Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Christopher E. Coletta"'
Autor:
Victor A. Maltsev, Magdalena Juhaszova, Michael D. Stern, Kenta Tsutsui, Rostislav Bychkov, Edward G. Lakatta, Christopher E. Coletta
Publikováno v:
JACC: Clinical Electrophysiology. 6:907-931
Objectives This study sought to identify subcellular Ca2+ signals within and among cells comprising the sinoatrial node (SAN) tissue. Background The current paradigm of SAN impulse generation: 1) is that full-scale action potentials (APs) of a common
Autor:
Christopher E. Coletta, Myriam Gorospe, Supriyo De, Madhav Thambisetty, Krystyna Mazan-Mamczarz, Kirtana Veeraraghavan, Gautam Kundu, Kyle Ruxton Cochran
Publikováno v:
Genes, Vol 12, Iss 1258, p 1258 (2021)
Genes
Volume 12
Issue 8
Genes
Volume 12
Issue 8
Mammalian circRNAs are covalently closed circular RNAs often generated through backsplicing of precursor linear RNAs. Although their functions are largely unknown, they have been found to influence gene expression at different levels and in a wide ra
Autor:
Sören Boller, Tonya Wallace, Christopher E. Coletta, Dimitra Sarantopoulou, Julia McKelvey, Yulan Piao, Luigi Ferrucci, Cuong Q. Nguyen, Sampath Arepalli, Benjamin D. Shapiro, Christopher A. Dunn, Mary Kaileh, Ranjan Sen, Dena G. Hernandez, Linda Zukley, Nan-ping Weng, Arsun Bektas, Alexis Battle, Roshni Roy, Ann Zenobia Moore, Senthilkumar Ramamoorthy, Supriyo De, Toshiko Tanaka, Kevin G. Becker, Rudolf Grosschedl, Amit Singh, William H. Wood, Jaekwan Kim, Jyoti Misra Sen, Robert P. Wersto
Publikováno v:
Immunity
Epigenetic reprogramming underlies specification of immune cell lineages, but patterns that uniquely define immune cell types and the mechanisms by which they are established remain unclear. Here, we identified lineage-specific DNA methylation signat
Autor:
Jun Ding, Christopher E. Coletta, Alexey E. Lyashkov, Jen-Hao Yang, Mary Kaileh, Abhinav Harish, Supriyo De, Ceereena Ubaida-Mohien, Luigi Ferrucci, William H. Wood, Robert A. Tumasian, Ranjan Sen, Chee W. Chia, Yulan Piao, Marta Gonzalez-Freire, Linda Zukley, Myriam Gorospe, Gautam Kundu
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve tissue integrity. To characterize these changes, RNA was extracted and sequenced from muscle b
Autor:
Magdalena Juhaszova, Victor A. Maltsev, Edward G. Lakatta, Christopher E. Coletta, Rostislav Bychkov, Michael D. Stern, Kenta Tsutsui
BackgroundThe current paradigm of Sinoatrial Node (SAN) impulse generation: (i) is that full-scale action potentials (APs) of a common frequency are initiated at one site and are conducted within the SAN along smooth isochrones; and (ii) does not fea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8d9cf986a10a233043ecbacd3a055e
https://doi.org/10.1101/2020.04.14.039461
https://doi.org/10.1101/2020.04.14.039461
Autor:
Mustapha Bouhrara, Ping Chang Lin, Benoit Lehallier, Christopher E. Coletta, Kenneth L. Urish, Beth G. Ashinsky, Ilya G. Goldberg, Richard G. Spencer
Publikováno v:
Journal of Orthopaedic Research. 35:2243-2250
The purpose of this study is to evaluate the ability of a machine learning algorithm to classify in vivo magnetic resonance images (MRI) of human articular cartilage for development of osteoarthritis (OA). Sixty-eight subjects were selected from the
Autor:
Christopher E. Coletta, Kevin G. Becker, D. Mark Eckley, Nikita Orlov, Ilya G. Goldberg, Paul Bastian, Elin Lehrmann, Yonqing Zhang, Mark A. Wilson, Wendy B. Iser
In this study, we describe a morphological biomarker that detects multiple discrete subpopulations (or "age-states") at several chronological ages in a population of nematodes (Caenorhabditis elegans). We determined the frequencies of three healthy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b897810821b941a1b6f8b065cd387b
https://europepmc.org/articles/PMC6001903/
https://europepmc.org/articles/PMC6001903/
Autor:
Mustapha Bouhrara, Vanessa A. Lukas, Corey P. Neu, Julianne M. Boyle, Ilya G. Goldberg, Richard G. Spencer, David A. Reiter, Beth G. Ashinsky, Christopher E. Coletta
Publikováno v:
Osteoarthritis and Cartilage. 23:1704-1712
Summary Objective The purpose of this study is to evaluate the ability of machine learning to discriminate between magnetic resonance images (MRI) of normal and pathological human articular cartilage obtained under standard clinical conditions. Metho
Autor:
Yuhki Nakatake, C Chen, David Mark Eckley, Christopher E. Coletta, John D. Delaney, Nikita Orlov, Ilya G. Goldberg
Bio-image informatics is the systematic application of image analysis algorithms to large image datasets to provide an objective method for accurately and consistently scoring image data. Within this field, pattern recognition (PR) is a form of super
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa8d400ac4f42149a02011d866f020a
https://doi.org/10.1101/097329
https://doi.org/10.1101/097329
Autor:
Michela Gallagher, Christopher E. Coletta, Evelyn V. Perez, Peter R. Rapp, Inês Tomás Pereira, Ilya G. Goldberg, David H. Kim
Publikováno v:
Neurobiology of Aging. 34:832-844
Normal cognitive aging is associated with deficits in memory processes dependent on the hippocampus, along with large-scale changes in the hippocampal expression of many genes. Histone acetylation can broadly influence gene expression and has been re