Zobrazeno 1 - 10 of 71 pro vyhledávání: '"Christopher G. Hubert"'
1
Akademický článek
Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches
Autor: Sajina Shakya, Anthony D. Gromovsky, James S. Hale, Arnon M. Knudsen, Briana Prager, Lisa C. Wallace, Luiz O. F. Penalva, H. Alex Brown, Bjarne W. Kristensen, Jeremy N. Rich, Justin D. Lathia, J. Mark Brown, Christopher G. Hubert
Publikováno v: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract Glioblastoma (GBM) displays marked cellular and metabolic heterogeneity that varies among cellular microenvironments within a tumor. Metabolic targeting has long been advocated as a therapy against many tumors including GBM, but how lipid me
Externí odkaz: https://doaj.org/article/f740fb738c5c45e4ad68a8ab8f9b28c9
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2
Akademický článek
361 WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma
Autor: Christopher Hubert, Kelly Mitchell, Samuel Sprowls, Sajina Shakya, Sonali Arora, Daniel J. Silver, Christopher M. Goins, Lisa Wallace, Gustavo Roversi, Rachel Schafer, Kristen Kay, Tyler E. Miller, Adam Lauko, John Bassett, Anjali Kashyap, J. D’Amato Kass, Erin E. Mulkearns-Hubert, Sadie Johnson, Joseph Alvarado, Jeremy N. Rich, Patrick J. Paddison, Anoop P. Patel, Shaun R. Stauffer, Christopher G. Hubert, Justin D. Lathia
Publikováno v: Journal of Clinical and Translational Science, Vol 7, Pp 107-107 (2023)
OBJECTIVES/GOALS: Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors that are driven by populations of cancer stem cells (CSCs). In this study, we perform an epigenetic-focused functional genomics screen in GBM organoids and identify
Externí odkaz: https://doaj.org/article/38b0f34846504b9fac37c7e24f076612
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3
Akademický článek
Three-dimensional organoid culture unveils resistance to clinical therapies in adult and pediatric glioblastoma
Autor: Swetha J. Sundar, Sajina Shakya, Austin Barnett, Lisa C. Wallace, Hyemin Jeon, Andrew Sloan, Violette Recinos, Christopher G. Hubert
Publikováno v: Translational Oncology, Vol 15, Iss 1, Pp 101251- (2022)
Background: Glioblastoma (GBM) is the most common primary brain tumor with a dismal prognosis. The inherent cellular diversity and interactions within tumor microenvironments represent significant challenges to effective treatment. Traditional cultur
Externí odkaz: https://doaj.org/article/7a95975469164d588ba4aae539bafb71
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4
Akademický článek
Differential Connexin Function Enhances Self-Renewal in Glioblastoma
Autor: Masahiro Hitomi, Loic P. Deleyrolle, Erin E. Mulkearns-Hubert, Awad Jarrar, Meizhang Li, Maksim Sinyuk, Balint Otvos, Sylvain Brunet, William A. Flavahan, Christopher G. Hubert, Winston Goan, James S. Hale, Alvaro G. Alvarado, Ao Zhang, Mark Rohaus, Muna Oli, Vinata Vedam-Mai, Jeff M. Fortin, Hunter S. Futch, Benjamin Griffith, Qiulian Wu, Chun-hong Xia, Xiaohua Gong, Manmeet S. Ahluwalia, Jeremy N. Rich, Brent A. Reynolds, Justin D. Lathia
Publikováno v: Cell Reports, Vol 11, Iss 7, Pp 1031-1042 (2015)
The coordination of complex tumor processes requires cells to rapidly modify their phenotype and is achieved by direct cell-cell communication through gap junction channels composed of connexins. Previous reports have suggested that gap junctions are
Externí odkaz: https://doaj.org/article/494a4a229a984f468e7f3e93cceb546e
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