Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Christopher E Turner"'
Autor:
Megan E Brasch, Giuseppe Passucci, Anushree C Gulvady, Christopher E Turner, M Lisa Manning, James H Henderson
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211408 (2019)
Cell motility is critical to biological processes from wound healing to cancer metastasis to embryonic development. The involvement of organelles in cell motility is well established, but the role of organelle positional reorganization in cell motili
Externí odkaz:
https://doaj.org/article/7a6d0aee5b9a4e8a9029da4fe5934192
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0165266 (2016)
BACKGROUND:Paxillin family proteins regulate intracellular signaling downstream of extracellular matrix adhesion. Tissue expression patterns and cellular functions of Paxillin proteins during embryo development remain poorly understood. Additionally,
Externí odkaz:
https://doaj.org/article/62a0c05433a24274800b3b8dcc5b05eb
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91815 (2014)
Motile cells are capable of sensing the stiffness of the surrounding extracellular matrix through integrin-mediated focal adhesions and migrate towards regions of higher rigidity in a process known as durotaxis. Durotaxis plays an important role in n
Externí odkaz:
https://doaj.org/article/f62dc6c97b60473e96a1d0496e88fca0
Autor:
Mark A Smith, Elizabeth Blankman, Nicholas O Deakin, Laura M Hoffman, Christopher C Jensen, Christopher E Turner, Mary C Beckerle
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e69378 (2013)
Contractile actomyosin stress fibers are critical for maintaining the force balance between the interior of the cell and its environment. Consequently, the actin cytoskeleton undergoes dynamic mechanical loading. This results in spontaneous, stochast
Externí odkaz:
https://doaj.org/article/36258c244ec34ebea41f4a2205c889b9
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37990 (2012)
Cell migration is of paramount importance to organism development and maintenance as well as multiple pathological processes, including cancer metastasis. The RhoGTPases Rac1 and RhoA are indispensable for cell migration as they regulate cell protrus
Externí odkaz:
https://doaj.org/article/77b7334b20a249bf922a3f5d0780a647
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46228 (2012)
Cell adhesion to the extracellular matrix is a key event in cell migration and invasion and endocytic trafficking of adhesion receptors and signaling proteins plays a major role in regulating these processes. Beta2-adaptin is a subunit of the AP-2 co
Externí odkaz:
https://doaj.org/article/39e221ee9ac34f4bb77c27ee21fafb6a
Publikováno v:
Molecular Biology of the Cell. 34
The role of the focal adhesion adaptor paxillin in regulating the Rab5 GTPase is evaluated. Paxillin, through modulation of HDAC6 activity and thereby microtubule acetylation, was shown to regulate Rab5 activity, as well as Rab5-associated vesicle di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4ebcdbe5da5f6035d2184f500c94c64
https://doi.org/10.1091/mbc.e22-10-0455
https://doi.org/10.1091/mbc.e22-10-0455
Much of our understanding of the pathology of acute leukemias is based on studies of 11q23 chromosomal translocations of the gene encoding the mixed lineage leukemia-1 (MLL1) histone H3 lysine 4 (H3K4) methyltransferase. Translocations of the MLL1 ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d38261f8a1e05866e3bb0c5613056e76
https://doi.org/10.1101/2022.12.16.520790
https://doi.org/10.1101/2022.12.16.520790
Publikováno v:
Molecular biology of the cell. 33(2)
Distant organ metastasis is linked to poor prognosis during cancer progression. The expression level of the focal adhesion adapter protein paxillin varies among different human cancers, but its role in tumor progression is unclear. Herein we utilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900a842d817ddad9d2d46e1917a6b4ea
https://pubmed.ncbi.nlm.nih.gov/34851720
https://pubmed.ncbi.nlm.nih.gov/34851720
Publikováno v:
Molecular Biology of the Cell
Fibroblasts transformed by the proto-oncogene Src form individual invadopodia that can spontaneously self-organize into large matrix-degrading superstructures called rosettes. However, the mechanisms by which the invadopodia can spatiotemporally reor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091f2fecdb0335c109d8345586539895
http://europepmc.org/articles/PMC6724605
http://europepmc.org/articles/PMC6724605