Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Christopher G. R. Perry"'
Autor:
Catherine A. Bellissimo, Laura N. Castellani, Michael S. Finch, Mayoorey Murugathasan, Shivam Gandhi, Gary Sweeney, Ali A. Abdul‐Sater, Rebecca E. K. MacPherson, Christopher G. R. Perry
Publikováno v:
Experimental Physiology, Vol 108, Iss 9, Pp 1108-1117 (2023)
Abstract Memory impairments have been well documented in people with Duchenne muscular dystrophy (DMD). However, the underlying mechanisms are poorly understood, and there is an unmet need to develop new therapies to treat this condition. Using a nov
Externí odkaz:
https://doaj.org/article/9aebbbcd31244b76a2b395839071d45d
Publikováno v:
Cells, Vol 13, Iss 14, p 1168 (2024)
Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease caused by mutations to the dystrophin gene, resulting in deficiency of dystrophin protein, loss of myofiber integrity in skeletal and cardiac muscle, and eventual cell death and
Externí odkaz:
https://doaj.org/article/3052f6ea53aa4bc48939dd60b4ae7440
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1407 (2024)
Duchenne muscular dystrophy (DMD) is caused by genetic mutations in the cytoskeletal-sarcolemmal anchor protein dystrophin. Repeated cycles of sarcolemmal tearing and repair lead to a variety of secondary cellular and physiological stressors that are
Externí odkaz:
https://doaj.org/article/660b13a6ab20472a90e93524f71871ae
Autor:
Keith G. Avin, Meghan C. Hughes, Neal X. Chen, Shruthi Srinivasan, Kalisha D. O’Neill, Andrew P. Evan, Robert L. Bacallao, Michael L. Schulte, Ranjani N. Moorthi, Debora L. Gisch, Christopher G. R. Perry, Sharon M. Moe, Thomas M. O’Connell
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Chronic kidney disease (CKD) leads to musculoskeletal impairments that are impacted by muscle metabolism. We tested the hypothesis that 10-weeks of voluntary wheel running can improve skeletal muscle mitochondria activity and function in a r
Externí odkaz:
https://doaj.org/article/2b201539047144c29d1abd2252d93f36
Autor:
Athan G. Dial, Cynthia M. F. Monaco, Grace K. Grafham, Nadya Romanova, Jeremy A. Simpson, Mark A. Tarnopolsky, Christopher G. R. Perry, Evangelia Kalaitzoglou, Thomas J. Hawke
Publikováno v:
Physiological Reports, Vol 8, Iss 13, Pp n/a-n/a (2020)
Abstract Type 1 diabetes (T1D) has been reported to negatively affect the health of skeletal muscle, though the underlying mechanisms are unknown. Myostatin, a myokine whose increased expression is associated with muscle‐wasting diseases, has not b
Externí odkaz:
https://doaj.org/article/3f0d1c3aee1d49cf9cf580b15ffafe79
Autor:
Sofhia V. Ramos, Meghan C. Hughes, Luca J. Delfinis, Catherine A. Bellissimo, Christopher G. R. Perry, James M. Ervasti
Publikováno v:
PLoS ONE, Vol 15, Iss 10 (2020)
In Duchenne muscular dystrophy, a lack of dystrophin leads to extensive muscle weakness and atrophy that is linked to cellular metabolic dysfunction and oxidative stress. This dystrophinopathy results in a loss of tethering between microtubules and t
Externí odkaz:
https://doaj.org/article/776749bd586142769f0077419d9a337c
Autor:
Erin R. Mandel, Emily C. Dunford, Ghoncheh Abdifarkosh, Patrick C. Turnbull, Christopher G. R. Perry, Michael C. Riddell, Tara L. Haas
Publikováno v:
Physiological Reports, Vol 5, Iss 10, Pp n/a-n/a (2017)
Abstract Sustained elevations in circulating glucocorticoids elicit reductions in skeletal muscle microvascular content, but little is known of the underlying mechanisms. We hypothesized that glucocorticoid‐induced oxidative stress contributes to t
Externí odkaz:
https://doaj.org/article/29e132e15f3641e2958e45fb009d9885
Autor:
Anna Vainshtein, Mikhaela B. Slavin, Arthur J. Cheng, Jonathan M. Memme, Ashley N. Oliveira, Christopher G. R. Perry, Ali A. Abdul-Sater, Angelo N. Belcastro, Michael C. Riddell, Matthew Triolo, Tara L. Haas, Emilie Roudier, David A. Hood
Publikováno v:
Journal of Applied Physiology. 133:1381-1393
Exercise is one of the only non-pharmacologic remedies known to counteract genetic and chronic diseases by enhancing health and improving life span. Although the many benefits of regular physical activity have been recognized for some time, the intri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c9c327f60786cf19707c0768e94cd7
https://doi.org/10.1152/japplphysiol.00475.2022
https://doi.org/10.1152/japplphysiol.00475.2022
Autor:
Kelly N. Z. Fuller, Colin S. McCoin, Harrison Stierwalt, Julie Allen, Shivam Gandhi, Christopher G. R. Perry, Purevsuren Jambal, Kartik Shankar, John P. Thyfault
Publikováno v:
The Journal of physiologyReferences. 600(24)
Compared to age-matched men, pre-menopausal women show greater resilience against cardiovascular disease (CVD), hepatic steatosis, diabetes and obesity - findings that are widely attributed to oestrogen. However, meta-analysis data suggest that curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2790309b5b3d5d8df812e4dad8393e7
https://pubmed.ncbi.nlm.nih.gov/36326014
https://pubmed.ncbi.nlm.nih.gov/36326014
Publikováno v:
American journal of physiology. Cell physiology. 323(3)
Mitochondrial stress may be a secondary contributor to muscle weakness in inherited muscular dystrophies. Duchenne muscular dystrophy has received the majority of attention, whereby most discoveries suggest mitochondrial ATP synthesis may be reduced.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9f2825c312c3aa07c40f03cfcf65bb
https://pubmed.ncbi.nlm.nih.gov/35816642
https://pubmed.ncbi.nlm.nih.gov/35816642