Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Christopher E. Rudd"'
Autor:
Thai Hien Tu, Ami Grunbaum, François Santinon, Alexandra Kazanova, Nicholas Rozza, Richard Kremer, Catalin Mihalcioiu, Christopher E. Rudd
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract COVID-19, caused by SARS-CoV-2, can lead to a severe inflammatory disease characterized by significant lymphopenia. However, the underlying cause for the depletion of T-cells in COVID-19 patients remains incompletely understood. In this stud
Externí odkaz:
https://doaj.org/article/f893adaa54fc42cb8cdbad8e742eed76
Autor:
Silvia Guil-Luna, Aurora Rivas-Crespo, Carmen Navarrete-Sirvent, Ana Mantrana, Alejandra Pera, Rafael Mena-Osuna, Marta Toledano-Fonseca, María Victoria García-Ortíz, Carlos Villar, Maria Teresa Sánchez-Montero, Janna Krueger, Francisco Javier Medina-Fernández, Juan De La Haba-Rodríguez, Auxiliadora Gómez-España, Enrique Aranda, Christopher E. Rudd, Antonio Rodríguez-Ariza
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115592- (2023)
Introduction: Glycogen synthase kinase 3 (GSK-3) has been proposed as a novel cancer target due to its regulating role in both tumor and immune cells. However, the connection between GSK-3 and immunoevasive contexture, including tumor budding (TB) ha
Externí odkaz:
https://doaj.org/article/77ecc79605674de6b8a6c57e14222455
Autor:
François Santinon, Bennani Fatima Ezzahra, Meriem Bachais, Alain Sarabia Pacis, Christopher E. Rudd
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract PD-1 immune checkpoint blockade against inhibitory receptors such as receptor programmed cell death-1 (PD-1), has revolutionized cancer treatment. Effective immune reactivity against tumour antigens requires the infiltration and activation o
Externí odkaz:
https://doaj.org/article/9ff18432cb50407a81c7520ea490f4ce
Autor:
Fatima Ezzahra Bennani, Khalid Karrouchi, Latifa Doudach, Mario Scrima, Noor Rahman, Luca Rastrelli, Trina Ekawati Tallei, Christopher E. Rudd, My El Abbes Faouzi, M’hammed Ansar
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 11, Pp 5312-5351 (2022)
Despite continual efforts being made with multiple clinical studies and deploying cutting-edge diagnostic tools and technologies, the discovery of new cancer therapies remains of severe worldwide concern. Multiple drug resistance has also emerged in
Externí odkaz:
https://doaj.org/article/6e1daa3dfa014fd2ab03d3109669e8a1
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
T-cell activation is a complex process involving a network of kinases and downstream molecular scaffolds or adaptors that integrate surface signals with effector functions. One key immune-specific adaptor is Src kinase-associated phosphoprotein 1 (SK
Externí odkaz:
https://doaj.org/article/4e98e2eee1b1411f841d15412e47181c
Autor:
Fatima Ezzahra Bennani, Latifa Doudach, Khalid Karrouchi, Youssef El rhayam, Christopher E. Rudd, M’hammed Ansar, My El Abbes Faouzi
Publikováno v:
Heliyon, Vol 8, Iss 8, Pp e10003- (2022)
Despite the decades of scientific studies for developing promising new therapies, cancer remains a major cause of illness and mortality, worldwide. Several cancer types are the major topic of research in drug discovery programs due to their global in
Externí odkaz:
https://doaj.org/article/8661bc09f635410b929a88aa6b8d7a3c
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/2252787a725e43b0b39335ddf0857951
Autor:
Alison Taylor, Christopher E. Rudd
Publikováno v:
BMC Research Notes, Vol 13, Iss 1, Pp 1-7 (2020)
Abstract Objective The threonine/serine kinase glycogen synthase kinase 3 (GSK-3) targets multiple substrates in T-cells, regulating the expression of Tbet and PD-1 on T-cells. However, it has been unclear whether GSK-3 can affect the motility of T-c
Externí odkaz:
https://doaj.org/article/3e67b0601bb34177ae3e5c4e12bf4d39
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103295- (2021)
Summary: Current therapies to treat coronavirus disease 2019 (COVID-19) involve vaccines against the spike protein S1 of SARS-CoV-2. Here, we outline an alternative approach involving chimeric antigen receptors (CARs) in T cells (CAR-Ts). CAR-T recog
Externí odkaz:
https://doaj.org/article/92a1ae3a31c64365ad85696fa463ec73
Autor:
Lynette Steele, Aarren J. Mannion, Gary Shaw, Kenneth A. Maclennan, Graham P. Cook, Christopher E. Rudd, Alison Taylor
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102555- (2021)
Summary: Glycogen synthase kinase-3 (GSK-3) is a positive regulator of PD-1 expression in CD8+ T cells and GSK-3 inhibition enhances T cell function and is effective in the control of tumor growth. GSK-3 has two co-expressed isoforms, GSK-3α and GSK
Externí odkaz:
https://doaj.org/article/3f9855539d254976a5185ff195874f3e