Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Christopher E. Hart"'
Autor:
Christine E. Cho, Sagar S. Damle, Edward V. Wancewicz, Swagatam Mukhopadhyay, Christopher E. Hart, Curt Mazur, Eric E. Swayze, Fredrik Kamme
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-16 (2019)
Abstract Background Microglia are multifunctional cells that are key players in brain development and homeostasis. Recent years have seen tremendous growth in our understanding of the role microglia play in neurodegeneration, CNS injury, and developm
Externí odkaz:
https://doaj.org/article/93988ddf97354f41be11fd97dfc4427b
Autor:
Steven Kuntz, Brett P. Monia, Sagar S. Damle, Jeff Crosby, Guizhen Sun, Tamar R. Grossman, Christopher E. Hart, Michele Carrer, Chenguang Zhao
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 63:46-56
Goblet cell metaplasia, excessive mucus production, and inadequate mucus clearance accompany and exacerbate multiple chronic respiratory disorders, such as asthma and chronic obstructive pulmonary disease. Notch signaling plays a central role in cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08cf6ec53a3352545b1aeff995632a1f
https://doi.org/10.1165/rcmb.2019-0257oc
https://doi.org/10.1165/rcmb.2019-0257oc
Autor:
Laurence Mignon, Kim Doan, Michael Murphy, Lauren Elder, Chris Yun, Jeff Milton, Shruti Sasaki, Christopher E. Hart, Dante Montenegro, Nickolas Allen, Dany Matar, Danielle Ciofani, Frank Rigo, Leonardo Sahelijo
Publikováno v:
Contemporary clinical trials. 119
Pharmaceutical drug development rarely addresses a study participant's control of their genomic data, how to return individual incidental findings, and how to make use of genomic data more efficiently for exploratory research purposes. Mutually benef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d64c07f66f7fb0ece5b5c09cfad8688
https://pubmed.ncbi.nlm.nih.gov/35691489
https://pubmed.ncbi.nlm.nih.gov/35691489
Autor:
Lulu Huang, Sagar S Damle, Sheri Booten, Priyam Singh, Mahyar Sabripour, Jeff Hsu, Minji Jo, Melanie Katz, Andy Watt, Christopher E Hart, Susan M Freier, Brett P Monia, Shuling Guo
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132798 (2015)
Liver regeneration after partial hepatectomy (PHx) is a complex and well-orchestrated biological process in which synchronized cell proliferation is induced in response to the loss of liver mass. To define long noncoding RNAs (lncRNAs) that participa
Externí odkaz:
https://doaj.org/article/6cb40089f7c54364ba90740f1b4158a0
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 12, p e169 (2006)
A current challenge is to develop computational approaches to infer gene network regulatory relationships based on multiple types of large-scale functional genomic data. We find that single-layer feed-forward artificial neural network (ANN) models ca
Externí odkaz:
https://doaj.org/article/151f6f704e2f4aaba6962d495e3d48e3
Autor:
Edward Wancewicz, Eric E. Swayze, Fredrik Kamme, Curt Mazur, Sagar S. Damle, Christopher E. Hart, Swagatam Mukhopadhyay, Christine E. Cho
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-16 (2019)
BMC Genomics
BMC Genomics
Background Microglia are multifunctional cells that are key players in brain development and homeostasis. Recent years have seen tremendous growth in our understanding of the role microglia play in neurodegeneration, CNS injury, and developmental dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00149721ba12173cbf97b81a3fe186a0
https://doi.org/10.1186/s12864-019-5549-9
https://doi.org/10.1186/s12864-019-5549-9
Autor:
Husam S. Younis, Christopher E. Hart, Shuting Xia, T Jesse Kwoh, Huynh-Hoa Bui, Scott P. Henry, Sanjay Bhanot, Brenda F. Baker, Sebastien A. Burel, Dan J Schulz, Wei Cheng, Nelson Salgado, Richard S. Geary, Stanley T. Crooke
Publikováno v:
Molecular Therapy
The common chemical and biological properties of antisense oligonucleotides provide the opportunity to identify and characterize chemical class effects across species. The chemical class that has proven to be the most versatile and best characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11958b0f8e7b0ee570f85fd93afc6c43
https://doi.org/10.1038/mt.2016.136
https://doi.org/10.1038/mt.2016.136
Autor:
Christopher E. Hart, Rosanne M. Crooke, Thomas A. Bell, Stan Riney, Stanley T. Crooke, Cheryl L De Hoyos, Xue-hai Liang, Hong Sun, Audrey Low, Melanie Bell, Punit P. Seth, Timothy A. Vickers, Meghdad Rahdar, Sarah Greenlee, Michael T. Migawa, Wen Shen, Susan F. Murray, Swagatam Mukhopadhyay
Publikováno v:
Nature biotechnology. 37(6)
The molecular mechanisms of toxicity of chemically modified phosphorothioate antisense oligonucleotides (PS-ASOs) are not fully understood. Here, we report that toxic gapmer PS-ASOs containing modifications such as constrained ethyl (cEt), locked nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30d3ba06eaba3b19cc16ad4defa320b
https://pubmed.ncbi.nlm.nih.gov/31036929
https://pubmed.ncbi.nlm.nih.gov/31036929
Autor:
Eric E. Swayze, Jeff Milton, Christopher E. Hart, Tianhong Zhang, Sabrina Hecht, Claire Bellamy, Sergio Rotstein, Markus Weisser
Publikováno v:
Journal of chemical information and modeling. 57(6)
Hierarchical Editing Language for Macromolecules (HELM version 2.0) is a molecular line notation similar to SMILEs but specifically for communicating and managing biopolymer structures. The HELM project, part of the Pistoia Alliance nonprofit organiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f338c10e0404a0d01b5d5c27a7947ac5
https://pubmed.ncbi.nlm.nih.gov/28471655
https://pubmed.ncbi.nlm.nih.gov/28471655
Autor:
Guillermo Vasquez, Heather M. Murray, Walt F. Lima, Andres Berdeja, Eric E. Swayze, W. Brad Wan, Hans Gaus, Josh G. Nichols, Punit P. Seth, Christopher E. Hart, Michael T. Migawa, Sam Lee
Publikováno v:
Nucleic Acids Research
Bicyclic oxazaphospholidine monomers were used to prepare a series of phosphorothioate (PS)-modified gapmer antisense oligonucleotides (ASOs) with control of the chirality of each of the PS linkages within the 10-base gap. The stereoselectivity was d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b998d608d82c2dde1115aee2213c2418
https://doi.org/10.1093/nar/gku1115
https://doi.org/10.1093/nar/gku1115