Výsledky vyhledávání - "Christopher E. Katz"

Process Development and Scale-up of Fully Synthetic Tetracycline TP-2758: A Potent Antibacterial Agent with Excellent Oral Bioavailability

Autor: John Niu, Yonghong Deng, Magnus Ronn, Zhijian Zhu, Philip C. Hogan, Chi-Li Chen, Diana K. Hunt, Minsheng He, Wu-Yan Zhang, Xiao-Yi Xiao, Cuixiang Sun, Christopher E. Katz, Nicholas Dunwoody

Publikováno v: Organic Process Research & Development. 20:284-296

Process research and development of the fully synthetic broad spectrum tetracycline TP-2758, with a chiral pyrrolidine side chain at the C-8 position, is described. The process utilizes two key intermediates, 7 and 10, in a convergent approach that a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::757978d468e88e7bf9bb08c427f0b222
https://doi.org/10.1021/acs.oprd.5b00404

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Synthesis and Biological Evaluation of 8-Aminomethyltetracycline Derivatives as Novel Antibacterial Agents

Autor: Trudy H. Grossman, Minsheng He, Chi-Li Chen, Joyce A. Sutcliffe, Corey Fyfe, Wu-Yan Zhang, Zhijian Zhu, Magnus Ronn, Diana K. Hunt, Yonghong Deng, Xiao-Yi Xiao, John Niu, Christopher E. Katz, Cuixiang Sun, Catherine Achorn, William J. O’Brien, Philip C. Hogan, Roger B. Clark

Publikováno v: Journal of Medicinal Chemistry. 56:8112-8138

The C-8 position of the tetracyclines has been largely underexplored because of limitations in traditional semisynthetic techniques. Employing a total synthetic approach allowed for modifications at the C-7 and C-8 positions, enabling the generation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5772e692d3ba05ed3fa43ae2aaeb375f
https://doi.org/10.1021/jm401211t

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Process R&D of Eravacycline: The First Fully Synthetic Fluorocycline in Clinical Development

Autor: Wu-Yan Zhang, Zhijian Zhu, Philip C. Hogan, Magnus Ronn, Chi-Li Chen, John Niu, Yonghong Deng, Christopher E. Katz, Roger B. Clark, Xiao-Yi Xiao, Diana K. Hunt, Cuixiang Sun, Minsheng He, Olga Gilicky, Nicholas Dunwoody

Publikováno v: Organic Process Research & Development. 17:838-845

Process research and development of the first fully synthetic broad spectrum 7-fluorotetracycline in clinical development is described. The process utilizes two key intermediates in a convergent approach. The key transformation is a Michael–Dieckma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8adac5b66737a518fc9a0ca8b62dbae8
https://doi.org/10.1021/op4000219

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A Tandem Prins/Schmidt Reaction Approach to Marine Alkaloids: Formal and Total Syntheses of Lepadiformines A and C

Autor: Jeffrey Aubé, Sze-Wan Li, Christopher E. Katz, David Vander Velde, Angelica M. Meyer

Publikováno v: Organic Letters. 12:1244-1247

The tricyclic core of the cylindricine or lepadiformine families of alkaloid natural products was assembled via a Prins addition/intramolecular Schmidt rearrangement under Lewis acid conditions. Both single-pot and two-stage variations of this proces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc88c32f3677109ab69f01c2985c7c1
https://doi.org/10.1021/ol100113r

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Asymmetric Schmidt Reaction of Hydroxyalkyl Azides with Ketones

Autor: D. Srinivasa Reddy, Kelly Wayne Furness, Jeffrey Aubé, Brenton T. Smith, Vijaya Gracias, Kiran Sahasrabudhe, Christopher E. Katz

Publikováno v: Journal of the American Chemical Society. 125:7914-7922

An asymmetric equivalent of the Schmidt reaction permits stereocontrol in ring expansions of symmetrical cyclohexanones. The procedure involves the reaction of chiral 1,2- and 1,3-hydroxyalkyl azides with ketones under acid catalysis; the initial rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d496d99fceec2d3861d8e1cf53338b05
https://doi.org/10.1021/ja0348896

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Potentiometric and spectroscopic studies of copper(II) complexes of bis(1,4,7-triazacyclononane) ligands containing polymethylene and xylyl linker groups

Autor: Melissa Watson, Leverett J. Zompa, Tamy Israel, Barnali DasGupta, Christopher E. Katz

Publikováno v: Inorganica Chimica Acta. 292:172-181

Copper(II) complexes of bis(1,4,7-triazacyclononane) ligands with seven- and eight-membered polymethylene chains and xylyl bridging groups were studied in aqueous solution by pH potentiometry and UV–Vis spectroscopy. Equilibrium modeling of the dat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7323b3c26bc29c82fc8c0ceda956e2a2
https://doi.org/10.1016/s0020-1693(99)00186-3

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Highly Stereoselective Ring Expansion Reactions Mediated by Attractive Cation-n Interactions

Autor: Sherriel Smith, Benjamin Neuenswander, Timothy P Ribelin, Donna G. English, Jennifer L. Poutsma, Jeffrey Aubé, Christopher E. Katz, Anna K. Manukyan, Victor W. Day

Publikováno v: Angewandte Chemie International Edition. 47:6233-6235

Most stereoselective reactions are ruled by steric effects. In particular, kinetically controlled asymmetric transformations utilizing chiral reagent, auxiliaries, or catalysts succeed due to energy differences in transition states that most often ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd53858a9c357c3e22145c366af6adf
https://doi.org/10.1002/anie.200801591

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