Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Christopher E. Heise"'
Autor:
Dawei Sun, Kelly M. Storek, Dimitry Tegunov, Ying Yang, Christopher P. Arthur, Matthew Johnson, John G. Quinn, Weijing Liu, Guanghui Han, Hany S. Girgis, Mary Kate Alexander, Austin K. Murchison, Stephanie Shriver, Christine Tam, Hiroshi Ijiri, Hiroko Inaba, Tatsuya Sano, Hayato Yanagida, Junichi Nishikawa, Christopher E. Heise, Wayne J. Fairbrother, Man-Wah Tan, Nicholas Skelton, Wendy Sandoval, Benjamin D. Sellers, Claudio Ciferri, Peter A. Smith, Patrick C. Reid, Christian N. Cunningham, Steven T. Rutherford, Jian Payandeh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract BamA is the central component of the essential β-barrel assembly machine (BAM), a conserved multi-subunit complex that dynamically inserts and folds β-barrel proteins into the outer membrane of Gram-negative bacteria. Despite recent advanc
Externí odkaz:
https://doaj.org/article/bf48c6d78a39468c81c644c4c61faa56
Autor:
J. Hiroshi Morisaki, Peter A. Smith, Shailesh V. Date, Kimberly K. Kajihara, Chau Linda Truong, Zora Modrusan, Donghong Yan, Jing Kang, Min Xu, Ishita M. Shah, Robert Mintzer, Eric M. Kofoed, Tommy K. Cheung, David Arnott, Michael F. T. Koehler, Christopher E. Heise, Eric J. Brown, Man-Wah Tan, Wouter L. W. Hazenbos
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
ABSTRACT The type I signal peptidase of Staphylococcus aureus, SpsB, is an attractive antibacterial target because it is essential for viability and extracellularly accessible. We synthesized compound 103, a novel arylomycin-derived inhibitor of SpsB
Externí odkaz:
https://doaj.org/article/3b9f916136964f4eb118797ed067be1e
Autor:
Yuan Chen, Matthew R. Durk, Lionel Rouge, Peter A. S. Smith, Man-Wah Tan, John S. Wai, Jacob Schwarz, Tucker C. Roberts, Jing Kang, Donghong Yan, Hany S. Girgis, Summer Park, John G. Quinn, Min Xu, Prasuna Paraselli, Christopher E. Heise, Jeremy Murray, Wilson Phung, Yongsheng Chen, James J. Crawford, Robert I. Higuchi, Zhiyong Yu, Michael F. T. Koehler, Elizabeth Skippington, Hua Zhang
Publikováno v:
Nature. 561:189-194
Multidrug-resistant bacteria are spreading at alarming rates, and despite extensive efforts no new class of antibiotic with activity against Gram-negative bacteria has been approved in over fifty years. Natural products and their derivatives have a k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ec234ca5fb6e9853f7b3be3f183058
https://doi.org/10.1038/s41586-018-0483-6
https://doi.org/10.1038/s41586-018-0483-6
Autor:
Daniel J. Burdick, Lauren Goeser, Jianping Yin, Shumei Wang, John Moffat, Steven Magnuson, Weiru Wang, Jeff Blaney, Huifen Chen, Borlan Pan, Christopher E. Heise, Jake Drummond
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4728-4732
A fragment-based lead discovery approach was used to discover novel ERK2 inhibitors. The crystal structure of N-benzyl-9H-purin-6-amine 1 in complex with ERK2 elucidated its hinge-binding mode. In addition, the simultaneous binding of an imidazole mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b6f6662d3adf70ddbff4a85969d128
https://doi.org/10.1016/j.bmcl.2015.08.048
https://doi.org/10.1016/j.bmcl.2015.08.048
Autor:
Jing Kang, Robert Mintzer, Kimberly Kajihara, Wouter L. W. Hazenbos, Shailesh V. Date, Peter A. S. Smith, J. Hiroshi Morisaki, Eric M. Kofoed, Man-Wah Tan, Eric J. Brown, Tommy K. Cheung, Donghong Yan, Chau Linda Truong, David Arnott, Ishita M. Shah, Michael F. T. Koehler, Zora Modrusan, Min Xu, Christopher E. Heise
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
Microbial Cell
mBio, Vol 7, Iss 5, p e00412-16 (2016)
mBio
Microbial Cell
mBio, Vol 7, Iss 5, p e00412-16 (2016)
mBio
The type I signal peptidase of Staphylococcus aureus, SpsB, is an attractive antibacterial target because it is essential for viability and extracellularly accessible. We synthesized compound 103, a novel arylomycin-derived inhibitor of SpsB with sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65167f36ea53ca0a0bea23184838a58b
https://doi.org/10.1128/mbio.00412-16
https://doi.org/10.1128/mbio.00412-16
Autor:
Wendy Lee, Lionel Rouge, Joachim Rudolph, Sreemathy Ramaswamy, Klaus P. Hoeflich, Suzanne Tay, Lesley J. Murray, Ignacio Aliagas, Christopher E. Heise, Hank La, Weiru Wang, Robert Mintzer, James J. Crawford, Simon Mathieu
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(15)
A series of 4-azaindole-containing p21-activated kinase-1 (PAK1) inhibitors was prepared with the goal of improving physicochemical properties relative to an indole starting point. Indole 1 represented an attractive, non-basic scaffold with good PAK1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae68472ef47fb32d1b40f899b04ebe3e
https://pubmed.ncbi.nlm.nih.gov/27346791
https://pubmed.ncbi.nlm.nih.gov/27346791
Autor:
Jennifer Epler, Joachim Rudolph, Joy Drobnick, Roxanne Vega, Ignacio Aliagas, Sreemathy Ramaswamy, Elizabeth Blackwood, Klaus P. Hoeflich, Diana Jakubiak, Wendy Lee, Haiming Zhang, Xianrui Zhao, Weiru Wang, Christopher E. Heise, David Favor, Chudi Ndubaku, Thomas W. O'Brien, Gary A. Cain, Lesley J. Murray, Paroma Chakravarty, Hank La, Christy C. Ong, Ping Dong, Connie Chan, James J. Crawford, Angela Oh, Yu Zhong, Dolores Díaz, Lewis J. Gazzard
Publikováno v:
Journal of medicinal chemistry. 59(11)
p21-activated kinase 1 (PAK1) has an important role in transducing signals in several oncogenic pathways. The concept of inhibiting this kinase has garnered significant interest over the past decade, particularly for targeting cancers associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0be5f9cfb402a0bbeedbcf126e00c2a
https://pubmed.ncbi.nlm.nih.gov/27167326
https://pubmed.ncbi.nlm.nih.gov/27167326
Autor:
Amy Gustafson, Maureen Beresini, Linda O. Elliott, Robert Mintzer, Kevin R Clark, Christopher E. Heise, Cristina Lewis, Kinjalkumar Shah, Marya Liimatta, Yichin Liu, Adam R. Johnson, Stephen Schmidt
Publikováno v:
SLAS Discovery. 17:225-236
Identifying chemical lead matter by high-throughput screening (HTS) has been a common practice in early stage drug discovery. Evolution of small-molecule library composition to include more drug-like molecules with desirable physical chemical propert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ce4af0acf15b02c1b2f4e674a015c6
https://doi.org/10.1177/1087057111421525
https://doi.org/10.1177/1087057111421525
Publikováno v:
ASSAY and Drug Development Technologies. 8:497-503
The Ras, Raf, mitogen-activated protein kinase kinase (MEK) and extracellular signal-regulated kinase (ERK) signaling cascade is critically involved in cellular signaling with activating mutations in Ras and Raf present in many human tumors. Each con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2199d6bbd661eebf8a3d0ed4464f8aed
https://doi.org/10.1089/adt.2009.0259
https://doi.org/10.1089/adt.2009.0259
Autor:
Jason Haelewyn, Brian Dyck, Troy Vickers, Junko Tamiya, Mingzhu Zhang, Linh Nguyen, Martin W. Rowbottom, David A. Schwarz, Val S. Goodfellow, Monica S. Mistry, Christopher E. Heise, Jonathan Grey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2535-2539
A series of thienopyrimidinone bis-aminopyrrolidine ureas were designed, synthesized, and evaluated for their ability to bind melanin-concentrating hormone receptor-1. These compounds exhibit potent binding affinity (K(i)=3 nM) and good in vitro meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe96e12383f0fb984ce0e4f668bb4640
https://doi.org/10.1016/j.bmcl.2007.02.012
https://doi.org/10.1016/j.bmcl.2007.02.012