Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christopher E. Helt"'
Publikováno v:
Cell Cycle. 4:529-532
The toroidal Rad9-Rad1-Hus1 checkpoint complex (9-1-1) is structurally similar to the proliferating cell nuclear antigen (PCNA), which serves as a sliding clamp platform for DNA replication and repair. 9-1-1 has been characterized as a sensor of DNA
Publikováno v:
Journal of Biological Chemistry. 280:1186-1192
The ataxia telangiectasia mutated (ATM) and ATR (ATM and Rad3-related) protein kinases exert cell cycle delay, in part, by phosphorylating Checkpoint kinase (Chk) 1, Chk2, and p53. It is well established that ATR is activated following UV light-induc
Autor:
Robert A. Bambara, Michael A. O'Reilly, Rhonda J. Staversky, Peter C. Keng, Yi Jang Lee, Christopher E. Helt
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 286:L506-L513
This study investigates molecular mechanisms underlying cell cycle arrest when cells are exposed to high levels of oxygen (hyperoxia). Hyperoxia has previously been shown to increase expression of the cell cycle regulators p53 and p21. In the current
Publikováno v:
Toxicological Sciences. 63:214-222
The beneficial effects of supplemental oxygen delivered to patients suffering from acute respiratory distress is offset by its reduction to genotoxic reactive oxygen species (ROS) that inhibit proliferation and kill pulmonary cells. Cells respond to
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 280:L617-L626
Previous studies have shown that hyperoxia inhibits proliferation and increases the expression of the tumor suppressor p53 and its downstream target, the cyclin-dependent kinase inhibitor p21CIP1/WAF1, which inhibits proliferation in the G1 phase of
Autor:
Peter F. Vitiello, Sean C. Gehen, Christopher E. Helt, Rhonda J. Staversky, Michael A. O'Reilly, Arshad Rahman, Peter C. Keng
Publikováno v:
Free radical biologymedicine. 41(4)
p21Cip1/WAF1/Sdi1 is a major transcriptional target of p53 that promotes survival of cells exposed to continuous oxidative stress caused by hyperoxia. Because p21 can protect against genotoxic stress by reducing p53-dependent transcription of the pro
Publikováno v:
Cell cycle (Georgetown, Tex.). 4(4)
The toroidal Rad9-Rad1-Hus1 checkpoint complex (9-1-1) is structurally similar to the proliferating cell nuclear antigen (PCNA), which serves as a sliding clamp platform for DNA replication and repair. 9-1-1 has been characterized as a sensor of DNA
Publikováno v:
American journal of clinical oncology. 28(1)
Cellular sensitivity to ionizing radiation (IR) treatment is a complex biologic phenomenon that is affected by several processes, namely the ability of the cell to detect and repair DNA damage, regulate cell cycle division, and execute apoptosis. Bec