Locus Coeruleus Shows a Spatial Pattern of Structural Disintegration in Parkinson's Disease

Autor: Christopher F. Madelung, David Meder, Søren A. Fuglsang, Marta M. Marques, Vincent O. Boer, Kristoffer H. Madsen, Esben T. Petersen, Anne‐Mette Hejl, Annemette Løkkegaard, Hartwig R. Siebner

Publikováno v: Madelung, C F, Meder, D, Fuglsang, S A, Marques, M M, Boer, V O, Madsen, K H, Petersen, E T, Hejl, A-M, Lokkegaard, A & Siebner, H R 2022, ' Locus Coeruleus Shows a Spatial Pattern of Structural Disintegration in Parkinson's Disease ', Movement Disorders, vol. 37, no. 3, pp. 479-489 . https://doi.org/10.1002/mds.28945
Madelung, C F, Meder, D, Fuglsang, S A, Marques, M M, Boer, V O, Madsen, K H, Petersen, E T, Hejl, A-M, Løkkegaard, A & Siebner, H R 2022, ' Locus Coeruleus Shows a Spatial Pattern of Structural Disintegration in Parkinson's Disease ', Movement Disorders, vol. 37, no. 3, pp. 479-489 . https://doi.org/10.1002/mds.28945

Background: Parkinson's disease (PD) causes a loss of neuromelanin-positive, noradrenergic neurons in the locus coeruleus (LC), which has been implicated in nonmotor dysfunction. Objectives: We used "neuromelanin sensitive" magnetic resonance imaging

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https://curis.ku.dk/ws/files/314705937/Movement_Disorders_2022_Madelung_Locus_Coeruleus_Shows_a_Spatial_Pattern_of_Structural_Disintegration_in_Parkinson_s.pdf