Repeated dose multi-drug testing using a microfluidic chip-based coculture of human liver and kidney proximal tubules equivalents

Autor: Ming Xue, Juliane Hübner, Uwe Marx, Yingli Zhang, Bo Li, Xiaobing Zhou, Zuogang Li, Ni Lin, Christopher Drewell, Xingchao Geng

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)

A microfluidic multi-organ chip emulates the tissue culture microenvironment, enables interconnection of organ equivalents and overcomes interspecies differences, making this technology a promising and powerful tool for preclinical drug screening. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabb5a546ceb6ebbd244cc0d0afbb55c
http://europepmc.org/articles/PMC7264205

Towards an autologous iPSC-derived patient-on-a-chip

Autor: Anja Patricia Ramme, Uwe Marx, Alexandra Vladetic, Grace-Chiaen Lin, Christine Schwenk, Roland Lauster, Kerstin Schirrmann, Leopold Koenig, Christopher Drewell, Anna-Catharina Krebs, Winfried Neuhaus, Stephan Pabinger, Tobias Hasenberg, Corinna Magauer, Eva-Maria Dehne, Frédéric Y. Bois, Alexandra Lorenz, Daniel Faust

Microphysiological systems are fundamental for progressing towards a global paradigm shift in drug development through the generation of patient-on-a-chip models. An increasing number of single- and multi-organ systems have been adopted by the pharma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43bce61eea3cc72e40489784072de53
https://doi.org/10.1101/376970

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

Autor: Uwe Marx, Alexandra Lorenz, Juliane Hübner, Ilka Maschmeyer, Tobias Hasenberg, Roland Lauster, Anja Patricia Ramme, Katharina Schimek, Naomia Sisoli Sambo, Christopher Drewell, Sophie Bauer, Alexander Thomas, Frank Sonntag, Marcus Lindner

Systemic absorption and metabolism of drugs in the small intestine, metabolism by the liver as well as excretion by the kidney are key determinants of efficacy and safety for therapeutic candidates. However, these systemic responses of applied substa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb717f67e7709903aa80597d02b5fd83

Autologous induced pluripotent stem cell-derived four-organ-chip

Autor: Corinna Magauer, Winfried Neuhaus, Christine Schwenk, Eva-Maria Dehne, Uwe Marx, Daniel Faust, Leopold Koenig, Anja Patricia Ramme, Alexandra Vladetic, Kerstin Schirrmann, Stephan Pabinger, Tobias Hasenberg, Anna-Catharina Krebs, Frédéric Y. Bois, Roland Lauster, Grace-Chiaen Lin, Alexandra Lorenz, Christopher Drewell

Publikováno v: Future Science OA
Future Science OA, 2019, pp.art. FSO413. ⟨10.2144/fsoa-2019-0065⟩
Ramme, A P, Koenig, L, Hasenberg, T, Schwenk, C, Magauer, C, Faust, D, Lorenz, A K, Krebs, A-C, Drewell, C, Schirrmann, K, Vladetic, A, Lin, G-C, Pabinger, S, Neuhaus, W, Bois, F, Lauster, R, Marx, U & Dehne, E-M 2019, ' Autologous induced pluripotent stem cell-derived four-organ-chip ', Future science OA, vol. 5, no. 8, pp. FSO413 . https://doi.org/10.2144/fsoa-2019-0065

Microphysiological systems play a pivotal role in progressing toward a global paradigm shift in drug development. Here, we designed a four-organ-chip interconnecting miniaturized human intestine, liver, brain and kidney equivalents. All four organ mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8cfb17049640e6920ec105cdf8d3bd