Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Christopher G Twitty"'
Autor:
Jack Y. Lee, Bianca Nguyen, Anandaroop Mukhopadhyay, Mia Han, Jun Zhang, Ravindra Gujar, Jon Salazar, Reneta Hermiz, Lauren Svenson, Erica Browning, H. Kim Lyerly, David A. Canton, Daniel Fisher, Adil Daud, Alain Algazi, Joseph Skitzki, Christopher G. Twitty
Publikováno v:
Molecular Therapy: Oncolytics, Vol 25, Iss , Pp 174-188 (2022)
Clinical studies have demonstrated that local expression of the cytokine IL-12 drives interferon-gamma expression and recruits T cells to the tumor microenvironment, ultimately yielding durable systemic T cell responses. Interrogation of longitudinal
Externí odkaz:
https://doaj.org/article/e9b02e1da6b143caba62a394755fbbb0
Autor:
Amy H. Lin, Christopher G. Twitty, Ryan Burnett, Andrew Hofacre, Leah A. Mitchell, Fernando Lopez Espinoza, Harry E. Gruber, Douglas J. Jolly
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 221-232 (2017)
Tumor cells express a number of immunosuppressive molecules that can suppress anti-tumor immune responses. Efficient delivery of small interfering RNAs to treat a wide range of diseases including cancers remains a challenge. Retroviral replicating ve
Externí odkaz:
https://doaj.org/article/7862354fc3bd49d99e2426c4a22b63fb
Autor:
Lawrence Fong, Adil I. Daud, Mai H. Le, Robert H. Pierce, Alan Paciorek, Li Zhang, Christopher G. Twitty, Lawrence Chen, Kathryn T. Takamura, Katy K. Tsai, Alain P. Algazi, Samantha K. Greaney
Whereas systemic IL12 is associated with potentially life-threatening toxicity, intratumoral delivery of IL12 through tavokinogene telseplasmid electroporation (tavo) is safe and can induce tumor regression at distant sites. The mechanism by which th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ba2b2721404c2e21aea696350dbd37
https://doi.org/10.1158/2326-6066.c.6550222.v1
https://doi.org/10.1158/2326-6066.c.6550222.v1
Autor:
Lawrence Fong, Adil I. Daud, Mai H. Le, Robert H. Pierce, Alan Paciorek, Li Zhang, Christopher G. Twitty, Lawrence Chen, Kathryn T. Takamura, Katy K. Tsai, Alain P. Algazi, Samantha K. Greaney
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd29f92e0542fe150bc20a0a767f4d2
https://doi.org/10.1158/2326-6066.22543339.v1
https://doi.org/10.1158/2326-6066.22543339.v1
Autor:
Lawrence Fong, Adil I. Daud, Mai H. Le, Robert H. Pierce, Alan Paciorek, Li Zhang, Christopher G. Twitty, Lawrence Chen, Kathryn T. Takamura, Katy K. Tsai, Alain P. Algazi, Samantha K. Greaney
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a38f95a7d47fb4f42ac46e7f9e5046
https://doi.org/10.1158/2326-6066.22543342.v1
https://doi.org/10.1158/2326-6066.22543342.v1
Autor:
Christopher G. Twitty, David A. Canton, Adil I. Daud, Alain P. Algazi, William L. Redmond, Annah S. Rolig, Lauren Svenson, Reneta Hermiz, Jon Salazar, Ravindra Gujar, Anandaroop Mukhopadhyay, Jun Zhang, Erica Browning, Jack Y. Lee, Bianca Nguyen, Mia Han
Supplementary Data from Intratumoral Electroporation of Plasmid Encoded IL12 and Membrane-Anchored Anti-CD3 Increases Systemic Tumor Immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3eed745c165b1ea13499b90e81ce99
https://doi.org/10.1158/1541-7786.22527632
https://doi.org/10.1158/1541-7786.22527632
Autor:
Christopher G. Twitty, David A. Canton, Adil I. Daud, Alain P. Algazi, William L. Redmond, Annah S. Rolig, Lauren Svenson, Reneta Hermiz, Jon Salazar, Ravindra Gujar, Anandaroop Mukhopadhyay, Jun Zhang, Erica Browning, Jack Y. Lee, Bianca Nguyen, Mia Han
Supplementary Figure from Intratumoral Electroporation of Plasmid Encoded IL12 and Membrane-Anchored Anti-CD3 Increases Systemic Tumor Immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20466e5b01e1b903fcdd11ec077f3365
https://doi.org/10.1158/1541-7786.22527629
https://doi.org/10.1158/1541-7786.22527629
Autor:
Mia Han, Bianca Nguyen, Jack Y. Lee, Erica Browning, Jun Zhang, Anandaroop Mukhopadhyay, Ravindra Gujar, Jon Salazar, Reneta Hermiz, Lauren Svenson, Annah S. Rolig, William L. Redmond, Alain P. Algazi, Adil I. Daud, David A. Canton, Christopher G. Twitty
Publikováno v:
Molecular Cancer Research. 20:983-995
Intratumoral delivery of plasmid IL12 via electroporation (IT-tavo-EP) induces localized expression of IL12 leading to regression of treated and distant tumors with durable responses and minimal toxicity. A key driver in amplifying this local therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb1d8e7ce24644cfbc5c4231489a40c
https://doi.org/10.1158/1541-7786.mcr-21-0834
https://doi.org/10.1158/1541-7786.mcr-21-0834
Autor:
Melinda L. Telli, Irene Wapnir, Bianca Devitt, Katharine Cuff, Hatem Soliman, Shaveta Vinayak, David A. Canton, Christopher G. Twitty, Sunny Xie, Ying Lu, Donna Bannavong, Bridget O'Keeffe, Sandra Aung, Rohit Joshi
Publikováno v:
Cancer Research. 82:P2-14
BACKGROUND: Electroporated plasmid interleukin-12 (tavokinogene telseplasmid; TAVO-EP) delivered to accessible tumors by intratumoral injection induces sustained local expression of IL-12. IL-12 is a potent immunoregulatory cytokine that plays a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53bf2b045cd6ee834f70202b48df7dfd
https://doi.org/10.1158/1538-7445.sabcs21-p2-14-06
https://doi.org/10.1158/1538-7445.sabcs21-p2-14-06
Autor:
Erika J. Crosby, H. Kim Lyerly, Takuya Osada, Christopher G. Twitty, David A. Canton, Kellie Malloy Foerter, Jendy Sell, Kim Jaffe, Donna Bannavong, Lauren Svenson, Reneta Hermiz, Erica Browning, Robert H. Pierce, Mai Hope Le, Carmen Ballesteros-Merino, Shawn M. Jensen, Carlo B. Bifulco, Bernard A. Fox, Kaitlin Zablotsky, Chaitanya R. Acharya, Irene Wapnir, Hiroshi Nagata, Melinda L. Telli
Purpose:Triple-negative breast cancer (TNBC) is an aggressive disease with limited therapeutic options. Antibodies targeting programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) have entered the therapeutic landscape in TNBC, but only a minor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e551cda28c1fd25f0ef23972aa309b8
https://doi.org/10.1158/1078-0432.c.6531311.v1
https://doi.org/10.1158/1078-0432.c.6531311.v1