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pro vyhledávání: '"Christopher E. Ing"'
Autor:
Megumi Yamashita, Priscilla S.-W. Yeung, Christopher E. Ing, Beth A. McNally, Régis Pomès, Murali Prakriya
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Store-operated Ca2+channels (CRAC) are involved in several cellular functions. Here the authors identify a hydrophobic gate in the CRAC pore and show that CRAC activation by STIM1 involves rotation of the pore helix that hydrates this region to allow
Externí odkaz:
https://doaj.org/article/d822026f02ee422589e1d171ef62a857
Publikováno v:
eLife, Vol 9 (2020)
Sulfur-aromatic interactions occur in the majority of protein structures, yet little is known about their functional roles in ion channels. Here, we describe a novel molecular motif, the M101 gate latch, which is essential for gating of human Orai1 c
Externí odkaz:
https://doaj.org/article/6c73ba37cc954bfc9aeac83928813135
Publikováno v:
Biophysical Journal. 116:372a