Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Christopher G. Cummings"'
Publikováno v:
Tetrahedron. 69:1663-1668
A range of small molecule scaffolds have been shown to act as structural and functional mimics of α-helices by mimicking the i, i+4, and i+7 positions, often found at the interface of PPIs. These molecules, though potent, possess complicating featur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e9d9130e81d1c177648fbb3bbb7b17e
https://doi.org/10.1016/j.tet.2012.11.070
https://doi.org/10.1016/j.tet.2012.11.070
Autor:
Wesley C. Van Voorhis, Andrew D. Hamilton, Michael H. Gelb, Steven Fletcher, Kasey Rivas, William P. Katt, Christopher G. Cummings, Frederick S. Buckner, Debopam Chakrabarti, Saïd M. Sebti, Carrie Hornéy
New chemotherapeutics are urgently needed to combat malaria. We previously reported on a novel series of antimalarial, ethylenediamine-based inhibitors of protein farnesyltransferase (PFT). In the current study, we designed and synthesized a series o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74272a2eeefc79dcc51eb99fefd088a1
https://ora.ox.ac.uk/objects/uuid:83a0a956-1a28-4b39-b6e1-f088289d6c02
https://ora.ox.ac.uk/objects/uuid:83a0a956-1a28-4b39-b6e1-f088289d6c02
Autor:
Sung Youn Chang, Lorena S. Beese, Matthew P. Glenn, Said M. Sebti, Michael A. Hast, Ryan J. Floyd, Erin Pusateri Keaney, William P. Katt, Christopher G. Cummings, Andrew D. Hamilton, Michael H. Gelb, Steven Fletcher, Cynthia Bucher, Wesley C. Van Voorhis, Michelle A. Blaskovich
Publikováno v:
Journal of Medicinal Chemistry. 53:6867-6888
A potent class of anticancer, human farnesyltransferase (hFTase) inhibitors has been identified by “piggy-backing” on potent, antimalarial inhibitors of Plasmodium falciparum farnesyltransferase (PfFTase). On the basis of a 4-fold substituted eth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21318648da4f197cdb66a03371cc123e
https://doi.org/10.1021/jm1001748
https://doi.org/10.1021/jm1001748
Publikováno v:
Current opinion in chemical biology. 14(3)
Many biological processes are regulated by protein-protein interactions (PPIs) and as such their misregulation can cause a multitude of diseases. Often the interactions between large proteins are mediated by small protein secondary structural domains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a4e201275a7b2522f1ca7a6df8b8a6
http://ora.ox.ac.uk/objects/uuid:387385b2-7815-401a-97b9-b4659637f658
http://ora.ox.ac.uk/objects/uuid:387385b2-7815-401a-97b9-b4659637f658
Autor:
Wesley C. Van Voorhis, Michael A. Hast, Said M. Sebti, Michael H. Gelb, Lorena S. Beese, Erin E. Pusateri, Christopher G. Cummings, Michelle A. Blaskovich, Kasey Rivas, Andrew D. Hamilton, Steven Fletcher
Publikováno v:
Chemistrybiology. 16(2)
SummaryProtein farnesyltransferase (FTase) catalyzes an essential posttranslational lipid modification of more than 60 proteins involved in intracellular signal transduction networks. FTase inhibitors have emerged as a significant target for developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e531cceff87f28e0a0a9f6030117fc
https://pubmed.ncbi.nlm.nih.gov/19246009
https://pubmed.ncbi.nlm.nih.gov/19246009
Autor:
Matthew P. Glenn, Carrie Hornéy, Erin E. Pusateri, Andrew D. Hamilton, Frederick S. Buckner, Christopher G. Cummings, Sung Youn Chang, Prakash Rao Pendyala, Saïd M. Sebti, Michael H. Gelb, Wesley C. Van Voorhis, Kohei Yokoyama, Steven Fletcher, Kasey Rivas, Debopam Chakrabarti
Third world nations require immediate access to inexpensive therapeutics to counter the high mortality inflicted by malaria. Here, we report a new class of antimalarial protein farnesyltransferase (PFT) inhibitors, designed with specific emphasis on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a365945a35d04fb9bb59e150e2dc5986
https://europepmc.org/articles/PMC2728208/
https://europepmc.org/articles/PMC2728208/
Abstract B35: Dual inhibitors of FT and GGT-1 as novel therapeutic agents for K-Ras-dependent tumors
Autor:
Andrew D. Hamilton, Harshani R. Lawrence, Christopher G. Cummings, Xiaolei Zhang, Yunting Luo, Said M. Sebti, Steven Fletcher, Kazi Aslamuzzaman, Ronil Patel
Publikováno v:
Molecular Cancer Research. 12:B35-B35
Inhibition of mutant H-Ras farnesylation with farnesyltransferase inhibitors (FTIs) blocks its binding to membranes and its ability to activate oncogenic signaling. In contrast, inhibition of K-Ras farnesylation with FTIs leads to its prenylation by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2577d44d9fcbc1cbf626d46aeff8f1eb
https://doi.org/10.1158/1557-3125.rasonc14-b35
https://doi.org/10.1158/1557-3125.rasonc14-b35
Autor:
Minjung Lee, Mischa Machius, Wendy M. Stewart, Henry Shelton Earp, Susan Sather, William P. Janzen, Yingqiu Zhou, Jacqueline Norris-Drouin, Stephen V. Frye, Michael A. Stashko, Xiaodong Wang, Christopher G. Cummings, Weihe Zhang, Dmitri Kireev, Deborah DeRyckere, Douglas K. Graham, Dehui Zhang, Michael J. Miley, Debra Hunter, Gregory Kirkpatrick
Publikováno v:
Journal of Medicinal Chemistry. 57:7141-7141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::181adf50f0671d8633b840977df5f1c3
https://doi.org/10.1021/jm501216s
https://doi.org/10.1021/jm501216s
Autor:
Norbert Berndt, Steven Fletcher, Christopher G. Cummings, Said M. Sebti, Andrew D. Hamilton, Yunting Luo, Aslamuzzaman Kazi, Harshani R. Lawrence
Publikováno v:
Cancer Research. 71:620-620
Many low molecular weight GTPases such as Ras, Ral and Rho require posttranslational farnestylation or geranylgeranylation for mediating malignant transformation. This prompted the development of farnesyltransferase (FT) inhibitors (FTI) and geranylg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::918e65c5691b2604542e2ca2f3a1a03c
https://doi.org/10.1158/1538-7445.am2011-620
https://doi.org/10.1158/1538-7445.am2011-620
Autor:
Steven Fletcher, Erin Pusateri Keaney, Christopher G. Cummings, Michelle A. Blaskovich, Michael A. Hast, Matthew P. Glenn, Sung-Youn Chang, Cynthia J. Bucher, Ryan J. Floyd, William P. Katt, Michael H. Gelb, Wesley C. Van Voorhis, Lorena S. Beese, Said M. Sebti, Andrew D. Hamilton
Publikováno v:
Journal of Medicinal Chemistry; Oct2010, Vol. 53 Issue 19, p6867-6888, 22p