Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Christopher E, Nelson"'
Autor:
Gulab Rangani, Ana Claudia Langaro, Shilpi Agrawal, Reiofeli A. Salas-Perez, Juan Camilo Velásquez, Christopher E. Nelson, Nilda Roma-Burgos
Publikováno v:
Agronomy, Vol 14, Iss 10, p 2316 (2024)
Italian ryegrass (Lolium multiflorum Lam.) is a persistent weed species that poses significant management challenges in key agricultural crops such as wheat, corn, cotton, and soybean. This study investigated the prevalence of resistance to ACCase in
Externí odkaz:
https://doaj.org/article/7b5c9d73d1084405b9f380dc0ab79039
Autor:
Shilpi Agrawal, Made Harumi Padmaswari, Abbey L. Stokes, Daniel Maxenberger, Morgan Reese, Adila Khalil, Christopher E. Nelson
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1226 (2024)
The CRISPR-Cas9 system is a revolutionary tool in genetic engineering, offering unprecedented precision and efficiency in genome editing. Cas9, an enzyme derived from bacteria, is guided by RNA to edit DNA sequences within cells precisely. However, w
Externí odkaz:
https://doaj.org/article/2f2c2d43055c4acc9c6058f06ddb984c
Autor:
Mary S. Jia, Christopher E. Nelson
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 908-909 (2023)
Externí odkaz:
https://doaj.org/article/cb62c236a0e54508b0d611f2beca2023
Autor:
Chady H. Hakim, Sandeep R. P. Kumar, Dennis O. Pérez-López, Nalinda B. Wasala, Dong Zhang, Yongping Yue, James Teixeira, Xiufang Pan, Keqing Zhang, Emily D. Million, Christopher E. Nelson, Samantha Metzger, Jin Han, Jacqueline A. Louderman, Florian Schmidt, Feng Feng, Dirk Grimm, Bruce F. Smith, Gang Yao, N. Nora Yang, Charles A. Gersbach, Shi-jie Chen, Roland W. Herzog, Dongsheng Duan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The Cas9-specific T cell response has been speculated to impair CRISPR therapy. Here, the authors show that local and systemic AAV CRISPR therapy induces cytotoxic killing and eliminates rescued dystrophin in canine models of Duchenne muscular dystro
Externí odkaz:
https://doaj.org/article/fa789cec57864e868cf64db8cae359c5
Autor:
Ariel I. Mundo, Abdussaboor Muhammad, Kerlin Balza, Christopher E. Nelson, Timothy J. Muldoon
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 32, Iss , Pp 100825- (2022)
Metronomic chemotherapy (MET) has been developed to address the shortcomings of maximum-tolerated chemotherapy (MTD) in regard to toxicity and development of resistance mechanisms in the tumor. In colorectal cancer (CRC), MET is a promising novel str
Externí odkaz:
https://doaj.org/article/c7e5fc936ba542419027c5a2f6945212
Autor:
Pratiksha I. Thakore, Jennifer B. Kwon, Christopher E. Nelson, Douglas C. Rouse, Matthew P. Gemberling, Matthew L. Oliver, Charles A. Gersbach
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Repression of gene transcription using CRISPR-Cas9 has been achieved in vitro but not for delivery into adult animal models. Here, the authors use AAV8 to deliver the transcriptional repressor dSaCas9KRAB to the cholesterol regulator Pcsk9, and show
Externí odkaz:
https://doaj.org/article/46f1559feeb54a51902bab3a11b455bc
Autor:
Jianguo Huang, Mark Chen, Melodi Javid Whitley, Hsuan-Cheng Kuo, Eric S. Xu, Andrea Walens, Yvonne M. Mowery, David Van Mater, William C. Eward, Diana M. Cardona, Lixia Luo, Yan Ma, Omar M. Lopez, Christopher E. Nelson, Jacqueline N. Robinson-Hamm, Anupama Reddy, Sandeep S. Dave, Charles A. Gersbach, Rebecca D. Dodd, David G. Kirsch
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Site-specific recombination and CRISPR-Cas9 have been used to generate genetically engineered mouse models of cancer. Here the authors compare sarcomas generated using both systems and see similar genetic and cellular phenotypes, suggesting CRISPR-Ca
Externí odkaz:
https://doaj.org/article/43b8c0058e5a4216b4fb7dadf1a3b419
Autor:
Made Harumi Padmaswari, Shilpi Agrawal, Mary S. Jia, Allie Ivy, Daniel A. Maxenberger, Landon A. Burcham, Christopher E. Nelson
Publikováno v:
Biophysics Reviews. 4:011307
Duchene muscular dystrophy (DMD) is an X-linked neuromuscular disorder that affects about one in every 5000 live male births. DMD is caused by mutations in the gene that codes for dystrophin, which is required for muscle membrane stabilization. The l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f611e1cd8a8d7c61ef4758fabf9019aa
https://doi.org/10.1063/5.0131452
https://doi.org/10.1063/5.0131452
Autor:
Madeleine J. Sitton, Charles A. Gersbach, Luke C. Bartelt, Chase L. Beisel, Mae M. Lewis, Kylie A. Gilcrest, Tyler S. Klann, Adrian Pickar-Oliver, Rodolphe Barrangou, Joshua B. Black, Christopher E. Nelson, Alejandro Barrera, Kevin J. Mutchnick, Timothy E. Reddy
Publikováno v:
Nature biotechnology
Class 2 CRISPR-Cas systems, such as Cas9 and Cas12, have been widely used to target DNA sequences in eukaryotic genomes. However, class 1 CRISPR-Cas systems, which represent about 90% of all CRISPR systems in nature, remain largely unexplored for gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12dde971f84f74d0b28d242dc7e1032
https://doi.org/10.1038/s41587-019-0235-7
https://doi.org/10.1038/s41587-019-0235-7
Autor:
Sue Hyun Lee, Leon M. Bellan, Mukesh Kumar Gupta, Spencer W. Crowder, Craig L. Duvall, Hak-Joon Sung, Lucas H. Hofmeister, Xintong Wang, Christopher E. Nelson
Publikováno v:
Journal of materials chemistry. B. 3(36)
Gene therapy is a promising method for the treatment of vascular disease; however, successful strategies depend on the development of safe and effective delivery technologies with specific targeting to a diseased point of vasculature. Reactive oxygen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04371d716af49a5adfaa6e5c46889891
https://pubmed.ncbi.nlm.nih.gov/32262835
https://pubmed.ncbi.nlm.nih.gov/32262835