Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Christopher Esk"'
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
Chickpea (Cicer arietinum L.) is a staple food in many developing countries where iron (Fe) deficiency often occurs in their population. The crop is a good source of protein, vitamins, and micronutrients. Fe biofortification in chickpea can be part o
Externí odkaz:
https://doaj.org/article/cebc82b1f2e74b1cbac02dada3f1f89f
Autor:
Florian G Pflug, Simon Haendeler, Christopher Esk, Dominik Lindenhofer, Jürgen A Knoblich, Arndt von Haeseler
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 4, p e1012054 (2024)
Neural organoids model the development of the human brain and are an indispensable tool for studying neurodevelopment. Whole-organoid lineage tracing has revealed the number of progenies arising from each initial stem cell to be highly diverse, with
Externí odkaz:
https://doaj.org/article/875383fb62c94a9a84aa0a0fb8677bdc
Autor:
Sachiko Hoshino, Kazuho Sakamoto, Stéphane Vassilopoulos, Stéphane M Camus, Christine A Griffin, Christopher Esk, Jorge A Torres, Norio Ohkoshi, Akiko Ishii, Akira Tamaoka, Birgit H Funke, Raju Kucherlapati, Marta Margeta, Thomas A Rando, Frances M Brodsky
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77787 (2013)
Mobilization of the GLUT4 glucose transporter from intracellular storage vesicles provides a mechanism for insulin-responsive glucose import into skeletal muscle. In humans, clathrin isoform CHC22 participates in formation of the GLUT4 storage compar
Externí odkaz:
https://doaj.org/article/34c19186a4ad4523b8570732b1bc950e
Autor:
Ábel Vértesy, Oliver L. Eichmueller, Julia Naas, Maria Novatchkova, Christopher Esk, Meritxell Balmaña, Sabrina Ladstaetter, Christoph Bock, Arndt von Haeseler, Juergen A. Knoblich
Organoids enable disease modeling in complex and structured human tissue,in vitro. Like most 3D models, they lack sufficient oxygen supply, leading to cellular stress. These negative effects are particularly prominent in complex models, like brain or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5c3282699a2e75bd98d8c2077af54bb
https://doi.org/10.1101/2022.03.11.483643
https://doi.org/10.1101/2022.03.11.483643
Autor:
Ulrich Elling, Arndt von Haeseler, Florian G. Pflug, Simon Haendeler, Johannes Zuber, Benoit Schroeder, Dominik Lindenhofer, Christopher Esk, Joshua A. Bagley, Jürgen A. Knoblich, Roelof A. Wester
Publikováno v:
Science
Functional screen for microcephaly genes Genetic screens are widely used to identify regulators in biological processes. Human screens are currently limited to two-dimensional cell cultures, which lack the ability to score tissue-dependent gene funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6facf7c63669d0dcafafee79ebfd0d1e
https://doi.org/10.1126/science.abb5390
https://doi.org/10.1126/science.abb5390
Autor:
Astrid Hagelkruys, Marion Horrer, Jasmin Taubenschmid-Stowers, Anoop Kavirayani, Maria Novatchkova, Michael Orthofer, Tsung-Pin Pai, Domagoj Cikes, Sergei Zhuk, Meritxell Balmaña, Christopher Esk, Rubina Koglgruber, Paul Moeseneder, Jelena Lazovic, Lydia M. Zopf, Shane J.F. Cronin, Ulrich Elling, Jürgen A. Knoblich, Josef M. Penninger
Publikováno v:
Science Advances, 8 (44)
The HUSH (human silencing hub) complex contains the H3K9me3 binding protein M-phase phosphoprotein 8 (MPP8) and recruits the histone methyltransferase SETDB1 as well as Microrchidia CW-type zinc finger protein 2 (MORC2). Functional and mechanistic st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c7aeac0b55b660888249551a94ffda
Autor:
Maria Novatchkova, Meritxell Balmaña, Shane J. F. Cronin, Anoop Kavirayani, Astrid Hagelkruys, Domagoj Cikes, Josef M. Penninger, Michael Orthofer, Christopher Esk, Juergen A. Knoblich, Rubina Koglgruber, Sergei Zhuk, Ulrich Elling, Tsung-Pin Pai, Marion Horrer, Jasmin Taubenschmid-Stowers
Fine-tuning of neural connectivity is important for cerebral functions and brain evolution. Protocadherins provide barcodes for neuronal identity as well as synapse formation and expansion of protocadherin cluster genes has been linked to advanced co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9225e6361d2febef1aeb1ee67e280e5
https://doi.org/10.1101/2021.11.29.466909
https://doi.org/10.1101/2021.11.29.466909
Autor:
Florian G. Pflug, Christopher Esk, Simon Haendeler, Arndt von Haeseler, Dominik Lindenhofer, Jürgen A. Knoblich
Cerebral organoids model the development of the human brain and have become an indispensable tool for studying neural development and neuro-developmental diseases. Comprehensive whole-organoid lineage tracing has revealed the fates of the lineages ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe6656690c6e018dcd582d3a2b371016
https://doi.org/10.1101/2021.10.06.463206
https://doi.org/10.1101/2021.10.06.463206
Autor:
Daniel W. Gerlich, Juan Pablo Fededa, Huili Zheng, Christopher Esk, Wei Yan, Klaus Ebnet, Shuiqiao Yuan, Rugile Stanyte, Juergen A. Knoblich, Beata Mierzwa
Publikováno v:
The EMBO Journal
Correct orientation of the mitotic spindle determines the plane of cellular cleavage and is crucial for organ development. In the developing cerebral cortex, spindle orientation defects result in severe neurodevelopmental disorders, but the precise m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b139017591696a205af76a8582b9be67
http://europepmc.org/articles/PMC5109238
http://europepmc.org/articles/PMC5109238
Autor:
Juergen A. Knoblich, Beiyuan Fu, Christopher Esk, Manfred Boehm, Martin Aichinger, Joshua A. Bagley, Chukwuma A. Agu, Josef M. Penninger, Fengtang Yang, Dominik Lindenhofer, Jasmin Taubenschmid, Alexandra Leopoldi, Guibin Chen, Johannes Zuber, Nikolaus Wick, Reiner A. Wimmer, Maria Novatchkova, Brigitte Hantusch, Monika Hämmerle, Dontscho Kerjaschki
Publikováno v:
Nature. 565(7740)
The increasing prevalence of diabetes has resulted in a global epidemic1. Diabetes is a major cause of blindness, kidney failure, heart attacks, stroke and amputation of lower limbs. These are often caused by changes in blood vessels, such as the exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409d14196b3fb5f595434ea6815a689e
https://pubmed.ncbi.nlm.nih.gov/30943391
https://pubmed.ncbi.nlm.nih.gov/30943391