Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Christopher G. Skipwith"'
Publikováno v:
Sensors, Vol 15, Iss 8, Pp 19912-19924 (2015)
Dopamine is widely innervated throughout the brain and critical for many cognitive and motor functions. Imbalances or loss in dopamine transmission underlie various psychiatric disorders and degenerative diseases. Research involving cellular studies
Externí odkaz:
https://doaj.org/article/54b2e9ffbaf74be5911d435b84f836b9
Autor:
X. Long Zheng, Haifeng M. Wu, Dezhi Shang, Erica Falls, Christopher G. Skipwith, Spero R. Cataland, Charles L. Bennett, Hau C. Kwaan
Publikováno v:
Haematologica, Vol 95, Iss 9 (2010)
Background Type G immunoglobulins against ADAMTS13 are the primary cause of acquired (idiopathic) thrombotic thrombocytopenic purpura. However, the domains of ADAMTS13 which the type G anti-ADAMT13 immunoglobulins target have not been investigated in
Externí odkaz:
https://doaj.org/article/73de22e33cf847be80ef90d8902c2dd2
Autor:
Christopher G. Skipwith, Polina Anikeeva, Vladimir Bulovic, Wendi Chang, Alexander W. Senko, Heather A. Clark, Timothy T. Ruckh
Publikováno v:
ACS nano. 10(4)
The tools for optically imaging cellular potassium concentrations in real-time are currently limited to a small set of molecular indicator dyes. Quantum dot-based nanosensors are more photostable and tunable than organic indicators, but previous desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323d39f18c05c0505c8cec23b2130767
https://pubmed.ncbi.nlm.nih.gov/27089024
https://pubmed.ncbi.nlm.nih.gov/27089024
Publikováno v:
Journal of Biological Chemistry. 285:28596-28603
Previous studies have demonstrated that factor VIII (FVIII) or platelets alone increase cleavage of von Willebrand factor (VWF) by ADAMTS13 under mechanically induced shear stresses. We show in this study that the combination of FVIII and platelets a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5822b9628b79c389c9ed91d975870cd
https://doi.org/10.1074/jbc.m110.131227
https://doi.org/10.1074/jbc.m110.131227
Autor:
Charles L. Bennett, Erica M. Falls, X. Long Zheng, Dezhi Shang, Christopher G. Skipwith, Spero R. Cataland, Hau C. Kwaan, Haifeng M. Wu
Publikováno v:
Haematologica. 95:1555-1562
Background Type G immunoglobulins against ADAMTS13 are the primary cause of acquired (idiopathic) thrombotic thrombocytopenic purpura. However, the domains of ADAMTS13 which the type G anti-ADAMT13 immunoglobulins target have not been investigated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ff5e978b3dbcf22264397f5ca25559
https://doi.org/10.3324/haematol.2009.019299
https://doi.org/10.3324/haematol.2009.019299
Autor:
Masayuki Endo, Sheng-Yu Jin, Wenjing Cao, Philip W. Zoltick, Nidal Muvarak, Christopher G. Skipwith, Alan W. Flake, Masami Niiya, Dezhi Shang, X. Long Zheng, David G. Motto
Publikováno v:
Molecular Therapy. 17(1):34-41
Deficiency of A Disintegrin And Metalloprotease with ThromboSpondin (ADAMTS13) results in thrombotic thrombocytopenic purpura (TTP). Plasma infusion or exchange is the only effective treatment to date. We show in this study that an administration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1035584c5837834dcd99da1773c7f7c2
Publikováno v:
Thrombosis and haemostasis. 110(1)
Compromised shear-dependent cleavage of type 2N von Willebrand factor variants by ADAMTS13 in the presence of factor VIII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76965302440032c98064666455a7274
https://pubmed.ncbi.nlm.nih.gov/23636243
https://pubmed.ncbi.nlm.nih.gov/23636243
Autor:
Sheng Yu Jin, X. Long Zheng, Lingjie Gong, Christopher G. Skipwith, Juan Xiao, Cui Jian, Hau C. Kwaan
Publikováno v:
Blood. 119(16)
Thrombotic thrombocytopenic purpura (TTP) is primarily caused by immunoglobulin G (IgG) autoantibodies against A Disintegrin And Metalloprotease with ThromboSpondin type 1 repeats, 13 (ADAMTS13). Nearly all adult idiopathic TTP patients harbor IgGs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cad549c7d60b245c6f63414ec4a4c10
https://pubmed.ncbi.nlm.nih.gov/22517874
https://pubmed.ncbi.nlm.nih.gov/22517874
Publikováno v:
Blood. 115(11)
Previous studies have shown that ADAMTS13 spacer domain is required for cleavage of von Willebrand factor (VWF). However, the exact amino acid residues within this domain critical for substrate recognition are not known. Epitope mapping of anti-ADAMT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f89f7a178a5c74289bb7aae6ca765e6
https://pubmed.ncbi.nlm.nih.gov/20075158
https://pubmed.ncbi.nlm.nih.gov/20075158
Von Willebrand factor (vWF) is synthesized in all vascular endothelial cells and megakaryocytes 1. The mature vWF is stored in the Weibel-Palade bodies of endothelial cells and the α-granules of platelets. A small fraction of vWF is constitutively s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b30be2f7763213f9a88710b92685b3
https://europepmc.org/articles/PMC2755043/
https://europepmc.org/articles/PMC2755043/
