Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Christopher E Barbieri"'
Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate
Autor:
Xuanrong Chen, Michael A. Augello, Deli Liu, Kevin Lin, Alex Hakansson, Martin Sjöström, Francesca Khani, Lesa D. Deonarine, Yang Liu, Jaida Travascio-Green, Jiansheng Wu, Un In Chan, Jude Owiredu, Massimo Loda, Felix Y. Feng, Brian D. Robinson, Elai Davicioni, Andrea Sboner, Christopher E. Barbieri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The androgen receptor (AR) is central in prostate tissue identity and differentiation, and controls normal growth-suppressive, prostate-specific gene expression. It also drives prostate tumorigenesis when hijacked for oncogenic transcription
Externí odkaz:
https://doaj.org/article/07a68e6011a946bc9d120ecc4b67fc67
Autor:
Jonathan Shoag, Christopher E Barbieri
Publikováno v:
Asian Journal of Andrology, Vol 18, Iss 4, Pp 543-548 (2016)
Prostate cancer is a clinically heterogeneous disease, with some men having indolent disease that can safely be observed, while others have aggressive, lethal disease. Over the past decade, researchers have begun to unravel some of the genomic hetero
Externí odkaz:
https://doaj.org/article/5b4c98659eae49c388f002b07f7dc041
Autor:
Gunther Boysen, Christopher E Barbieri, Davide Prandi, Mirjam Blattner, Sung-Suk Chae, Arun Dahija, Srilakshmi Nataraj, Dennis Huang, Clarisse Marotz, Limei Xu, Julie Huang, Paola Lecca, Sagar Chhangawala, Deli Liu, Pengbo Zhou, Andrea Sboner, Johann S de Bono, Francesca Demichelis, Yariv Houvras, Mark A Rubin
Publikováno v:
eLife, Vol 4 (2015)
Genomic instability is a fundamental feature of human cancer often resulting from impaired genome maintenance. In prostate cancer, structural genomic rearrangements are a common mechanism driving tumorigenesis. However, somatic alterations predisposi
Externí odkaz:
https://doaj.org/article/0df5ad7823f54624b0abe66f26705258
Autor:
Hubert Pakula, Mohamed Omar, Ryan Carelli, Filippo Pederzoli, Giuseppe Nicolò Fanelli, Tania Pannellini, Fabio Socciarelli, Lucie Van Emmenis, Silvia Rodrigues, Caroline Fidalgo-Ribeiro, Pier Vitale Nuzzo, Nicholas J. Brady, Wikum Dinalankara, Madhavi Jere, Itzel Valencia, Christopher Saladino, Jason Stone, Caitlin Unkenholz, Richard Garner, Mohammad K. Alexanderani, Francesca Khani, Francisca Nunes de Almeida, Cory Abate-Shen, Matthew B. Greenblatt, David S. Rickman, Christopher E. Barbieri, Brian D. Robinson, Luigi Marchionni, Massimo Loda
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract In the complex tumor microenvironment (TME), mesenchymal cells are key players, yet their specific roles in prostate cancer (PCa) progression remain to be fully deciphered. This study employs single-cell RNA sequencing to delineate molecular
Externí odkaz:
https://doaj.org/article/f358a6f85a6c4b2189686dbb0cfa358f
Autor:
Elisa Benedetti, Kelsey Chetnik, Thomas Flynn, Christopher E. Barbieri, Douglas S. Scherr, Massimo Loda, Jan Krumsiek
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-8 (2023)
Abstract Prostate cancer is the second most common cancer in men and affects 1 in 9 men in the United States. Early screening for prostate cancer often involves monitoring levels of prostate-specific antigen (PSA) and performing digital rectal exams.
Externí odkaz:
https://doaj.org/article/d0a20e13995d4a0ca46dac4e068bf0ec
Autor:
Ariel E. Marciscano, Sydney Wolfe, Xi Kathy Zhou, Christopher E. Barbieri, Silvia C. Formenti, Jim C. Hu, Ana M. Molina, David M. Nanus, Jones T. Nauseef, Douglas S. Scherr, Cora N. Sternberg, Scott T. Tagawa, Himanshu Nagar
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background Ultra-hypofractionated image-guided stereotactic body radiotherapy (SBRT) is increasingly used for definitive treatment of localized prostate cancer. Magnetic resonance imaging-guided radiotherapy (MRgRT) facilitates improved visu
Externí odkaz:
https://doaj.org/article/fa243c6550cd4849bd0e24f9ff480799
Autor:
Chandrani Mukhopadhyay, Chenyi Yang, Limei Xu, Deli Liu, Yu Wang, Dennis Huang, Lesa Dayal Deonarine, Joanna Cyrta, Elai Davicioni, Andrea Sboner, Brian. D. Robinson, Arul M. Chinnaiyan, Mark A. Rubin, Christopher E. Barbieri, Pengbo Zhou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
SPOP functions as a tumour suppressor in prostate cancer but how the protein is regulated is unclear. Here, the authors identify G3BP1 as a competitive inhibitor of SPOP and show that G3BP1-SPOP axis activates androgen signalling to drive tumorigenes
Externí odkaz:
https://doaj.org/article/3fedf5b03c0240298b8eebd7424bc58a
Autor:
Salma Ben-Salem, Qiang Hu, Yang Liu, Mohammed Alshalalfa, Xin Zhao, Irene Wang, Varadha Balaji Venkadakrishnan, Dhirodatta Senapati, Sangeeta Kumari, Deli Liu, Andrea Sboner, Christopher E. Barbieri, Felix Feng, Jean-Noel Billaud, Elai Davicioni, Song Liu, Hannelore V. Heemers
Publikováno v:
European Urology Open Science, Vol 22, Iss , Pp 34-44 (2020)
Background: Metastatic prostate cancer (CaP) treatments are evolving rapidly but without evidence-based biomarkers to predict responses, and to maximize remissions and survival. Objective: To determine the activity of androgen receptor (AR), the targ
Externí odkaz:
https://doaj.org/article/ba587ec25e6b4c92b3f6ddb1ad16913f
Autor:
Deli Liu, Jonathan E. Shoag, Daniel Poliak, Ramy S. Goueli, Vaishali Ravikumar, David Redmond, Aram Vosoughi, Jacqueline Fontugne, Heng Pan, Daniel Lee, Domonique Thomas, Keyan Salari, Zongwei Wang, Alessandro Romanel, Alexis Te, Richard Lee, Bilal Chughtai, Aria F. Olumi, Juan Miguel Mosquera, Francesca Demichelis, Olivier Elemento, Mark A. Rubin, Andrea Sboner, Christopher E. Barbieri
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Benign prostatic hyperplasia (BPH) is one of the most common diseases affecting aging men with limited therapeutic options. In this study, the authors describe the molecular characterization of BPH performing genomic, transcriptomic and epigenetic an
Externí odkaz:
https://doaj.org/article/e8baf4a938944f0fbc66a64df0469d3e
Autor:
Jacqueline Fontugne, Peter Y. Cai, Hussein Alnajar, Bhavneet Bhinder, Kyung Park, Huihui Ye, Shaham Beg, Verena Sailer, Javed Siddiqui, Mirjam Blattner-Johnson, Jaclyn A. Croyle, Zohal Noorzad, Carla Calagua, Theresa Y. MacDonald, Ulrika Axcrona, Mari Bogaard, Karol Axcrona, Douglas S. Scherr, Martin G. Sanda, Bjarne Johannessen, Arul M. Chinnaiyan, Olivier Elemento, Rolf I. Skotheim, Mark A. Rubin, Christopher E. Barbieri, Juan Miguel Mosquera
Publikováno v:
JCI Insight, Vol 7, Iss 4 (2022)
BACKGROUND Prostate cancer is multifocal with distinct molecular subtypes. The utility of genomic subtyping has been challenged due to inter- and intrafocal heterogeneity. We sought to characterize the subtype-defining molecular alterations of primar
Externí odkaz:
https://doaj.org/article/c79b0c37b3564a8a9e8aad713f06f212