Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Christopher D. Willey"'
Autor:
Cyntanna C. Hawkins, Amber B. Jones, Emily R. Gordon, Yuvika Harsh, Julia K. Ziebro, Christopher D. Willey, Corinne Griguer, David K. Crossman, Sara J. Cooper, Sasanka Ramanadham, Ninh Doan, Anita B. Hjelmeland
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Sphingolipid metabolism is dysregulated in many cancers, allowing cells to evade apoptosis through increased sphingosine-1-phosphate (S1P) and decreased ceramides. Ceramidases hydrolyze ceramides to sphingosine, which is phosphorylated by sp
Externí odkaz:
https://doaj.org/article/968cfb928d054a14a0cfa5059517fa60
Autor:
George B. H. Green, Alexis N. Cox-Holmes, Olivia Backan, Olivia Valbak, Anna Claire E. Potier, Dongquan Chen, Casey D. Morrow, Christopher D. Willey, Braden C. McFarland
Publikováno v:
Microorganisms, Vol 12, Iss 5, p 1015 (2024)
Along with the standard therapies for glioblastoma, patients are commonly prescribed trimethoprim-sulfamethoxazole (TMP-SMX) and dexamethasone for preventing infections and reducing cerebral edema, respectively. Because the gut microbiota impacts the
Externí odkaz:
https://doaj.org/article/860e3dac2e274328a881d8251a8083df
Autor:
Hongxing Shen, Fengyuan Huang, Xiangmin Zhang, Oluwagbemiga A. Ojo, Yuebin Li, Hoa Quang Trummell, Joshua C. Anderson, John Fiveash, Markus Bredel, Eddy S. Yang, Christopher D. Willey, Zechen Chong, James A. Bonner, Lewis Zhichang Shi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Tumor loss of IFN-γ signalling is a major mechanism of resistance to immune checkpoint blockers. Here the authors report that melanoma cells with knockout of IFNγR1 show constitutive JAK1/2 activation and that the JAK1/2 inhibitor ruxolitinib can o
Externí odkaz:
https://doaj.org/article/d38ce33d0e5a4670b226973e3a573576
Autor:
Kai Chen, Yingnan Si, Jia-Shiung Guan, Zhuoxin Zhou, Seulhee Kim, Taehyun Kim, Liang Shan, Christopher D. Willey, Lufang Zhou, Xiaoguang Liu
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 86 (2023)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/713513ee0b4e4563950e3f3c4a289f7c
Autor:
Mary Smithson, Regina K. Irwin, Gregory Williams, M. Chandler McLeod, E. Karen Choi, Anutosh Ganguly, Ashley Pepple, Clifford S. Cho, Christopher D. Willey, Judith Leopold, Karin M. Hardiman
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 25, Iss , Pp 53-61 (2022)
Treatment of locally advanced rectal cancer includes chemoradiation and surgery, but patient response to treatment is variable. Patients who have a complete response have improved outcomes; therefore, there is a critical need to identify mechanisms o
Externí odkaz:
https://doaj.org/article/e7127184d1b943bc8a3472e24ba7c525
Autor:
Amber B. Jones, Taylor L. Schanel, Mikayla R. Rigsby, Corinne E. Griguer, Braden C. McFarland, Joshua C. Anderson, Christopher D. Willey, Anita B. Hjelmeland
Publikováno v:
Cells, Vol 12, Iss 17, p 2171 (2023)
Treatment for the deadly brain tumor glioblastoma (GBM) has been improved through the non-invasive addition of alternating electric fields, called tumor treating fields (TTFields). Improving both progression-free and overall survival, TTFields are cu
Externí odkaz:
https://doaj.org/article/19c6825befad40668d16c836d7cbcc8d
Autor:
Christian T. Stackhouse, Joshua C. Anderson, Zongliang Yue, Thanh Nguyen, Nicholas J. Eustace, Catherine P. Langford, Jelai Wang, James R. Rowland IV, Chuan Xing, Fady M. Mikhail, Xiangqin Cui, Hasan Alrefai, Ryan E. Bash, Kevin J. Lee, Eddy S. Yang, Anita B. Hjelmeland, C. Ryan Miller, Jake Y. Chen, G. Yancey Gillespie, Christopher D. Willey
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Key molecular regulators of acquired radiation resistance in recurrent glioblastoma (GBM) are largely unknown, with a dearth of accurate preclinical models. To address this, we generated 8 GBM patient-derived xenograft (PDX) models of acquired radiat
Externí odkaz:
https://doaj.org/article/f06e9a8597724e01bcfa17bb759ec86f
Autor:
Raoud Marayati, Laura L. Stafman, Adele P. Williams, Laura V. Bownes, Colin H. Quinn, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Joshua C. Anderson, Christopher D. Willey, Elizabeth A. Beierle
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Despite increasing incidence, treatment for hepatoblastoma has not changed significantly over the past 20 years. Chemotherapeutic strategies continue to rely on cisplatin, as it remains the most active single agent against hepatoblastoma. Ho
Externí odkaz:
https://doaj.org/article/651d99d3286c48f987b6b07498bbc8c8
Autor:
Saeed S. Akhand, Hao Chen, Stephen Connor Purdy, Zian Liu, Joshua C. Anderson, Christopher D. Willey, Michael K. Wendt
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract Trastuzumab-emtansine (T-DM1) is an antibody-drug conjugate (ADC) that efficiently delivers a highly potent microtubule inhibitor to HER2 overexpressing cells. Herein, we utilize HER2 transformed human mammary epithelial cells (HME2) to demo
Externí odkaz:
https://doaj.org/article/c221eeac5a54468f97d9820efc707149
Autor:
Koshi Yamada, Zhi qiang Huang, Milan Raska, Colin Reily, Joshua C. Anderson, Hitoshi Suzuki, Krzysztof Kiryluk, Ali G. Gharavi, Bruce A. Julian, Christopher D. Willey, Jan Novak
Publikováno v:
Kidney Diseases, Vol 6, Iss 3, Pp 168-180 (2020)
Objectives: IgA nephropathy (IgAN) is thought to involve an autoimmune process wherein galactose-deficient IgA1 (Gd-IgA1), recognized as autoantigen by autoantibodies, forms pathogenic immune complexes. Mounting evidence has implicated abnormal activ
Externí odkaz:
https://doaj.org/article/04a78897dbd548889877d84038410961