Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Christopher Dravis"'
Publikováno v:
npj Breast Cancer, Vol 3, Iss 1, Pp 1-11 (2017)
Stem cells: protein not needed for stem cell activity in mammary gland A protein considered necessary for mammary stem cell activity turns out to be dispensable. What’s more, it’s not required for tumor development either. Geoffrey Wahl, Christy
Externí odkaz:
https://doaj.org/article/783e12b271884b9b9b78b908f152ebbb
Autor:
Chi-Yeh Chung, Zhibo Ma, Christopher Dravis, Sebastian Preissl, Olivier Poirion, Gidsela Luna, Xiaomeng Hou, Rajshekhar R. Giraddi, Bing Ren, Geoffrey M. Wahl
Publikováno v:
Cell Reports, Vol 29, Iss 2, Pp 495-510.e6 (2019)
Summary: Technological improvements enable single-cell epigenetic analyses of organ development. We reasoned that high-resolution single-cell chromatin accessibility mapping would provide needed insight into the epigenetic reprogramming and transcrip
Externí odkaz:
https://doaj.org/article/78432d3017414d8793a92edd0f5cd258
Autor:
Rajshekhar R. Giraddi, Chi-Yeh Chung, Richard E. Heinz, Ozlen Balcioglu, Mark Novotny, Christy L. Trejo, Christopher Dravis, Berhane M. Hagos, Elnaz Mirzaei Mehrabad, Luo Wei Rodewald, Jae Y. Hwang, Cheng Fan, Roger Lasken, Katherine E. Varley, Charles M. Perou, Geoffrey M. Wahl, Benjamin T. Spike
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1653-1666.e7 (2018)
Summary: The mammary gland consists of cells with gene expression patterns reflecting their cellular origins, function, and spatiotemporal context. However, knowledge of developmental kinetics and mechanisms of lineage specification is lacking. We ad
Externí odkaz:
https://doaj.org/article/38eeb434d83440d7b7cd474042626a72
Autor:
Christopher Dravis, Benjamin T. Spike, J. Chuck Harrell, Claire Johns, Christy L. Trejo, E. Michelle Southard-Smith, Charles M. Perou, Geoffrey M. Wahl
Publikováno v:
Cell Reports, Vol 12, Iss 12, Pp 2035-2048 (2015)
To discover mechanisms that mediate plasticity in mammary cells, we characterized signaling networks that are present in the mammary stem cells responsible for fetal and adult mammary development. These analyses identified a signaling axis between FG
Externí odkaz:
https://doaj.org/article/efcb6cbde9454d92a40e80856ddaf3d3
Autor:
Xiaomeng Hou, J Hwang, Charles M. Perou, Bing Ren, Tannishtha Reya, Christy L. Trejo, Zhibo Ma, Christopher Dravis, Sebastian Preissl, Jaslem Herrera-Valdez, Benjamin T. Spike, Roger S. Lasken, Mark Novotny, Geoff Wahl, Elnaz Mirzaei Mehrabad, Berhane M. Hagos, NE Lytle, Ozlen Balcioglu, Olivier Poirion, KT Varley, Chi-Yeh Chung, Cheng Fan, Gidsela Luna, RT Giraddi, Richard E. Heinz
Publikováno v:
Cancer Research. 80:ES10-2
Parallels among embryonic development, stem cells, and cancer have long been recognized. We identified, isolated, and characterized stem cells that first become committed to a mammary fate during embryogenesis; we refer to these cells as fetal mammar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eea19019b08580e51d8685a3f9dde727
https://doi.org/10.1158/1538-7445.sabcs19-es10-2
https://doi.org/10.1158/1538-7445.sabcs19-es10-2
Autor:
Christopher Dravis, Zhibo Ma, Bing Ren, Xiaomeng Hou, Gidsela Luna, Geoffrey M. Wahl, Olivier Poirion, Sebastian Preissl, Chi-Yeh Chung, Rajshekhar R. Giraddi
SummaryIt has only recently become possible to obtain single-cell level resolution of the epigenetic changes that occur during organ development. We reasoned that precision single-cell chromatin accessibility mapping of mammary gland development coul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8e5875cbb0a7a3cb23cb9e180d7e77
https://doi.org/10.1101/624957
https://doi.org/10.1101/624957
Autor:
Chunhui Wang, Wenjun Guo, Yu Liu, Christopher Dravis, John R. Christin, Wei Tang, Maja H. Oktay, Geoffrey M. Wahl, Chi-Yeh Chung
Publikováno v:
Cell reports
SUMMARY Lineage plasticity is important for the development of basal-like breast cancer (BLBC), an aggressive cancer subtype. While BLBC is likely to originate from luminal progenitor cells, it acquires substantial basal cell features and contains a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12d6dc175e68892ac69b31323f649e9
https://doi.org/10.1016/j.celrep.2020.107742
https://doi.org/10.1016/j.celrep.2020.107742
Autor:
Tannishtha Reya, Chi-Yeh Chung, Christy L. Trejo, Geoffrey M. Wahl, Nikki K. Lytle, Christopher Dravis, Gidsela Luna, Jaslem Herrera-Valdez
Intra-tumoral heterogeneity complicates accurate diagnosis, reduces the effectiveness of precision therapeutics, and fuels metastatic dissemination. Discovering the genes and epigenetic mechanisms that produce developmentally plastic cells that engen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b90045f6e455f6e6b14bb30ff4c4ff
https://europepmc.org/articles/PMC6152943/
https://europepmc.org/articles/PMC6152943/
Autor:
Christy L. Trejo, Benjamin T. Spike, Christopher Dravis, Claire Johns, E. Michelle Southard-Smith, Charles M. Perou, J. Chuck Harrell, Geoffrey M. Wahl
Publikováno v:
Cell Reports, Vol 12, Iss 12, Pp 2035-2048 (2015)
SummaryTo discover mechanisms that mediate plasticity in mammary cells, we characterized signaling networks that are present in the mammary stem cells responsible for fetal and adult mammary development. These analyses identified a signaling axis bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0c58fbaa295b9c5c8b8a4182c77a5b
Autor:
Christopher Dravis, Chi-Yeh Chung, Cheng Fan, Rajshekhar R. Giraddi, Mark Novotny, Benjamin T. Spike, Elnaz Mirzaei Mehrabad, Berhane M. Hagos, Ozlen Balcioglu, Roger S. Lasken, Katherine E. Varley, Richard E. Heinz, Christy L. Trejo, Luo Wei Rodewald, Charles M. Perou, Jae Y. Hwang, Geoffrey M. Wahl
Publikováno v:
Cell reports
Cell Reports, Vol 24, Iss 6, Pp 1653-1666.e7 (2018)
Cell Reports, Vol 24, Iss 6, Pp 1653-1666.e7 (2018)
SUMMARY The mammary gland consists of cells with gene expression patterns reflecting their cellular origins, function, and spatiotemporal context. However, knowledge of developmental kinetics and mechanisms of lineage specification is lacking. We add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf69ec6d2a34e3038c5461594a6188d1
https://pubmed.ncbi.nlm.nih.gov/30089273
https://pubmed.ncbi.nlm.nih.gov/30089273