 bound to the small molecul
Externí odkaz:
https://doaj.org/article/8d680e6ec950444e8faa3bf12c4f8e4a
Publikováno v:
Journal of Applied Remote Sensing. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6e54f4674065c8c1f4453fd60006a11
https://doi.org/10.1117/1.jrs.16.034532
https://doi.org/10.1117/1.jrs.16.034532
Publikováno v:
Current Opinion in Structural Biology. 80:102574
Over the past three years (2020–2022) more structures of GPCRs have been determined than in the previous twenty years (2000–2019), primarily of GPCR complexes that are large enough for structure determination by single-particle cryo-EM. This revi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c449f96f4d475a89cfb51ab60b42cd
https://doi.org/10.1016/j.sbi.2023.102574
https://doi.org/10.1016/j.sbi.2023.102574
Autor:
Rony Nehmé, Byron Carpenter, Ankita Singhal, Annette Strege, Patricia C Edwards, Courtney F White, Haijuan Du, Reinhard Grisshammer, Christopher G Tate
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175642 (2017)
Mini-G proteins are the engineered GTPase domains of Gα subunits. They couple to GPCRs and recapitulate the increase in agonist affinity observed upon coupling of a native heterotrimeric G protein. Given the small size and stability of mini-G protei
Externí odkaz:
https://doaj.org/article/a5fac57f40484242b84cb93eef39e9ee
Autor:
Lukas, Helfinger, Christopher G, Tate
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2507
The thyroid-stimulating hormone receptor (TSHR) is a Class A G protein-coupled receptor (GPCR) that mediates signalling through the hypothalamic-pituitary-thyroid axis. Inappropriate activation of TSHR by autoantibodies or mutations, results in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::480975dbe39838fb33d492a0024f1b3c
https://pubmed.ncbi.nlm.nih.gov/35773589
https://pubmed.ncbi.nlm.nih.gov/35773589
Autor:
David E. Gloriam, Nagarajan Vaidehi, Yang Lee, Gáspár Pándy-Szekeres, Ning Ma, Christopher G. Tate, Vaithish Velazhahan, Albert J. Kooistra
Publikováno v:
Nature
G-protein-coupled receptors (GPCRs) are divided phylogenetically into six classes1,2, denoted A to F. More than 370 structures of vertebrate GPCRs (belonging to classes A, B, C and F) have been determined, leading to a substantial understanding of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec478de189e8db136a25b59da5bbaa59
https://doi.org/10.1038/s41586-020-2994-1
https://doi.org/10.1038/s41586-020-2994-1