Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Christopher G. Thanos"'
Autor:
Dwaine F. Emerich, Christopher G. Thanos, Moses Goddard, Stephen J.M. Skinner, Marilyn S. Geany, William J. Bell, Briannan Bintz, Patricia Schneider, Yaping Chu, Rangasamy Suresh Babu, Cesario V. Borlongan, Kim Boekelheide, Susan Hall, Bronwyn Bryant, Jeffrey H. Kordower
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 2, Pp 471-480 (2006)
Huntington's disease (HD) results from degeneration of striatal neurons. Choroid plexus (CP) cells secrete neurotrophic factors, and CP transplants are neuroprotective in rat models of HD. To determine if similar neuroprotective effects could be obta
Externí odkaz:
https://doaj.org/article/783445b7f48e49cfa7aa0b35f236bada
Autor:
Cesario V. Borlongan, Christopher G. Thanos, Steven J. M. Skinner, Marilyn Geaney, Dwaine F. Emerich
Publikováno v:
Cell Transplantation, Vol 16 (2007)
Choroid plexus (CP) epithelial cells secrete several neurotrophic factors and have been used in transplantation studies designed to impart neuroprotection against central nervous system (CNS) trauma. In the present study, CP was isolated from adult r
Externí odkaz:
https://doaj.org/article/03e5242b486643bdb2943fcb9a87f593
Publikováno v:
Cell Transplantation, Vol 16 (2007)
Delivery of neurotrophic molecules to the brain has potential for preventing neuronal loss in neurodegenerative disorders. Choroid plexus (CP) epithelial cells secrete numerous neurotrophic factors, and encapsulated CP transplants are neuroprotective
Externí odkaz:
https://doaj.org/article/ac39d00d3eae4a898bb6e9db9896755d
Publikováno v:
Cell Transplantation, Vol 16 (2007)
Delivery of neurotrophic molecules to the CNS is a potential treatment for preventing the neuronal loss in neurological disorders such as Huntington's disease (HD). Choroid plexus (CP) epithelial cell transplants secrete several neurotrophic factors
Externí odkaz:
https://doaj.org/article/bcd04b6b743f41e29f644fb26e548d9f
Publikováno v:
Cell Transplantation, Vol 15 (2006)
Delivery of neurotrophic molecules to the CNS is a potential treatment strategy for preventing the neuronal loss accompanying many neurological disorders. Choroid plexus (CP) epithelial cells secrete a cocktail of neurotrophic factors, and encapsulat
Externí odkaz:
https://doaj.org/article/b94585670ded4f99b64ac7ef96b7101b
Publikováno v:
Cell Transplantation, Vol 14 (2005)
The choroid plexuses (CPs) play pivotal roles in the most basic aspects of neural function. Some of the roles of the CP include maintaining the extracellular milieu of the brain by actively modulating chemical exchange between the CSF and brain paren
Externí odkaz:
https://doaj.org/article/63ed2cfda5f34680a07b2c46faf62122
Publikováno v:
Cell Therapy ISBN: 9783319571522
Encapsulated beta cell therapy for the treatment of type 1 diabetes remains at the forefront of biomaterials research. With recent success in generating glucoresponsive stem cell-derived β-cells, there is a renewed sense of promise in the field driv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::526e67b21b112bdd7c8a78b01d2ae40d
https://doi.org/10.1007/978-3-319-57153-9_2
https://doi.org/10.1007/978-3-319-57153-9_2
Publikováno v:
Advanced Drug Delivery Reviews. :131-141
Delivering therapeutic molecules, including trophic factor proteins, across the blood brain barrier to the brain parenchyma to treat chronic neurodegenerative diseases remains one of the great challenges in biology. To be effective, delivery needs to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7103d2328dd96d1bfd56bc34b65ae6
https://doi.org/10.1016/j.addr.2013.07.008
https://doi.org/10.1016/j.addr.2013.07.008
Autor:
Daniel Y. Cho, Edith Mathiowitz, Joshua Reineke, A. Peter Morello, Christopher G. Thanos, Jules S. Jacob, Yu-Ting L. Dingle
Publikováno v:
Proceedings of the National Academy of Sciences. 110:13803-13808
Polymeric microspheres (MSs) have received attention for their potential to improve the delivery of drugs with poor oral bioavailability. Although MSs can be absorbed into the absorptive epithelium of the small intestine, little is known about the ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c9a58867138438b863eb30fc0518bc
https://doi.org/10.1073/pnas.1305882110
https://doi.org/10.1073/pnas.1305882110
Autor:
Dwaine F. Emerich, Christopher G. Thanos, A H Johnsen, Lars Wahlberg, Lone Fjord-Larsen, Malene Torp, Jens Tornøe, Briannan Bintz, Philip Kusk
Publikováno v:
Gene Therapy. 19:1010-1017
Nerve growth factor (NGF) is a potential therapeutic agent for Alzheimer's disease (AD) as it has positive effects on the basal forebrain cholinergic neurons whose degeneration correlates with the cognitive decline in AD. We have previously described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de49358584b47b35ba3d7d68fd119e31
https://doi.org/10.1038/gt.2011.178
https://doi.org/10.1038/gt.2011.178