Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Christopher E Ellison"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
In this study, Lawlor et al. show that transposons on the Drosophila Y chromosome have evolved to exploit a specific stage of spermatogenesis when the Y chromosome is decondensed and the piRNA pathway is downregulated.
Externí odkaz:
https://doaj.org/article/72ab06ffa6cc4e3ab7400089bbc1f300
Autor:
Lei Chen, Shirley Luo, Abigail Dupre, Roshan P. Vasoya, Aditya Parthasarathy, Rohit Aita, Raj Malhotra, Joseph Hur, Natalie H. Toke, Eric Chiles, Min Yang, Weihuan Cao, Juan Flores, Christopher E. Ellison, Nan Gao, Amrik Sahota, Xiaoyang Su, Edward M. Bonder, Michael P. Verzi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Brush border gene regulation in various different tissues is incompletely understood. Here, the authors show HNF4 regulates the brush border gene program in multiple organs, such as intestine, kidney and yolk sac, and also intestinal chromatin loopin
Externí odkaz:
https://doaj.org/article/5b2c764533374b2391e6fb24a9437a11
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010268 (2022)
R-loops are three-stranded nucleotide structures consisting of a DNA:RNA hybrid and a displaced ssDNA non-template strand. Previous work suggests that R-loop formation is primarily determined by the thermodynamics of DNA:RNA binding, which are govern
Externí odkaz:
https://doaj.org/article/187094dd0a304f41893b95ea3c716656
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 6, Pp 1893-1900 (2019)
N6-methyladenine (6mA or m6dA) is a DNA modification that has long been known to play an important role in a variety of biological functions in prokaryotes. This modification has only recently been described in eukaryotes, where it seems to have evol
Externí odkaz:
https://doaj.org/article/1de54e0734ad49c6a82fdd52541d0cef
Publikováno v:
PLoS Genetics, Vol 16, Iss 12, p e1009229 (2020)
Topologically associating domains, or TADs, are functional units that organize chromosomes into 3D structures of interacting chromatin. TADs play an important role in regulating gene expression by constraining enhancer-promoter contacts and there is
Externí odkaz:
https://doaj.org/article/7744f5f32f324fbbb3d49a28fd935424
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3000689 (2020)
Coevolution between transposable elements (TEs) and their hosts can be antagonistic, where TEs evolve to avoid silencing and the host responds by reestablishing TE suppression, or mutualistic, where TEs are co-opted to benefit their host. The TART-A
Externí odkaz:
https://doaj.org/article/ee5cf49cb66647c29b3621b92ae65864
Autor:
Wilson Leung, Nicole Torosin, Weihuan Cao, Laura K Reed, Cindy Arrigo, C R Sarah Elgin, Christopher E Ellison
Publikováno v:
bioRxiv
Flow cytometry estimates of genome sizes among species ofDrosophilashow a 3-fold variation, ranging from ∼127 Mb inDrosophila mercatorumto ∼400 Mb inDrosophila cyrtoloma. However, the assembled portion of the Muller F Element (orthologous to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f646c3f07f4c38968429d55efb069b9
https://doi.org/10.1101/2023.05.22.541758
https://doi.org/10.1101/2023.05.22.541758
Transposable elements (TEs) are selfish DNA sequences that can replicate themselves in their host's genome. Hosts have evolved specialized strategies for mitigating the deleterious consequences of TE activity. In Drosophila, the piRNA pathway is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6ba7750cf3ddea8ef4d8d710dd99317
https://doi.org/10.31219/osf.io/btvmh
https://doi.org/10.31219/osf.io/btvmh
Publikováno v:
Molecular Biology and Evolution. 39
Topologically associating domains (TADs) are thought to play an important role in preventing gene misexpression by spatially constraining enhancer–promoter contacts. The deleterious nature of gene misexpression implies that TADs should, therefore,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572f3a61d13a9b303437a5b33466bba1
https://doi.org/10.1093/molbev/msac216
https://doi.org/10.1093/molbev/msac216
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Transposable elements (TEs) must replicate in germline cells to pass novel insertions to offspring. In Drosophila melanogaster ovaries, TEs can exploit specific developmental windows of opportunity to evade host silencing and increase their copy numb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b507dbbe3d6accc83bbc50be2fc7ae6a
http://europepmc.org/articles/PMC8617248
http://europepmc.org/articles/PMC8617248