Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christopher Dalldorf"'
Autor:
Irina A. Rodionova, Hyun Gyu Lim, Ye Gao, Dmitry A. Rodionov, Ying Hutchison, Richard Szubin, Christopher Dalldorf, Jonathan Monk, Bernhard O. Palsson
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Hydrogen sulfide (H2S), mainly produced from L-cysteine (Cys), renders bacteria highly resistant to oxidative stress and potentially increases antimicrobial resistance (AMR). CyuR is a Cys-dependent transcription regulator, responsible for t
Externí odkaz:
https://doaj.org/article/b1afa3024ed746f5bdb43eb5a5d15468
Autor:
Christopher Dalldorf, Kevin Rychel, Richard Szubin, Ying Hefner, Arjun Patel, Daniel C. Zielinski, Bernhard O. Palsson
Publikováno v:
mSystems, Vol 9, Iss 7 (2024)
ABSTRACT Fast growth phenotypes are achieved through optimal transcriptomic allocation, in which cells must balance tradeoffs in resource allocation between diverse functions. One such balance between stress readiness and unbridled growth in E. coli
Externí odkaz:
https://doaj.org/article/4144198f5ea442bb88a2dd0454d94938
Autor:
Sourav Chowdhury, Daniel C. Zielinski, Christopher Dalldorf, Joao V. Rodrigues, Bernhard O. Palsson, Eugene I. Shakhnovich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Elucidating intracellular drug targets is a difficult problem. While machine learning analysis of omics data has been a promising approach, going from large-scale trends to specific targets remains a challenge. Here, we develop a hierarchic
Externí odkaz:
https://doaj.org/article/487eb402d5bc4afe9dded197f9fac91e
Autor:
Troy E. Sandberg, Kim S. Wise, Christopher Dalldorf, Richard Szubin, Adam M. Feist, John I. Glass, Bernhard O. Palsson
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107500- (2023)
Summary: The bacterial strain JCVI-syn3.0 stands as the first example of a living organism with a minimized synthetic genome, derived from the Mycoplasma mycoides genome and chemically synthesized in vitro. Here, we report the experimental evolution
Externí odkaz:
https://doaj.org/article/1feada2cbb2c4658a2ca0337974eaee2
Autor:
Akanksha Rajput, Yara Seif, Kumari Sonal Choudhary, Christopher Dalldorf, Saugat Poudel, Jonathan M. Monk, Bernhard O. Palsson
Publikováno v:
mSystems, Vol 6, Iss 1 (2021)
ABSTRACT The two-component system (TCS) helps bacteria sense and respond to environmental stimuli through histidine kinases and response regulators. TCSs are the largest family of multistep signal transduction processes, and they are involved in many
Externí odkaz:
https://doaj.org/article/950ea538f1be458d9d0ab5b3eba61436
Autor:
Irina A. Rodionova, Hyun Gyu Lim, Dmitry A Rodionov, Ying Hutchison, Christopher Dalldorf, Ye Gao, Jonathan Monk, Bernhard O. Palsson
Publikováno v:
bioRxiv
Hydrogen sulfide (H2S), mainly produced from L-cysteine (Cys), renders bacteria highly resistant to oxidative stress. This mitigation of oxidative stress was suggested to be an important survival mechanism to achieve antimicrobial resistance (AMR) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1537cf739b42af6ca3d9a4e42d6b6992
https://europepmc.org/articles/PMC10245726/
https://europepmc.org/articles/PMC10245726/
Autor:
Christopher Dalldorf, Kevin Rychel, Richard Szubin, Ying Hefner, Arjun Patel, Daniel Zielinski, Bernhard Palsson
Fit phenotypes are achieved through optimal transcriptomic allocation. Here, we performed a high-resolution, multi-scale study of the transcriptomic tradeoff between two key fitness phenotypes, stress response (fear) and growth (greed), in Escherichi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dfdd9f1781facd46ce733a23faf44aa
https://doi.org/10.21203/rs.3.rs-2729651/v1
https://doi.org/10.21203/rs.3.rs-2729651/v1
Autor:
Troy E. Sandberg, Kim Wise, Christopher Dalldorf, Richard Szubin, Adam M. Feist, John I. Glass, Bernhard Palsson
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdfb86127edfbb860f2b90464d502f30
https://doi.org/10.2139/ssrn.4147935
https://doi.org/10.2139/ssrn.4147935
Autor:
Josefin Johnsen, Patrick V. Phaneuf, Bernhard O. Palsson, Lei Yang, Se Hyeuk Kim, Sebastian Schulz, Christopher Dalldorf, Emre Özdemir, James T. Yurkovich, Muyao Wu, Richard Szubin, Adam M. Feist, Daniel C. Zielinski
Microbes are being engineered for an increasingly large and diverse set of applications. However, the designing of microbial genomes remains challenging due to the general complexity of biological system. Adaptive Laboratory Evolution (ALE) leverages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::798f0b7cfa614cb1fb7745259b2d853d
https://doi.org/10.1101/2021.07.19.452699
https://doi.org/10.1101/2021.07.19.452699
Autor:
Muyao Wu, Josefin Johnsen, Daniel C. Zielinski, Patrick V. Phaneuf, Sebastian Schulz, Rebecca M. Lennen, Adam M. Feist, Richard Szubin, Bernhard O. Palsson, James T. Yurkovich, Se Hyeuk Kim, Christopher Dalldorf, Emre Özdemir, Lei Yang
Publikováno v:
Phaneuf, P V, Zielinski, D C, Yurkovich, J T, Johnsen, J, Szubin, R, Yang, L, Kim, S H, Schulz, S, Wu, M, Dalldorf, C, Ozdemir, E, Lennen, R M, Palsson, B O & Feist, A M 2021, ' Escherichia coli Data-Driven Strain Design Using Aggregated Adaptive Laboratory Evolution Mutational Data ', ACS Synthetic Biology, vol. 10, no. 12, pp. 3379–3395 . https://doi.org/10.1021/acssynbio.1c00337
Microbes are being engineered for an increasingly large and diverse set of applications. However, the designing of microbial genomes remains challenging due to the general complexity of biological systems. Adaptive Laboratory Evolution (ALE) leverage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb459cb43c19d50489f8275b673ac489
https://orbit.dtu.dk/en/publications/04ef970a-201f-4d43-a05c-70b9bae58c52
https://orbit.dtu.dk/en/publications/04ef970a-201f-4d43-a05c-70b9bae58c52