Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christopher Felix Krombholz"'
Autor:
Silvia Fluhr, Christopher Felix Krombholz, Angelina Meier, Thomas Epting, Oliver Mücke, Christoph Plass, Charlotte M. Niemeyer, Christian Flotho
Publikováno v:
Epigenetics, Vol 12, Iss 8, Pp 715-723 (2017)
Increased levels of fetal hemoglobin (HbF) are a hallmark of more than half of the children diagnosed with juvenile myelomonocytic leukemia (JMML). Elevated HbF levels in JMML are associated with DNA hypermethylation of distinct gene promoter regions
Externí odkaz:
https://doaj.org/article/46b22d2d9f224fcfaa035f5003c1a5c6
Autor:
Christopher Felix Krombholz, Konrad Aumann, Matthias Kollek, Daniela Bertele, Silvia Fluhr, Mirjam Kunze, Charlotte M. Niemeyer, Christian Flotho, Miriam Erlacher
Publikováno v:
Haematologica, Vol 101, Iss 5 (2016)
Juvenile myelomonocytic leukemia is a clonal malignant disease affecting young children. Current cure rates, even with allogeneic hematopoietic stem cell transplantation, are no better than 50%–60%. Pre-clinical research on juvenile myelomonocytic
Externí odkaz:
https://doaj.org/article/2e5fcaaa8fee447fb8e7c89cf5329bca
Autor:
Charlotte M. Niemeyer, Christian Molnar, Matthias Kollek, Christopher Felix Krombholz, Gesina Voigt, Stefan M. Schiller, Miriam Erlacher, Ana J. García-Sáez, Mirjam Kunze, Sheila Bohler, Stephan Geley, D Bertele, Verena Labi, Fabronia Murad
Publikováno v:
The Journal of Experimental Medicine
Kollek et al. show that transient inhibition of apoptosis by short-term BCL-XL overexpression increases the viability of hematopoietic stem cells (HSCs) during engraftment and improves the outcome of HSC transplantation without signs of adverse patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb922d2ddd7f088018078b1591c0350
https://doi.org/10.1084/jem.20161721
https://doi.org/10.1084/jem.20161721
Autor:
Oliver Mücke, Thomas Epting, Charlotte M. Niemeyer, Silvia Fluhr, Christian Flotho, Christoph Plass, Christopher Felix Krombholz, Angelina Meier
Publikováno v:
Epigenetics. 12:715-723
Increased levels of fetal hemoglobin (HbF) are a hallmark of more than half of the children diagnosed with juvenile myelomonocytic leukemia (JMML). Elevated HbF levels in JMML are associated with DNA hypermethylation of distinct gene promoter regions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed836a7992e84c2ac2ef8aa5827ef49
https://doi.org/10.1080/15592294.2017.1356959
https://doi.org/10.1080/15592294.2017.1356959
Autor:
Charlotte M. Niemeyer, Matthias Kollek, Christopher Felix Krombholz, Konrad Aumann, Mirjam Kunze, Christian Flotho, D Bertele, Miriam Erlacher, Silvia Fluhr
Publikováno v:
Haematologica. 101:597-606
Juvenile myelomonocytic leukemia is a clonal malignant disease affecting young children. Current cure rates, even with allogeneic hematopoietic stem cell transplantation, are no better than 50%-60%. Pre-clinical research on juvenile myelomonocytic le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb3025487595de6a5105350fc56dea4
https://doi.org/10.3324/haematol.2015.138545
https://doi.org/10.3324/haematol.2015.138545
Autor:
Hanno Schmidt, Christopher Felix Krombholz, Bertil Schmidt, Mathias Weber, Fabian Ripp, Rene Koeppel, Thomas Hankeln, Sören Lukas Hellmann, Yongchao Liu
Publikováno v:
Bioinformatics. 33:1396-1398
Summary DNA-based methods to detect and quantify taxon composition in biological materials are often based on species-specific polymerase chain reaction, limited to detecting species targeted by the assay. Next-generation sequencing overcomes this dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726387a5f77296e1e549fd93b6221245
https://doi.org/10.1093/bioinformatics/btw822
https://doi.org/10.1093/bioinformatics/btw822
Autor:
Charlotte M. Niemeyer, Pritam Kumar Panda, Sushree Sangita Sahoo, Christoph Plass, Miriam Erlacher, Marcin W. Wlodarski, Daniel B. Lipka, Lorena Gallego Villar, Christopher Felix Krombholz, Christian Flotho
Publikováno v:
Blood. 132:4342-4342
Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm of young children that originates from early hematopoietic stem/progenitor cells. We have previously developed an in vivo disease model using xenotransplantation of primary JMML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d91986d4eb99f72a3c0c3c7224e57218
https://doi.org/10.1182/blood-2018-99-116594
https://doi.org/10.1182/blood-2018-99-116594
Autor:
Fabian, Ripp, Christopher Felix, Krombholz, Yongchao, Liu, Mathias, Weber, Anne, Schäfer, Bertil, Schmidt, Rene, Köppel, Thomas, Hankeln
Publikováno v:
BMC Genomics
Background DNA-based methods like PCR efficiently identify and quantify the taxon composition of complex biological materials, but are limited to detecting species targeted by the choice of the primer assay. We show here how untargeted deep sequencin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c60c9eedb0c023e1ac370f5607cf373
https://pubmed.ncbi.nlm.nih.gov/25081296
https://pubmed.ncbi.nlm.nih.gov/25081296
Autor:
Silvia Fluhr, Christoph Plass, Charlotte M. Niemeyer, Christopher Felix Krombholz, Christian Flotho, Angelina Meier
Publikováno v:
Blood. 126:438-438
Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative disorder of early childhood characterized by massive proliferation of not only the monocytic and granulocytic lineage but also of erythropoietic precursors. Elevated levels o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd17e7a1f696b4f6b9184659cfe449b7
https://doi.org/10.1182/blood.v126.23.438.438
https://doi.org/10.1182/blood.v126.23.438.438
Autor:
Silvia Fluhr, Christian Flotho, Tania Witte, Konrad Aumann, Daniel B. Lipka, Charlotte M. Niemeyer, Matthias Kollek, Miriam Erlacher, Christoph Plass, Christopher Felix Krombholz, Angelina Meier
Publikováno v:
Blood. 126:1655-1655
Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative disorder of early childhood with often fatal outcome. Despite many attempts to develop alternative treatment options allogeneic hematopoietic stem cell transplantation (HSCT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35f8c36cc4ec09714f5cf88c2df55ac9
https://doi.org/10.1182/blood.v126.23.1655.1655
https://doi.org/10.1182/blood.v126.23.1655.1655