Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Christopher F Bennett"'
Autor:
Christopher F Bennett, Jane J Kwon, Christine Chen, Joshua Russell, Kathlyn Acosta, Nikolay Burnaevskiy, Matthew M Crane, Alessandro Bitto, Helen Vander Wende, Marissa Simko, Victor Pineda, Ryan Rossner, Brian M Wasko, Haeri Choi, Shiwen Chen, Shirley Park, Gholamali Jafari, Bryan Sands, Carissa Perez Olsen, Alexander R Mendenhall, Philip G Morgan, Matt Kaeberlein
Publikováno v:
PLoS Genetics, Vol 13, Iss 3, p e1006695 (2017)
Mitochondrial dysfunction can increase oxidative stress and extend lifespan in Caenorhabditis elegans. Homeostatic mechanisms exist to cope with disruptions to mitochondrial function that promote cellular health and organismal longevity. Previously,
Externí odkaz:
https://doaj.org/article/16244a054fa74a9d8488d864fa5e9844
Autor:
Eduardo Balsa, Elizabeth A. Perry, Christopher F. Bennett, Mark Jedrychowski, Steven P. Gygi, John G. Doench, Pere Puigserver
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mitochondrial oxidative phosphorylation produces ATP and is an important source for cellular energy equivalents. Here the authors perform a cell-based screen to identify genes that alleviate perturbed mitochondrial complex I function and identify mal
Externí odkaz:
https://doaj.org/article/6b5c34283bc544b78083839339684cb7
Autor:
Haeri Choi, Sung Chun Cho, Young Wan Ha, Billie Ocampo, Shirley Park, Shiwen Chen, Christopher F. Bennett, Jeehae Han, Ryan Rossner, Jong-Sun Kang, Yun-ll Lee, Sang Chul Park, Matt Kaeberlein
Publikováno v:
Translational Medicine of Aging, Vol 3, Iss , Pp 64-69 (2019)
The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis elegans through inhibition of pyruvate kinase and
Externí odkaz:
https://doaj.org/article/703a38fb11dc4f9488f12d04f06a6285
Publikováno v:
Nature Reviews Molecular Cell Biology. 23:817-835
Mitochondrial energetic adaptations encompass a plethora of conserved processes that maintain cell and organismal fitness and survival in the changing environment by adjusting the respiratory capacity of mitochondria. These mitochondrial responses ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32dba1e711f988c796cfddcaefd372af
https://doi.org/10.1038/s41580-022-00506-6
https://doi.org/10.1038/s41580-022-00506-6
Autor:
Conor T. Ronayne, Christopher F. Bennett, Elizabeth A. Perry, Noa Kantorovic, Pere Puigserver
Publikováno v:
bioRxiv
Mitochondrial diseases are a group of disorders defined by defects in oxidative phosphorylation caused by nuclear- or mitochondrial-encoded gene mutations. A main cellular phenotype of mitochondrial disease mutations are redox imbalances and inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279c8ed5d93387050510f66d2a0df81f
https://europepmc.org/articles/PMC10028993/
https://europepmc.org/articles/PMC10028993/
Publikováno v:
The FEBS Journal. 289:6969-6993
Mitochondrial dysfunction is increasingly appreciated as a central contributor to human disease. Oxidative metabolism at the mitochondrial respiratory chain produces ATP and is intricately tied to redox homeostasis and biosynthetic pathways. Metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cafa2f4d1311bcc5a4e766c9d84249b
https://doi.org/10.1111/febs.16195
https://doi.org/10.1111/febs.16195
Autor:
Mark P. Jedrychowski, Pedro Latorre-Muro, Christopher F. Bennett, Kamar Reda, Steven P. Gygi, Elizabeth A. Perry, Richard Porter Ladley, Katherine E. O’Malley, Chi Luo, Eduardo Balsa, Andrew G. Myers, Peter M. Wright, Pere Puigserver
Publikováno v:
Nature metabolism
Mitochondrial diseases (MDs) are a heterogeneous group of disorders resulting from mutations in nuclear or mitochondrial DNA genes encoding mitochondrial proteins1,2. MDs cause pathologies with severe tissue damage and ultimately death3,4. There are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7c377e52a0e6d3efcec8390760198b
https://doi.org/10.1038/s42255-020-00334-y
https://doi.org/10.1038/s42255-020-00334-y
Autor:
Shirley Park, Billie R. Ocampo, Matt Kaeberlein, Sang Chul Park, Shiwen Chen, Young Wan Ha, Ryan Rossner, Yun-ll Lee, Christopher F. Bennett, Jeehae Han, Haeri Choi, Jong-Sun Kang, Sung Chun Cho
Publikováno v:
Translational Medicine of Aging, Vol 3, Iss, Pp 64-69 (2019)
The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis elegans through inhibition of pyruvate kinase and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf06fa63dc5e68e87daf87a62bd3a1b
http://www.sciencedirect.com/science/article/pii/S2468501119300045
http://www.sciencedirect.com/science/article/pii/S2468501119300045
Autor:
Elizabeth A. Perry, Steven P. Gygi, Christopher L. Riley, Mark P. Jedrychowski, Pedro Latorre-Muro, Christopher F. Bennett, Katherine E. O’Malley, Eduardo Balsa, Pere Puigserver, Chi Luo
Publikováno v:
Nature chemical biology
The protein complexes of the mitochondrial electron transport chain exist in isolation and in higher order assemblies termed supercomplexes (SCs) or respirasomes (SC I+III2+IV). The association of complexes I, III and IV into the respirasome is regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d120b060c2e3433c07f1c165b5cee8b0
https://pubmed.ncbi.nlm.nih.gov/33723432
https://pubmed.ncbi.nlm.nih.gov/33723432
Autor:
Christopher F. Bennett, Steven P. Gygi, Elizabeth A. Perry, Pere Puigserver, John G. Doench, Eduardo Balsa, Mark P. Jedrychowski
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Nature Communications
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Nature Communications
Biblos-e Archivo. Repositorio Institucional de la UAM
Electron transport chain (ETC) defects occurring from mitochondrial disease mutations compromise ATP synthesis and render cells vulnerable to nutrient and oxidative stress conditions. This bioenergetic failure is thought to underlie pathologies assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95f128f878290842de9ec12cc621065
http://hdl.handle.net/10261/222158
http://hdl.handle.net/10261/222158