Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Christopher G. Levins"'
Autor:
Dganit Danino, Omar F. Khan, Klaus Charisse, Matthew J. Webber, Akin Akinc, Yizhou Dong, Tatiana Novobrantseva, Shan Jiang, Roman L. Bogorad, Vera M. Ruda, Matthias Nahrendorf, Taylor E. Shaw, Dayna K. Mudge, Rubin M. Tuder, Aude Thiriot, Andrew Bader, Daniel G. Anderson, Mark W. Kieran, Hendrik B. Sager, Tim Racie, Christopher G. Levins, Lauren Speciner, Partha Dutta, Ulrich H. von Andrian, Robert Langer, Mario F. Perez, Siddharth Jhunjunwala, Kevin Fitzgerald, Avi Schroeder, Kamaljeet Singh Sandhu, Dipak Panigrahy, James E. Dahlman, Ludmila Abezgauz, Lynelle P. Smith, Hao Yin, Danielle Seedorf, Abigail K. R. Lytton-Jean, Victor Koteliansky, Gaurav Sahay, Carmen M. Barnés, Brian T. Kalish, Yiping Xing, Apeksha Dave
Publikováno v:
PMC
Dysfunctional endothelium contributes to more diseases than any other tissue in the body. Small interfering RNAs (siRNAs) can help in the study and treatment of endothelial cells in vivo by durably silencing multiple genes simultaneously, but efficie
Autor:
Daniel G. Anderson, James E. Dahlman, Kevin T. Love, Christopher G. Levins, Ahmed A. Eltoukhy, Avi Schroeder, Gaurav Sahay, Shan Jiang, Yingxia Wang
Publikováno v:
PMC
RNA interference (RNAi) is a highly specific gene-silencing mechanism triggered by small interfering RNA (siRNA). Effective intracellular delivery requires the development of potent siRNA carriers. Here, we describe the synthesis and screening of a s
Publikováno v:
Journal of Internal Medicine. 267:9-21
RNA interference (RNAi) is a specific gene-silencing mechanism triggered by small interfering RNA (siRNA). The application of RNAi in the clinic requires the development of safe and effective delivery systems. Inspired by progress with lipid-based sy
Autor:
Christopher G. Levins, Zhao-Kui Wan
Publikováno v:
Organic Letters. 10:1755-1758
We present an efficient, room temperature procedure for the preparation of 2-amino-1,3,4-oxadiazoles. Oxadiazol-2-ones can be activated for SNAr substitution using phosphonium reagents (e.g., BOP). This approach provides convenient access to N,N-disu
Publikováno v:
Organic Letters. 8:2807-2810
[reaction: see text] We introduce all stereoisomers of a bis-amino acid building block derived from trans-4-hydroxy-L-proline. This small library of monomers allows arbitrary stereochemical configuration at any chiral center within our spiro-ladder o
Autor:
Daniel G. Anderson, Shan Jiang, Christopher G. Levins, Avi Schroeder, Brian Joseph, Christian J. Kastrup, Yingxia Wang, Robert Langer, Michael S. Goldberg, Sneha T. Kannan
Publikováno v:
PMC
The development of responsive nanomaterials, nanoscale systems that actively respond to stimuli, is one general goal of nanotechnology. Here we develop nanoparticles that can be controllably triggered to synthesize proteins. The nanoparticles consist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580616dc746fb50a69e45d1c1858d7f9
https://orcid.org/0000-0003-4255-0492
https://orcid.org/0000-0003-4255-0492
Autor:
Tatiana Novobrantseva, Haeshin Lee, Christina Cortez, Kevin T. Love, Shan Jiang, William Querbes, Christopher Zurenko, Ying Fei Li, Christopher G. Levins, Kathryn A. Whitehead, Gaurav Sahay, Abigail K. R. Lytton-Jean, Patrick Fenton, Arturo J. Vegas, Janice Jang, Robert Langer, Sean P. Collins, Minglin Ma, Hao Cheng, Daniel G. Anderson, Lutz Nuhn, Daniel J. Siegwart
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 108(32)
Analogous to an assembly line, we employed a modular design for the high-throughput study of 1,536 structurally distinct nanoparticles with cationic cores and variable shells. This enabled elucidation of complexation, internalization, and delivery tr
Autor:
William Querbes, Daniel G. Anderson, Kathryn A. Whitehead, Kevin Fitzgerald, Timothy Racie, Liu Liang Qin, Antonin de Fougerolles, J. Robert Dorkin, Kerry Peter Mahon, Christopher G. Levins, Maria Frank-Kamenetsky, Robert Langer, Akin Akinc, Victor Koteliansky, June Qin, William Cantley, Rene Alvarez, Dinah W.Y. Sah, Kevin T. Love, Ka Ning Yip
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(5)
Significant effort has been applied to discover and develop vehicles which can guide small interfering RNAs (siRNA) through the many barriers guarding the interior of target cells. While studies have demonstrated the potential of gene silencing in vi
Autor:
Zhao-Kui Wan, Christopher G. Levins
Publikováno v:
ChemInform. 39
We present an efficient, room temperature procedure for the preparation of 2-amino-1,3,4-oxadiazoles. Oxadiazol-2-ones can be activated for SNAr substitution using phosphonium reagents (e.g., BOP). This approach provides convenient access to N,N-disu
Autor:
Zhao-Kui Wan, Tarek S. Mansour, Christopher G. Levins, Sumrit Wacharasindhu, Keiko Tabei, Melissa Lin
Publikováno v:
ChemInform. 39